skin health research bonolive

Dermaphenolics Project Collaboration with RUMC

Solabia Nutrition announces the start of the Dermaphenolics Project Collaboration with Radboud University Medical Center

Press Release

Maastricht/Nijmegen, The Netherlands, 13th June 2024

solabia nutrition bonolive skin health

About the Dermaphenolics Project

Solabia Nutrition announces the start of a collaboration around the Dermaphenolics project with Radboud University Medical Center (RUMC), whereby RUMC’s deep understanding of cellular signaling and skin health is combined with Solabia Nutrition’s pipeline of clinical leads.

 

Solabia Nutrition has expertise and experience in the clinical development of innovative active ingredients, extracted from plants (botanicals) with great potential for women’s health, cognitive function, healthy aging and gut-skin axis.

 

RUMC is affiliated with Radboud University in the Netherlands, and is a leading institution in dermatology, both for patient care and mechanistic research in the field of skin biology.

 

The objective of this project is to study the effect of phenolics on in-vitro cultures of skin cells. The project will focus on keratinocyte cellular signaling and skin homeostasis. These phenolic compounds are currently being studied by Solabia Nutrition in exploratory clinical studies for multiple endpoints, including endpoints related to skin physiology.

 

Solabia Nutrition’s head of R&D Yala Stevens takes the lead in this collaboration together with Prof. Ellen van den Bogaard, the head of the Laboratory for Experimental Dermatology.

Yala Stevens, head of R&D at Solabia Nutrition, comments:

“This is a great first step in understanding the impact that our phenolic lead compounds could have on skin cells and skin homeostasis. The Dermophenolics Project will allow us to get mechanistic insights in the area of skin biology and be the basis for further clinical validation.”

About Solabia Nutrition 

Solabia Nutrition, based in Maastricht, Netherlands, develops and supplies proprietary bioactive formulations to the health and sports nutrition industry. All Solabia Nutrition’s products are clinically tested and from natural origin. The main focus areas are gut microbiome, brain health, energy & vitality and skin health.

Feel free to contact via contact@solabia.com for more information on the possibilities our ingredients have to offer.


Solabia Nutrition sponsors the International Probiotic Conference

Solabia Nutrition sponsors the 17th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health 

Maastricht, The Netherlands, 6th June 2024

Prague, here we come! Solabia Nutrition proudly sponsors IPC 2024 for the 3rd year in a row!

solabia nutrition sponsors IPC 2024

Solabia Nutrition Sponsors IPC Gut Health Conference 2024 for Third Consecutive Year

 

Solabia Nutrition announces its continued sponsorship of the IPC Gut Health Conference for the third consecutive year. This scientific conference brings together leading experts, researchers, and business professionals in the field of gut health to share the latest advancements and innovations.

 

As a global leader in nutritional solutions, Solabia Nutrition is dedicated to advancing gut health research and providing cutting-edge ingredients that support microbiome health, gut barrier integrity, SCFA production and IBS symptoms reduction. Our ongoing partnership with the IPC Gut Health Conference underscores our commitment to fostering collaboration and knowledge exchange within the scientific community.

 

This year’s conference promises to be an exceptional platform for discussing the latest research in the area, emerging trends, and practical applications in gut health. Attendees can look forward to insightful presentations and networking opportunities that will drive the future of gut health science.

About Solabia Nutrition 

Solabia Nutrition, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition and healthcare industry. We focus on the development of innovative ingredients from plants and microalgae that address active living and healthy ageing. Our goal is to provide the nutrition and healthcare industry with science-based innovations that confer a real health benefit to consumers.

