antioxidants polyphenols and astaxanthin

What are antioxidants?

What are antioxidants?

Maastricht, 19th July, 2024

Everybody has heard of antioxidants as they are commonly discussed in health, bringing several benefits. However, what exactly are antioxidants, and why do they matter? This blog will explain the notion of antioxidants, how they operate and what is their relevance in maintaining good health.

antioxidants polyphenols and astaxanthin

Understanding antioxidants

What are Antioxidants?

Antioxidants are molecules that neutralize free radicals, which are unstable substances that can harm cells. Free radicals are naturally produced by numerous body processes, but they may also be caused by external influences such as pollution and smoking. In cases of strenuous exercise or other stressful for the body circumstances, free radicals could over accumulate and produce oxidative stress, which harms cells and contributes to chronic diseases (1). Fortunatelly, antioxidants can neutralize the free radicals and restore cellular balance.

How do Antioxidants work?

Antioxidants neutralize free radicals by donating an electron to stabilize these reactive molecules, thus preventing them from causing cellular damage. This process is essential in protecting the body from oxidative stress, which is associated with aging and various long-term conditions (2).


Sources of Antioxidants

Natural Sources (3):

  • Fruits and Vegetables: Rich in vitamins C and E, and beta-carotene, found in foods like berries, carrots, and spinach.
  • Nuts and Seeds: High in vitamin E and selenium.

Dietary Supplements:

  • Astaxanthin is the most potent antioxidant from natural origin. It is extracted from H. Pluvialis microalgae. Daily supplementation requires a conveninet dose, bringing health advantages in terms of cellular health, longevity and healthy aging.
  • Polyphenols are another strong source of antioxidants that is much more sustainable and safe than synthetic antioxidants. They can be supplemented as extracts from citrus fruits in an easy to get, single daily dose format.

Health benefits of Antioxidants


  • Longevity support

Antioxidants can help prevent the oxidation of cholesterol, reducing the risk of cardiovascular problems and protecting cells from DNA damage (4).

  • Anti-Aging Properties

Oxidative stress significantly contributes to the aging process. Antioxidants can help mitigate this, promoting healthier, younger-looking skin (5).


Antioxidants help to protect the body against oxidative stress and free radical damage, linked to a number of chronic conditions and the aging process. Consuming antioxidant-rich foods and taking quality supplements can help you maintain cellular health and longevity. As research into antioxidants advances, their importance in our daily lives becomes more apparent, underlining their crucial role in maintaining long-term health.

actiful - ingredient for mitochondria

Ingredients to support mitochondrial health

Ingredients to support mitochondrial health

Last updated: July 12th, 2024

August 8th, 2023

Discover the influence of nutrients on your mitochondrial health. Dive into our blog to learn how magnesium, hesperidin, vitamin C, omega-3s, and more can enhance your mitochondrial health and boost your overall vitality.

actiful - ingredient for mitochondria

Nutrients to support mitochondrial health

Maintaining the optimal performance of our mitochondria is pivotal for our overall well-being. These microscopic organelles act as cellular powerhouses, generating the energy necessary for our optimal cell function.

Beyond energy production, they also regulate metabolic processes and uphold a delicate balance of nutrients within our cells

Dysfunctional mitochondria could result in symptoms like fatigue and muscle weakness. In more serious instances, they could lead to long-term health conditions.

Consequently, prioritizing the health of our mitochondria is not only essential for general vitality but also plays a preventive role against potential illnesses.

Within this article, we will take a look at specific nutrients that actively contribute to the maintenance and augmentation of mitochondrial health.

Magnesium and mitochondrial vitality

Magnesium plays a vital role in ensuring the well-being of our mitochondria. It serves as a crucial facilitator for enzymes responsible for energy production, while also exhibiting antioxidant properties.

The antioxidative function of magnesium is particularly significant, shielding mitochondria from potential risks induced by harmful molecules. Additionally, magnesium regulates calcium levels within mitochondria, a pivotal function in avoiding potential malfunctioning (1).

Sustaining an appropriate intake of magnesium is essential to uphold the health of mitochondria. Incorporating magnesium-rich foods into our diet, such as nuts, seeds, whole grains, and leafy green vegetables, provide a natural source of this essential mineral.

Hesperidin: a citrus boost for mitochondria

Hesperidin, a natural compound present in citrus fruits like oranges, lemons, and grapefruits, plays a big role in maintaining mitochondrial health.

By boosting the expression of genes linked to energy production, hesperidin enhances mitochondrial functionality. This augmentation translates to increased energy production within the mitochondria, resulting in elevated energy levels and reduced fatigue (2).

