New data: WATTS’UP® aids in muscle recovery

Maastricht, 11th December 2024

An exploratory in vitro study is published in collaboration with the Centre for Healthy Eating and Food Innovation at Maastricht University Campus Venlo, the Netherlands. The aim was to investigate the effect of hesperetin, the active ingredient of WATTS’UP®, on muscle regeneration in the presence of oxidative stress. In other words, this study mimicked the conditions of muscle fatigue after strenuous exercise and explored the benefits of hesperetin on myoblast differentiation and therefore muscle recovery.

WATTS’UP®: micronized hesperidin for sports performance

WATTS’UP® is a clinically validated extract from sweet orange, standardized for >90% highly bioavailable hesperidin. In previous proprietary clinical studies, WATTS’UP® has established its beneficial effects on power output and peak power. Many supplement brands in the EU and US have already included this ingredient in their sports nutrition formulas.

The study: Hesperetin but not ellagic acid increases myosin heavy chain expression and cell fusion in C2C12 myoblasts in the presence of oxidative stress (1).

Introduction

Skeletal muscle mass and function are expected to decline with age, resulting in reduced muscle strength. Muscle stem cells (satellite cells) get activated as a result of strenuous physical activity and muscle trauma. They proliferate and migrate as myoblasts to the injured muscle tissue to repair the myofibers. Normal physiological levels of oxidative stress are needed for the proper function of stem cells, however excessive amounts impair their functionality.

To combat this challenge, a diet or supplements rich in polyphenols could reduce oxidative stress and therefore aid in muscle repair. Such polyphenol is for example hesperidin (active form: hesperetin).

Methods:

Muscle cells were cultured with either hesperetin (sweet orange), ellagic acid (pomegranate) or a combination of both in the absence and in the presence of oxidative stress (menadione sodium bisulfate). More details in the full publication: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1377071/full

Results:

Hesperetin treatment in cells exposed to oxidative stress increased myosin heavy chain expression by 35% compared to oxidative stress alone (p<0.01) after 5 days.

Additionally, Treatment with 20 μM hesperetin in C2C12 cells exposed to oxidative stress increased cell fusion compared to oxidative stress alone(p=0.04) as well as control (p=0.02).

Take Home Message:

Hesperetin enhanced myosin heavy chain expression under oxidative stress conditions and promoted cell fusion both with and without oxidative stress exposure. These findings suggest that hesperetin holds potential as a nutritional strategy in supporting fatigued muscles after strenuous exercise. Enhanced myosin heavy chain expression may translate to direct muscle recovery because it is a key protein in muscle fibers responsible for contraction and force generation. Increased myosin heavy chain expression indicates muscle repair and growth, helping restore strength and function after injury or stress.

Hesperitin is the active ingredient in WATTS’UP®, a sweet orange extract clinically validated to support power output and exercise performance. This new data confirms the potential of WATTS’UP® to increase the value of sports nutrition formulas, especially ones targeting muscles recovery.

New Consumer Study: Improvements in Sleep Quality, GI, Psychological and Skin health

Maastricht, 5th December 2024

The latest consumer study with MicrobiomeX®, a natural citrus flavonoid blend, sheds light into its beneficial effects on overall mental wellbeing, gastrointestinal symptoms, skin and sleep quality.

Connecting Gut Health with Whole-Body Wellness

Research increasingly shows that gut microbiota composition impacts various systems in the body through mechanisms like the gut-brain and gut-skin axes. MicrobiomeX® leverages the power of flavonoids to positively modulate the gut microbiome, delivering broad health benefits.

We partnered with iProbio, a leading Slovakian research company specializing in prebiotics, probiotics, and gut health, to delve into the unique relationship between gut microbiota, sleep quality, and overall well-being.

Study Design

Participants (n=57) in the study were asked to take 500 mg of MicrobiomeX® daily and complete self-assessment questionnaires at three key points: baseline, one month, and three months.

Promising Results Already After One Months

After one month of supplementation, participants reported significant (p<0.017) improvements in:

• Enhanced psychological well-being
• Better skin appearance
• Reduced digestive symptoms
• Improved sleep quality

Take Home Message

These results were sustained after three months of supplementation. They reinforce the role of gut health as a cornerstone of overall well-being and highlight MicrobiomeX® as a natural, effective solution for improving skin and sleep quality.

New preliminary results: Brainberry® significantly improves executive function

Maastricht, 25th October 2024

New preliminary data sheds light into the effect of Brainberry® on executive function. In our latest clinical study, we assessed executive function and cognitive performance, reflected via the spatial working memory test.

Solabia Nutrition announces preliminary results from a recent clinical study that demonstrate the potential of Brainberry®, our innovative aronia extract ingredient, to significantly improve executive function. This early data adds to the growing body of evidence supporting Brainberry®’s role in cognitive health, specifically targeting areas essential for multitasking and managing daily activities.

Anthocyanins, the key active compounds in Brainberry®, are abundant in aronia berries and have shown promise in supporting neuroprotective effects. Known for their ability to cross the blood-brain barrier, anthocyanins can directly influence brain function and have been studied extensively for their role in potentially improving brain signaling and consequently – executive function.

Study Design and Preliminary Findings

The study, a randomized, double-blind, placebo-controlled, cross-over trial, evaluated the effects of Brainberry® in middle-aged subjects. This demographic is particularly vulnerable to cognitive decline, making Brainberry®’s potential impact especially meaningful.

The results indicate that Brainberry® may support executive function, a crucial component of working memory and multitasking ability.

Access more data on this study here