Feel free to contact via contact@solabia.com for more information on the possibilities our ingredients have to offer.


brainberry new clinical study April 2024

New clinical study: Brainberry® improves cognitive performance

New clinical study: Short-term use of Brainberry® improves psychomotor speed and increases BDNF concentration

Maastricht, The Netherlands, 6th May 2024

Press release

New clinical data on the effect of Brainberry® for supporting cognitive function was published in the peer-reviewed European Journal of Nutrition. The results show a significant improvement in psychomotor speed and a significant increase in BDNF after just 1 week supplementation. This publication covers the second published clinical study with positive results from daily Brainberry® intake.

brainberry improves psychomotor speed and cognitive fundtion

Brainberry®: an active ingredient from Aronia supporting brain fitness.

Brainberry® is a clinically validated extract of Aronia melanocarpa, standardised for cyanidin galactoside. The extract is made from fresh berries of the Nero Eggert variety from the Baltics. Aronia melanocarpa is one of the richest natural sources of a powerful anthocyanin, cyanidin glycosides. These flavonoids are widely recognized for their antioxidant capacity and protective effects on vascular function. Brainberry® was the first aronia melanocarpa extract clinically tested in an earlier double-blind placebo controlled trial. In that first trial (1), Brainberry® intake resulted in significant improvement in focus and psycho-motor control and an increase in cognitive flexibility. The results of this study are also published in a peer reviewed journal (1).

The study: Shortterm Aronia melanocarpa extract supplementation improves cognitive performance: a randomized, doubleblind, placebocontrolled crossover study in healthy young adults

ACCESS THE FULL PUBLICATION

Introduction

This peer-reviewed study was published in the prestigious ”European Journal of Nutrition”, impact factor 5.0. Cognitive capacity is a key factor for learning, memorizing, and thinking. These skills usually peak in young adulthood. Typically, the regular consumption of fruits and specifically berries is often recommended to support these functions. The first clinical trial with Brainberry® was performed in mid-aged or elderly individuals. To fill in this gab, the aim of this research was to determine whether Aronia supplementation could improve the main cognitive domains such as memory and psychomotor speed in young individuals.

 

Methods

Thirty-five young adults took part in this randomized, double-blind, placebo-controlled cross-over study. They were provided with Brainberry® capsules daily for the duration of 1 (one) week. Cognitive performance was assessed via the Cambridge Neurophysiological Test Automated Battery (CANTAB) (2), the gold standard for precise and objective measures of specific cognitive processes. Additionally, mechanistic markers such as brain-derived neurotrophic factor (BDNF) were measured at baseline and after one week.

Results

All participants demonstrated excellent compliance with the protocol and tolerance of the product (Brainberry®). Psycho-motor control, defined as the time from release of the response button to selection of the target was significantly improved by 4.8% (figure 1).

brain berry improves cognitive function after 1 week

Figure 1. The difference in reaction time from baseline to 1 week after. *p<0.05 significant difference between groups; 4.5% decrease in the intervention group.

Moreover, serum BDNF concentrations were significantly higher with 5.7% in the intervention group after 1-week Brainberry® intake (p<0.05). BDNF is a protein responsible for neuronal survival and growth, essential for learning and memory (3) and highly relevant for the purpose of this research. Its increase showcases Brainberry®’s potential to support young adults in their daily activities such as learning and working.

Conclusion

This study demonstrates the great potential of Brainberry® in supporting brain fitness for all ages, more specifically psychomotor speed and cognitive performance in young adults. By adding Brainberry® to a nutritional supplement, consumers will benefit from a science-based support for brain functions and neuronal protection.

ACCESS THE FULL PUBLICATION

About Solabia Nutrition 

Solabia Nutrition, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition and healthcare industry. We focus on the development of innovative ingredients from plants and microalgae that address active living and healthy ageing. Our goal is to provide the nutrition and healthcare industry with science-based innovations that confer a real health benefit to consumers.

Feel free to contact via contact@solabia.com for more information on the possibilities Brainberry® has to offer. Further information can also be found on: https://solabianutrition.com and https://brainberry.eu


bonolive winner nutraingredients award

Bonolive® wins a prestigious Women's Health Award

Bonolive® is the winner in Innovations in Women’s Health NutraIngredients Award!