Moreover, hesperidin has an anti-inflammatory effects. As inflammation can contribute to mitochondrial disturbances, mitigating this challenge becomes paramount mitochondrial well-being.

Vitamin C to boost mitochondrial health

Vitamin C holds a crucial role in maintaining the well-being of our mitochondria. Serving as one of the body’s most potent antioxidants, vitamin C offers safeguarding powers against detrimental molecules known as free radicals, shielding our mitochondria from harm (3).

Free radicals possess the capacity to impair mitochondria, diminishing their capacity to generate energy. However, vitamin C effectively counters these radicals, preventing the damaging effects.

Therefore, ensuring your diet includes a good dose of vitamin C becomes a noteworthy strategy to keep healthy mitochondria.

Omega-3s: helpful for energy

Omega-3 fatty acids are a type of healthy fat found in foods like fatty fish, nuts, and seeds. They play a crucial role in promoting the health of mitochondria.

Omega-3s could boost mitochondrial function: they help these powerhouses generate more energy from the same amount of nutrients, which leads to less fatigue and more energy (4). Omega-3s also shield mitochondria from damage caused by harmful molecules.

Including foods rich in omega-3s in our diet is a smart move to support your mitochondria, boost energy production, and keep inflammation in check.

Astaxanthin: the key to alleviate mitochondrial ROS

Astaxanthin aids in the neutralization of oxidative stress within mitochondria, thereby contributing to overall mitochondrial health and proper mitochondrial functioning.

Astaxanthin is a very strong antioxidant that can be derived from the microalgae H. Pluvialis. Due to its lipophilicity, astaxanthin is able to cross cell membranes, and thereby reach the mitochondria. Due to its antioxidant activity within the mitochondria, it is able to scavenge Reactive Oxygen Species (ROS) and other free radical types, and thus decrease oxidative stress. It also exerts anti-inflammatory effects. Hereby, proper functioning of the mitochondria, including mitochondrial respiration and energy production, is supported (5).

Next to the microalgae H. Pluvialis, astaxanthin can also be found within seafoods such as salmon, crab and shrimp.


In summary, looking after the health of mitochondria is vital for general well-being. A range of nutrients, such as hesperidin, magnesium, astaxanthin, omega-3 fatty acids, and vitamin C, play key roles in supporting mitochondrial function, helping to diminish oxidative stress and inflammation.

By incorporating these essential nutrients in the diet, we can effectively boost our mitochondrial health and ensure optimal energy production.

tips for healthy aging

4 Tips for Healthy Aging

4 Tips for Healthy Aging

Maastricht, 5th July, 2024

People worldwide are aiming to live longer and the key to enjoying those extra years is ensuring quality aging. It’s not just about getting older, it’s about getting older in good health. This is a global issue that affects everyone. How to achieve it?

tips for healthy aging

What is aging?


Aging itself isn’t a disease, but it does make us more vulnerable. Good health in old age means maintaining independence, which involves two main aspects: mobility, which can be driving a car or simply going to the toilet; and cognitive health – your ability to think, learn, and remember. There is a link between them as being sedentary can negatively impact your cognitive health (1). So, how to limit the loss of mobility and maintain cognitive health?

Tips for Healthy Aging


1.Take Care of Your Mental Health: As people age, they may experience certain life changes, such as retirement, which is a significant risk factor for mental health issues like depression (2, 3). Depression, in turn, is an established risk factor for functional mobility impairment (4). Additionally, stopping work may often result in memory loss and experiencing reduced social interaction, both crucial for cognitive health. Social interaction is extremely beneficial for memory (5) and should be encouraged especially after retirement.


2.Stay Physically Active: Regular physical activity is crucial for successful aging as it preserves muscle performance, promotes mobility, and reduces the risk of falls, thereby significantly boosting physical well-being (6). Physical exercises like yoga or walking also improve psychological well-being (including depression) by reducing muscle tension (7). Moreover, physical activity supports brain health by promoting brain maintenancе (8). It induces biological and structural changes in the brain (9), increases blood flow and oxygen delivery to your brain, which helps with memory and learning by benefiting the hippocampus, a key memory structure (7). This is essential since aging is associated with memory decline (10). To prevent it, engage yourself in activities like jogging, running, cycling, or swimming.


3.Take Care of Your Cognitive Health: Some people may possess or develop a cognitive reserve that helps them resist cognitive aging and reduce the impact of potential brain damage (11). This means their brain can function well even when affected by similar levels of deterioration as others. Key factors that improve cognitive reserve include cognitive stimulation and lifelong learning (12). To increase focus and protect your memory, use it regularly. Try navigating without maps, memorize your relatives’ phone numbers, read or learn a new language.


