New data: WATTS’UP® aids in muscle recovery
New data: WATTS’UP® aids in muscle recovery
An exploratory in vitro study is published in collaboration with the Centre for Healthy Eating and Food Innovation at Maastricht University Campus Venlo, the Netherlands. The aim was to investigate the effect of hesperetin, the active ingredient of WATTS’UP®, on muscle regeneration in the presence of oxidative stress. In other words, this study mimicked the conditions of muscle fatigue after strenuous exercise and explored the benefits of hesperetin on myoblast differentiation and therefore muscle recovery.
WATTS’UP®: micronized hesperidin for sports performance
WATTS’UP® is a clinically validated extract from sweet orange, standardized for >90% highly bioavailable hesperidin. In previous proprietary clinical studies, WATTS’UP® has established its beneficial effects on power output and peak power. Many supplement brands in the EU and US have already included this ingredient in their sports nutrition formulas.
The study: Hesperetin but not ellagic acid increases myosin heavy chain expression and cell fusion in C2C12 myoblasts in the presence of oxidative stress (1).
Introduction
Skeletal muscle mass and function are expected to decline with age, resulting in reduced muscle strength. Muscle stem cells (satellite cells) get activated as a result of strenuous physical activity and muscle trauma. They proliferate and migrate as myoblasts to the injured muscle tissue to repair the myofibers. Normal physiological levels of oxidative stress are needed for the proper function of stem cells, however excessive amounts impair their functionality.
To combat this challenge, a diet or supplements rich in polyphenols could reduce oxidative stress and therefore aid in muscle repair. Such polyphenol is for example hesperidin (active form: hesperetin).
Methods:
Muscle cells were cultured with either hesperetin (sweet orange), ellagic acid (pomegranate) or a combination of both in the absence and in the presence of oxidative stress (menadione sodium bisulfate). More details in the full publication: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1377071/full
Results:
Hesperetin treatment in cells exposed to oxidative stress increased myosin heavy chain expression by 35% compared to oxidative stress alone (p<0.01) after 5 days.
Additionally, Treatment with 20 μM hesperetin in C2C12 cells exposed to oxidative stress increased cell fusion compared to oxidative stress alone(p=0.04) as well as control (p=0.02).
Take Home Message:
Hesperetin enhanced myosin heavy chain expression under oxidative stress conditions and promoted cell fusion both with and without oxidative stress exposure. These findings suggest that hesperetin holds potential as a nutritional strategy in supporting fatigued muscles after strenuous exercise. Enhanced myosin heavy chain expression may translate to direct muscle recovery because it is a key protein in muscle fibers responsible for contraction and force generation. Increased myosin heavy chain expression indicates muscle repair and growth, helping restore strength and function after injury or stress.
Hesperitin is the active ingredient in WATTS’UP®, a sweet orange extract clinically validated to support power output and exercise performance. This new data confirms the potential of WATTS’UP® to increase the value of sports nutrition formulas, especially ones targeting muscles recovery.
New Consumer Study: Improvements in Sleep Quality, GI, Psychological and Skin Health
New Consumer Study: Improvements in Sleep Quality, GI, Psychological and Skin health
The latest consumer study with MicrobiomeX®, a natural citrus flavonoid blend, sheds light into its beneficial effects on overall mental wellbeing, gastrointestinal symptoms, skin and sleep quality.
Connecting Gut Health with Whole-Body Wellness
Research increasingly shows that gut microbiota composition impacts various systems in the body through mechanisms like the gut-brain and gut-skin axes. MicrobiomeX® leverages the power of flavonoids to positively modulate the gut microbiome, delivering broad health benefits.
We partnered with iProbio, a leading Slovakian research company specializing in prebiotics, probiotics, and gut health, to delve into the unique relationship between gut microbiota, sleep quality, and overall well-being.
Study Design
Participants (n=57) in the study were asked to take 500 mg of MicrobiomeX® daily and complete self-assessment questionnaires at three key points: baseline, one month, and three months.
Promising Results Already After One Months
After one month of supplementation, participants reported significant (p<0.017) improvements in:
- Enhanced psychological well-being
- Better skin appearance
- Reduced digestive symptoms
- Improved sleep quality
Take Home Message
These results were sustained after three months of supplementation. They reinforce the role of gut health as a cornerstone of overall well-being and highlight MicrobiomeX® as a natural, effective solution for improving skin and sleep quality.
Preliminary results: Brainberry® improves executive function
New preliminary results: Brainberry® significantly improves executive function
New preliminary data sheds light into the effect of Brainberry® on executive function. In our latest clinical study, we assessed executive function and cognitive performance, reflected via the spatial working memory test.
Solabia Nutrition announces preliminary results from a recent clinical study that demonstrate the potential of Brainberry®, our innovative aronia extract ingredient, to significantly improve executive function. This early data adds to the growing body of evidence supporting Brainberry®’s role in cognitive health, specifically targeting areas essential for multitasking and managing daily activities.