Maastricht, 17th May 2024

Solabia Nutrition’s revolutionary ingredient, Bonolive®, selected as a winner for NutraIngredients Award in Innovation for Women’s Health!

bonolive wins innovation in women's health

Solabia Nutriton is proud to announce that Bonolive® won the prestigious NutraIngredients Award in Innovation for Women’s Health! Bonolive®’s exceptional contributions to women’s wellness have garnered recognition from industry experts and consumers alike.

Bonolive® is Solabia Nutrition’s patented olive leaf extract, standardized for high levels of oleuropein. It proudly stands as the only oleuropein ingredient patented specifically for women’s health, setting a new standard in innovation. This achievement is well deserved as Bonolive® has undergone several clinical trials in women, particularly during menopause, demonstrating its profound efficacy in supporting their health. Developed by an entirely female-led team, Bonolive® embodies a commitment to women’s wellness like no other.

This achievement underscores Solabia Nutrition’s commitment to advancing nutritional science and empowering individuals to live healthier, more vibrant lives.

We extend our heartfelt gratitude to the NutraIngredients Awards panel for this esteemed recognition!

Feel free to contact us for more information on the possibilities Bonolive® has to offer.

Further information can be found on: www.bonolive.com



    solabia nutrition, formerly known as bioactor

    The BioActor website transitioned into a new Solabia Nutrition website

    Solabia Nutrition, formerly known as BioActor, transitioned to a new website

    Last updated: 10th April, 2024

    Maastricht, 18th March 2024

    We are announcing an important development for our valued customers and partners:

    solabia nutrition, formerly known as BioActor has a new website domain

    The BioActor website transitioned to a brand new Solabia Nutrition website

     

    Joining the Solabia Nutrition family marked a significant milestone in the BioActor journey. As part of this strategic move, we are excited to inform you that the BioActor website is now transformed into a brand new Solabia Nutrition website at www.solabianutrition.com

     

    This transformation represents our commitment to delivering premium nutritional solutions to the health and wellness industry, backed by science. By consolidating our online presence under the Solabia Nutrition brand, we aim to streamline your experience and offer seamless access to our comprehensive portfolio of products and services.

     

    Stay tuned for updates as we work to ensure a smooth transition and provide you with enhanced resources to support your nutritional goals.

     

    If you have any questions, do not hesitate to get in touch!



      bonolive safe FDA GRAS

      FDA GRAS Approval for Bonolive®

      Bonolive® – Solabia-BioActor’s innovative women’s health ingredient, receives FDA GRAS approval

      Maastricht, 6th March 2024

      PRESS RELEASE

      The United States Food and Drug Administration approves Bonolive® as safe for inclusion in supplements, beverages and functional foods. 

      Bonolive safe foods supplements

      Solabia-BioActor received а no objections letter from the U.S. Food and Drug Administration (FDA) regarding their Generally Recognized as Safe (GRAS) application for its women’s health ingredient Bonolive®. The FDA approves Bonolive® for inclusion in Dietary Supplements, Beverages and Functional Foods. 

      For access to the FDA “no objection letter” please follow this link.

      GRAS is a designation created by the FDA under the Federal Food, Drug and Cosmetic Act. It is a testament to the safety of a food ingredient or additive based on adequate evidence. Bonolive® had already shown a clean safety profile in published tox studies and a GRAS panel had concluded that Bonolive® should be considered GRAS.

      Bonolive® is an oestrogen-free, patented ingredient, standardised for high levels of oleuropein. This all-natural ingredient is clinically validated in post-menopausal women to support women’s health during post-menopause. Human intervention studies showed that Bonolive® plays a key role in:

      • stimulating bone-building cells (osteoblasts) and stabilising bone mineral density
      • improving blood lipid profile
      • reducing joint pain and improving mobility.

      A recent consumer study in menopausal women also showed that Bonolive® helps alleviating menopause related symptoms related to mood and skin appearance. Interestingly, a pharmacokinetics study showed that Bonolive® has an enhanced bioavailability in post-menopausal women.