4.Make Smart Food Choices: Consuming flavonoid-rich foods, such as berries or citrus fruits throughout life may help limit or even reverse age-related memory and cognitive decline. Polyphenols, found in these foods, improve synaptic transmission, increase synaptic plasticity, and enhance neurogenesis. These compounds not only provide various other health benefits that collectively support memory (10, 13), but also may enhance muscle health (14), which is important for maintaining mobility. Additionally, there is an inverse relationship between the intake of polyphenols and depressive symptoms—the more you consume, the less likely you are to experience depression (15), supporting both mental well-being and cognitive health.




Healthy aging is about maintaining physical and cognitive health. By staying active, caring for mental and cognitive well-being, and making smart food choices, you can enjoy your later years with greater independence and vitality. Aging well is not just about adding years to life but adding life to years.

astaxanthin for cellular health

How to promote longevity via cellular health?

How to promote longevity via cellular health?

Maastricht, 21st June, 2024

Longevity refers to living a longer and healthier life. While aging is a natural process, it is possible to minimize the physical and cognitive decline that comes with it and reduce the risk of certain diseases. The question is: how to achieve this?

astaxanthin for cellular health

The body is a complex network of cells and tissues that communicate with each other to perform all its functions. This article will how longevity can be promoted at three levels:

  • Cellular health, notably by combatting oxidative stress and making the mitochondria work better
  • Organ health, notably by preventing arterial stiffness and by gut microbiota
  • Whole body health by enhancing mobility, brain fitness and mental wellness.


What is oxidative stress?

Oxidative stress occurs when there is a physiological imbalance between the production of reactive oxygen species (ROS) and the cell’s ability to neutralize them.

Mitochondria, the organelles that produce energy for cellular functions, are also a production site of ROS. That is because cellular respiration, the metabolic pathway in mitochondria that produces energy, also generates ROS (1).

ROS are oxidants that can cause damage to cellular components like proteins and DNA, leading to the formation of toxic compounds. One such compound is 4-hydroxy-2-nonenal (4-HNE), which amplifies oxidative stress by damaging cell membranes (2).

Although our bodies have endogenous defense systems to combat oxidative stress, their efficiency decreases with age. Therefore, it is crucial to support mitochondria for longevity and overall cell health by including antioxidant-rich foods in our diet.

For instance, vitamin C contributes to mitochondrial well-being (3). Therefore, consuming vitamin C-rich foods, such as citrus fruits, help maintain mitochondrial health and cellular homeostasis. Another example is Haematococcus pluvialis, a type of microalga, naturally produces one of the strongest antioxidants: astaxanthin.  Astaxanthin protects cell membrane by scavenging ROS in both the inner and outer layers (4).

quality of life and longevity

What is the effect of aging on tissue health?

The tissues in our body are composed of groups of cells that share similar features and functions. Tissues are prone to deterioration with age. For example, aging is a major risk factor for vascular dysfunction and the development of vascular diseases.

Elastin and collagen are proteins that provide mechanical properties to blood vessels, with elastin contributing to their elasticity and collagen to their rigidity. As blood vessels age, they tend to become stiffer due to a decrease in elastin fibers and an increase in collagen fibrils.

A metabolic reaction that can amplify vessel stiffness is glycation. This reaction occurs between sugars and amino groups from proteins, lipids or nucleic acids, resulting in the formation of advanced glycation end products (AGEs). While the formation of AGEs is a normal part of metabolism, high levels of AGEs in tissues and circulation can be harmful (5).


How to prevent cognitive and physical decline with age?

Changes at cellular and tissue levels are perceptible in the physical and mental state of the body. As we age, the loss of muscle mass leads to general mobility issues and reduced strength. By the age of 80, 30% of muscle mass is lost, and this percentage can be higher if physical inactivity is combined with poor nutrition (6).  This decline in muscle capacity is partly due to a decrease in both the number and functionality of mitochondria, resulting in less energy being produced for muscle tissues.

Additionally, aging makes problem-solving and memorization more challenging. Brain-derived neurotrophic factor (BDNF) is a protein crucial for neuronal cell survival and plasticity. It plays a key role in the generation of neurons in the central nervous system.

A balanced diet rich in red fruits is beneficial for cognitive health because of their high anthocyanins content, molecules known for their positive and protective effects on the nervous tissues (7).  Studies have shown that a one-week supplementation of 180mg anthocyanin per day increased BDNF levels in healthy young adults (8).


Therefore, to promote longevity, it is important to include antioxidant-rich foods, stay mentally active, consume enough protein to support muscle mass, stay well-hydrated, and get sufficient sleep. Moreover, specific supplementation with nutrients that stimulate mitochondrial efficiency, protect arteries, promote brain fitness, mobility and mental wellness will further boost cellular health and overall longevity.