Anthocyanins, the key active compounds in Brainberry®, are abundant in aronia berries and have shown promise in supporting neuroprotective effects. Known for their ability to cross the blood-brain barrier, anthocyanins can directly influence brain function and have been studied extensively for their role in potentially improving brain signaling and consequently – executive function.
Study Design and Preliminary Findings
The study, a randomized, double-blind, placebo-controlled, cross-over trial, evaluated the effects of Brainberry® in middle-aged subjects. This demographic is particularly vulnerable to cognitive decline, making Brainberry®’s potential impact especially meaningful.
The results indicate that Brainberry® may support executive function, a crucial component of working memory and multitasking ability.
About Solabia Nutrition
Solabia Nutrition, based in Maastricht, Netherlands, develops and supplies proprietary bioactive formulations to the health and sports nutrition industry. All Solabia Nutrition’s products are clinically tested and from natural origin. The main focus areas are gut microbiome, brain health, energy & vitality and skin health.
Feel free to contact via contact@solabia.com for more information on the possibilities our ingredients have to offer.
New clinical study: Brainberry® improves cognitive performance
New clinical study: Short-term use of Brainberry® improves psychomotor speed and increases BDNF concentration
Press release
New clinical data on the effect of Brainberry® for supporting cognitive function was published in the peer-reviewed European Journal of Nutrition. The results show a significant improvement in psychomotor speed and a significant increase in BDNF after just 1 week supplementation. This publication covers the second published clinical study with positive results from daily Brainberry® intake.
Brainberry®: an active ingredient from Aronia supporting brain fitness.
Brainberry® is a clinically validated extract of Aronia melanocarpa, standardised for cyanidin galactoside. The extract is made from fresh berries of the Nero Eggert variety from the Baltics. Aronia melanocarpa is one of the richest natural sources of a powerful anthocyanin, cyanidin glycosides. These flavonoids are widely recognized for their antioxidant capacity and protective effects on vascular function. Brainberry® was the first aronia melanocarpa extract clinically tested in an earlier double-blind placebo controlled trial. In that first trial (1), Brainberry® intake resulted in significant improvement in focus and psycho-motor control and an increase in cognitive flexibility. The results of this study are also published in a peer reviewed journal (1).
The study: Short‐term Aronia melanocarpa extract supplementation improves cognitive performance: a randomized, double‐blind, placebo‐controlled cross‐over study in healthy young adults
Introduction
This peer-reviewed study was published in the prestigious ”European Journal of Nutrition”, impact factor 5.0. Cognitive capacity is a key factor for learning, memorizing, and thinking. These skills usually peak in young adulthood. Typically, the regular consumption of fruits and specifically berries is often recommended to support these functions. The first clinical trial with Brainberry® was performed in mid-aged or elderly individuals. To fill in this gab, the aim of this research was to determine whether Aronia supplementation could improve the main cognitive domains such as memory and psychomotor speed in young individuals.
Methods
Thirty-five young adults took part in this randomized, double-blind, placebo-controlled cross-over study. They were provided with Brainberry® capsules daily for the duration of 1 (one) week. Cognitive performance was assessed via the Cambridge Neurophysiological Test Automated Battery (CANTAB) (2), the gold standard for precise and objective measures of specific cognitive processes. Additionally, mechanistic markers such as brain-derived neurotrophic factor (BDNF) were measured at baseline and after one week.
Results
All participants demonstrated excellent compliance with the protocol and tolerance of the product (Brainberry®). Psycho-motor control, defined as the time from release of the response button to selection of the target was significantly improved by 4.8% (figure 1).
Figure 1. The difference in reaction time from baseline to 1 week after. *p<0.05 significant difference between groups; 4.5% decrease in the intervention group.
Moreover, serum BDNF concentrations were significantly higher with 5.7% in the intervention group after 1-week Brainberry® intake (p<0.05). BDNF is a protein responsible for neuronal survival and growth, essential for learning and memory (3) and highly relevant for the purpose of this research. Its increase showcases Brainberry®’s potential to support young adults in their daily activities such as learning and working.
Conclusion
This study demonstrates the great potential of Brainberry® in supporting brain fitness for all ages, more specifically psychomotor speed and cognitive performance in young adults. By adding Brainberry® to a nutritional supplement, consumers will benefit from a science-based support for brain functions and neuronal protection.
About Solabia Nutrition
Solabia Nutrition, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition and healthcare industry. We focus on the development of innovative ingredients from plants and microalgae that address active living and healthy ageing. Our goal is to provide the nutrition and healthcare industry with science-based innovations that confer a real health benefit to consumers.
Feel free to contact via contact@solabia.com for more information on the possibilities Brainberry® has to offer. Further information can also be found on: https://solabianutrition.com and https://brainberry.eu
Top 6 ingredients for cognition and eye health
Top 6 ingredients for cognition and eye health
All of our senses allow us to enjoy the world around us and vision is no exception. Cognition is essential to make something meaningful of all senses. As you can imagine, nutrition is crucial in maintaining healthy vision and cognition, since several nutrients are essential for the visual system. In this blog, we embark on a journey to discover these essential nutrients, and, as a bonus, discuss a few compounds that can actually enhance cognition and eye-health!