      Bonolive® targets women in peri- and post menopause that are looking for a safe, natural and oestrogen-free solution to the challenges of menopause. It is a true innovation as the only clinically evaluated olive leaf extract for women’s health. This ingredient is now also available in a convenient RTD format for everyday easy intake.

      Feel free to contact us via info@bioactor.com for more information on the possibilities Bonolive® has to offer.

      Further information can be found on: www.bonolive.com

       

      About Solabia Nutrition

      Solabia Nutrition, a part of Solabia Group, is a product development company that has developed a range of proprietary bioactive formulations with clinical studies. Based in Maastricht, the Netherlands, the company focuses on the development of innovative bioactives that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.


      New Approved Health Claim for Watts'Up®

      WATTS’UP® receives an additional approved health claim from Health Canada

      Maastricht, 14th February 2024

      PRESS RELEASE

      Health Canada has issued a new Product Licence for WATTS’UP® and has approved the use of an additional health claim: “Helps to improve average power output during high intensity exercise in moderately trained individuals.

      power strength wattsup bioactor solabia

      WATTS’UP®, a customized flavonoid extract from sweet orange, has been tested in 2 double-blind placebo-controlled studies. The latest study was conducted in moderately trained men and women and showed a significant improvement in exercise performance with a significant increase in peak force and average 30 seconds power output.

      Health Canada has issued a new Product Licence for WATTS’UP® with an enlarged scope. Pursuant to this Product Licence, WATTS’UP® is recommended to be used as “Athletic support” or “Workout/Exercise supplement.”

      The following specific claims have been allowed by Health Canada: “Helps to improve average power output during high intensity exercise in moderately trained individuals” ; “Helps improve physical performance during exercise in trained male athletes”; and “Provides antioxidants that help cells to fight against the oxidative effect of free radicals and that helps protect cells and reduce oxidative damage and cell damage caused by free radicals”

      The Journal of the International Scoiety of Sports Nutrition has published the results of the latest clinical study with WATTS’UP®. WATTS’UP® is a patent-protected citrus extract with enhanced bioavailability. It was tested in moderately trained athletes (both men and women) and showed a significant increase in power output during the Wingate anaerobic exercise test.

      WATTS’UP® can be found on the market in multiple products in the USA, Europe, and Asia. It can be applied in various finished dosage forms, including powders, effervescent tablets, capsules, RTD sachets and beverages.

      Feel free to contact us via info@bioactor.com for more information on the possibilities WATTS’UP® has to offer.

      Further information can be found on: www.wattsup.eu

       

      About Solabia – BioActor

      BioActor, a Solabia Nutrition company, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive formulations with clinical studies. The company focuses on the development of innovative bioactives that address healthy living and ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

      For further information, see www.bioactor.com


      Solabia BioACtor Quadram Institute

      BioActor & Quadram Institute announce collaboration

      Solabia-BioActor announces the start of a collaboration with The Quadram Institute to assess the bioavailability and kinetics of Brainberry®

      Maastricht/Norwich, 29th November  2023

      Solabia-BioActor announces the start of a collaboration with The Quadram Institute to assess the bioavailability and kinetics of Brainberry®, Solabia-BioActor’s proprietary Aronia melanocarpa extract.

      Solabia BioActor Quadram Institute

      Solabia-BioActor has expertise and experience in developing innovative active ingredients, extracted from plants (botanicals) with great potential to support human health in terms of cognitive support, healthy aging and gut health enhancement.

       

      The Quadram Institute is a premier research organization, based at the Norwich Research Park in the United Kingdom. It is home to researchers and clinicians that work together to develop world-class health, microbiome and food science. 

       

      Solabia-BioActor’s Senior Scientist Sanne Ahles takes the lead on this collaboration together with Dr. Paul Kroon, a principal investigator at The Quadram Institute. Dr. Kroon is the leader of the Polyphenols and Health Group and his research focuses on understanding the mechanisms by which dietary polyphenols are absorbed and exert health benefits.

       

      The objective of this project is to study the bioavailability and kinetics of Brainberry®, a proprietary aronia melanocarpa extract, in human volunteers. BioActor will carry-out the human intervention study and the Quadram Institute will identify and quantify a broad range of metabolites in a variety of samples obtained in the study.

      Sanne Ahles, Senior Scientist at Solabia-BioActor comments:

      “The bioavailability of Brainberry® has not been researched until this point. This collaboration with the Quadram Institute will allow us to broaden our knowledge regarding the anthocyanin metabolism and shed light on any possible differences between its steady-state bioavailability in young and older adults.”

      About Solabia-BioActor

      Solabia-BioActor, based in Maastricht, Netherlands, is a product development company that develops and supplies proprietary bioactive formulations to the health and sports nutrition industry. All Solabia-BioActor’s products are clinically tested, doping-free and from natural origin. The main focus areas are: gut microbiome, brain health, energy & vitality and skin health.


      Brainberry®: Winner of Ingredient Idol 2023

      Brainberry® is the Winner of Ingredient Idol 2023, Nootropics 

      Maastricht, The Netherlands, 2nd November  2023

      We are happy to announce that Brainberry® won the Ingredient Idol 2023 award in the Nootropics Category! The contest was organized by Informa Markets and held at SupplySide West on October 26, 2023 in Las Vegas.

      Ingredient Idol winner

      Out of all ingredients that were submitted for the competition in the Nootropics category, Brainberry® was selected as one of the three finalists that was invited to give a 3-min elevator pitch at the SupplySide West show in Las Vegas. Brainberry® was voted as Winner by the respected jury because of its unique clinically validated benefits on psychomotor control, better focus and mental flexibility.

      Judges were three experienced professionals in the field of health and nutrition:

      • David Foreman, also known as “The Herbal Pharmacist” is an established author, and currently on the  editorial advisory board for Nutritional Outlook and on the content advisory board for Vitafoods Europe, Vitafoods Asia and Vitafoods Insights.

       

      • Douglas Lynch, CEO of MarketWell Nutrition Inc., has three decades of experience in the clinical nutrition and wellness industries. He has an award-winning product background in sales and marketing of dietary supplements, medical foods, functional foods, cosmetics, animal nutrition, and proprietary actives.

       

      • Diana Morgan, VP of global regulatory and government affairs for Nutrabolt, makers of the famous C4 Energy, is the founder of What’s Up with Supps. She has numerous years of experience in the natural products industry, having worked for reputable brands in the US nutritional supplement industry.

      We are thankful to the jury and all visitors at SupplySide West for voting Brainberry® as the winner in the Nootropics category of Ingredient Idol 2023. Brainberry® was recognized for its advantages such as the low daily dose of 65mg, clinically backed benefits for improving focus and eye-hand coordination, and convenience of formulating in different product formats.

      We strongly believe in the importance of clinical research backing up all our ingredients in order to offer true innovation in the health ingredients market. Brainberry® is an extract from Aronia Melanocarpa, standardized for Cyanadin-3-O-glycosides (>25%) and, specifically cyanidin-3-O-galactoside (>15%). It is able to cross the blood-brain barrier and improve neuronal signaling and synaptic plasticity. It is positioned for brain and cognitive support suitable for students, workers, gamers and athletes.

      Consumer studies with acute and 7-days intake of 65mg Brainberry® among gamers and professional basketball players demonstrate improved eye-hand coordination, focus and reaction time, without negative impact on sleep or anxiety in self-reported questionnaires.