The connection between cognition and vision
Cognition is a broad term encompassing thinking, learning, memory, and attention; in other words, it refers to all the mental processes that occur in the brain (1). Vision functions as a key information provider to cognition. This relationship between the brain and eyes is crucial since vision can impact performance of cognitive tasks, positively or negatively. Deterioration of eye performance is actually linked to a reduction in cognitive activities like reading and socializing, notably leading to a poor cognitive state (2).
Challenges for a healthy vision
In our modern-day society, numerous factors present challenges to the well-being of both our vision and cognition. One essential challenge is the abundance of time spent behind screens. Digital eye strain is a condition that is attributed to prolonged and extended use of digital screens typically related to symptoms like blurry vision, headaches and dry eyes (3).
According to the American Optometric Association, workers and regular users of digital screen devices are especially at risk. Screen time of two or more hours without interruption, can already lead to aforementioned symptoms (4). More than 60% of the working population in the US report having symptoms related to too much screen time. Moreover, >70% of children and adolescents exceed the two hour screen time as well (5).
Given the extent of the challenges, it becomes imperative to adopt proactive measures to mitigate their effects and safeguard eye health, and cognition by extent. By addressing these factors head-on, we can not only slow down the development of age-related degenerative processes but also actively support the resilience and vitality of our eyes and cognitive functions.
Taking care of our eyes
How should we take care of our eyes? Let’s discuss a couple of easily adoptable measures:
Regular eye check-ups. It’s advisable to have a comprehensive eye examination every two years, regardless of wearing glasses or not (6). Optometrists may prescribe glasses with anti-reflective coatings to protect eyes from harmful blue light emitted by electronic devices.
Adopting eye-friendly behavior. The 20-20-20 rule is a simple and effective measure to reduce eye strain. It encompasses the idea to look at an object at least 20 feet (6 meters) away for 20 seconds, every 20 minutes (7). In order to make this a habit, you can opt to put a timer every 20 minutes when you are at work.
A diet rich in eye-healthy foods. Nutrition is a crucial modifiable factor with the potential for a huge effect on our daily life. There are sources that naturally contain compounds that help in maintaining a healthy vision and cognition. You can think of eggs, fatty fish, certain seeds, nuts and berries.
Eye health supplements. If you are limited by inconvenience or geographical access for food choice, it can be tricky to consume nutrients in recommended quantities through a regular diet. Therefore, adding nutritional supplements is a great additional strategy for reaching the required amount of nutrients in a safe and convenient manner.
The 6 best ingredients for cognition and eye health
When choosing to select supplements for supporting cognition and eye health, you consider a couple of relevant ingredients. Let’s check out the six to keep in mind:
Vitamin A is essential to protect the outer surface of the eye, known as the cornea. It also maintains the function of the retina, which allows us to differentiate colors and shades. Vitamin A can be obtained from yolks, liver and some vegetables like carrots (8). Supplementation is advised if the recommended daily dose cannot be reached via the diet – 900mcg for men and 700mcg for women.
Lutein is a yellow carotenoid pigment, found in the central retina. Its function is to protect against the harmful blue light (9), often emitted by electronic devises. Lutein supplementation may reduce the risk of developing harmful eye conditions. Common sources of lutein include green peas, parsley and kale as well as egg yolks. The daily dose of lutein supplements is between 5-20 mg.
Astaxanthin is a well-known anti-oxidant, often referred to as “the king of the caretonoids”, with health benefits in multiple areas, amongst which eye health. It improves ocular blood flow, enhancing oxygen distribution and waste clearance in the eyes (10). Astaxanthin can be obtained by eating salmon, shrimp and lobster. However, for supplementation purposes, there is a great alternative through microalgae sources, which is a natural and animal-friendly alternative. Supplementation daily dose varies between 4-12 mg (11).
Omega 3 fatty acids are a great strategy for overall health support, including the eyes. Omega-3s could reduce the risk of dry eyes and high eyes pressure (12). Food sources of omega 3 include salmon, herring and tuna. Additionally, supplements derived from fish, krill or microalgae are widely available. The daily dose for supplementation ranges from 500-600mg.
Vitamin E protects the retina from harmful oxidation. It’s crucial for optimal eye health and can be mostly obtained by eating seeds and nuts (13). Daily supplementation dose ranges between 5-12mg (14).
Aronia berry extract. Aronia berries are fruits with a high concentration of anthocyanins, specifically cyanidin-3-0-glycosides (15). These compounds are linked to benefits for cognition, focus, and eye health. BioActor’s proprietary Aronia berry extract, Brainberry®, has been demonstrated to improve focus, concentration and hand-eye coordination at a low daily dose of only 65 mg (16, 17).