       

      To learn more about Brainberry®, visit www.brainberry.eu, to explore other clinically validated ingredients by Solabia-BioActor, click here.


      gut health or butyrate or short chain fatty acids

      New clinical study: MicrobiomeX® improves microbiota composition and SCFA production

      New clinical study: MicrobiomeX® improves microbiota composition and SCFA production

      Maastricht, The Netherlands, 29th September  2023

      Press release

      New clinical and pre-clinical data from a study with MicrobiomeX® have been published in a peer-reviewed journal. It is a randomised, double-blind, placebo-controlled parallel study performed by scientists of Maastricht University, the department of Gastro-enterology of Maastricht University Medical Center and BioActor. It shows the potential of MicrobiomeX® to improve short-chain fatty acid (SCFA) profiles in the intestine. After 12 weeks of daily supplementation, there was a significant shift in the SCFA profile (p=0.022) towards butyrate. In addition, a reduction in faecal calprotectin levels was observed, a marker of gut inflammation. Interestingly, a new in-vitro study in the TIM2 model, where faecal samples from volunteers were tested, also showed a strong increase in butyrate production. These new clinical and pre-clinical results highlight MicrobiomeX®’s potential to support intestinal microbiota of subjects with features of metabolic syndrome.

      gut health or butyrate or short chain fatty acids

      MicrobiomeX®: an an active ingredient supporting the gut microbiome, developed by BioActor

      MicrobiomeX® is a clinically validated blend of Citrus sinensis (sweet orange) and Citrus paradisi (grapefruit) extracts. These fruits are naturally rich in flavonoids, known for their anti-inflammatory and antiviral properties (1, 2). MicrobiomeX® already showed promising potential to reduce markers of gut inflammation and increase SCFAs in previous in-vitro and ex-vivo studies conducted with this ingredient (3, 4). Supplement brands all over the world have adopted MicrobiomeX® in their formulations, typically positioned for improving gut microbiome balance and immune system regulation.

      The study: Citrus Extract High in Flavonoids Beneficially Alters Intestinal Metabolic Responses in Subjects with Features of Metabolic Syndrome

       

      Introduction

      This study (5) was published in the international journal “Foods”. The western diet and lifestyle may be the leading causes for the development of various metabolic disorders. An overlooked factor is the gut microbiota composition, which should be considered as a factor determining health status. A healthy gut is related to mental wellbeing and strong immunity. This study aimed to evaluate the benefits of MicrobiomeX® supplementation on the intestinal microbiome of subjects with metabolic disorder traits.

      Methods

      Fifty adult subjects with features of metabolic syndrome took part in the study. They ingested 500mg MicrobiomeX® or placebo daily for 12 weeks. Additionally, seven volunteers provided faecal samples that were introduced into a TIM-2 system for further analysis. The TIM-2 is a computer-controlled model in an anaerobic environment that replicates the appropriate conditions for microbial growth in the human colon and is able to measure microbiota composition and SCFA production.

      Results

      A significant shift in the SCFA profile towards more butyrate (p=0.022) was observed in the MicrobiomeX® group after the 12-week supplementation period. An increase in SCFA production was also found in the TIM-2 model, that was mainly due to an increased production of butyrate, acetate and valerate. Additionally, in the MicrobiomeX® group, a trend in calprotectin reduction was observed, which is a marker of gut inflammation. Both in vivo and in vitro data confirm the benefits of MicrobiomeX on gut health, specifically the increased butyrate production and improved SCFA profile. These findings are in line with previous in vitro results and show that MicrobiomeX® can beneficially modulate the gut microbiome.

      Conclusion

      This study demonstrates the great potential of MicrobiomeX® in playing a role in gut health modulation. This is indicated by the significant increase in SCFAs, mainly butyrate, and a reduction in calprotectin, as found in the present study. By adding MicrobiomeX® to your supplement, you can offer customers a science-based support for gut health. It is an alternative to common prebiotics and an ideal partner for synbiotic formulation targeting gut health and immunity.

      Click here to read the complete publication

      About BioActor

      BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

      Feel free to contact via info@bioactor.com for more information on the possibilities MicrobiomeXl® has to offer. Further information can also be found on: https://solabianutrition.com/products/microbiomex/ and https://microbiomex.com/