Actiful Energy

Top 6 Reasons to Include Actiful® in Your Energy Supplement

Top 6 Reasons to Include Actiful® in Your Energy Supplement

Last updated: June 14th, 2024

November 1st, 2021

As energy-boosting dietary supplements are gaining popularity among consumers, the need for clinically proven health ingredients is growing accordingly. If you are a formulator looking to craft an effective product targeting energy & vitality, you may be overwhelmed by the many ingredients available out there. Can’t make your mind up? In this article, we explore the top 6 reasons to include Actiful® in your product.

Actiful Energy

The growing interest in energy-boosting supplements.

In today’s hectic world, more than ever, people suffer from tiredness and lack of energy. Many consumers indeed tackle physical and mental stress with the help of dietary energy-boosting supplements, which help them avoid fatigue, do more sports and be more socially active.

The interest in nutritional solutions for an extra energy kick is increasingly gaining popularity. In fact, according to the recent CRN consumer survey on dietary supplements, improving energy levels is among the top 5 reasons for consuming such products (28%, a 7% increase yearly), showing how people rely on supplements to get through the day.

What is Actiful®?

Actiful® is a patent-protected orange and pomegranate complex, specifically designed to enhance energy and vitality, affecting short-term and long-term energy systems and improving mood.

This all-natural ingredient is standardized for highly bioavailable hesperidin, an important polyphenol found in sweet oranges (Citrus Sinensis). Hesperidin-containing foods are part of the type of foods that are good to support your daily energy.

Solabia Nutrition, previously known as BioActor, developed Actiful® and, together with Maastricht University, researched the ingredient and confirmed its health benefits in multiple randomized, double-blind placebo-controlled clinical trials.

Including Actiful® in your formulation: top 6 reasons

If you are thinking of including Actiful® in your formulation, you must know the following:


1. It has been clinically tested in both young and senior subjects.

When the common goal is being more active, Actiful® is the ideal ingredient for both young and senior subjects.

The efficacy of Actiful® was first demonstrated in a 4-week randomized, placebo-controlled, double-blind clinical study conducted with young subjects. The results show that immediate and sustained energy improved significantly for the supplementation group compared to placebo [1].

In another clinical trial, the objective was to measure the effect of Actiful® on energy and mental wellness in seniors. As expected, anaerobic power significantly improved in the supplementation group [2].

Interestingly, the WHO Quality of Life scores on mental wellness significantly increased in the Actiful® group, compared to the placebo.


2. It boosts the NO levels, thereby improving the blood flow.

The active flavonoids in sweet orange, the major component of Actiful®, were found to activate the phosphorylation of Endothelial Nitric Oxide Synthase (eNOS). eNOS is the key enzyme for Nitric Oxide (NO) synthesis [3]. Consequently, NO increases, which positively affects the endothelium by promoting vasodilation and increasing blood flow.

As a direct consequence of the improved blood flow, oxygen and nutrients are more efficiently transported to the body districts where required.

Pomegranate further augments the production of NO as it is an excellent donor of highly bioavailable nitrate.


3. It works directly at the mitochondrial level.

Experiments in myotubes showed that hesperitin, the active flavanone derived from the metabolization of Actiful®, enhances ATP production at the mitochondrial level [4].

By quenching the reactive oxygen species (ROS) and reducing proton leakage between the intermembrane space and the mitochondrial matrix, Hesperitin can improve the proton gradient required for the ADP-ATP phosphorylation cycle.

This process results in a better respiration capacity of the mitochondria, leading to more ATP production, the fuel for our muscles.


4. It acts on the body as well as on the mind.

Mood is a crucial aspect of every individual’s well-being. Stress, anxiety, focus and happiness are all factors that affect our psychophysical wellness.

It was demonstrated that the supplementation with Actiful® not only positively affects the energy level, but it may also affect the mood.

As it is clear that body and mind work in tandem, Actiful® can be considered the perfect vitality enhancer!


5. High bioavailability is proven.

Bioavailability is an important aspect to consider in nutraceuticals, as it is a key indicator of absorption and directly influences the bio-activity of specific molecules.

Actiful® was developed with this concept in mind, and a human and in vitro study demonstrated that the active ingredient starts to be taken up by the body within minutes [5].

Furthermore, the active metabolites remain available for several hours after consumption. Hence, Actiful® offers excellent potential for a significant immediate energy boost, maintained over time after consumption.


6. It is patent-protected.

Actiful® is an innovative and patent-protected ingredient. Solabia Nutrition is a pioneer in researching the positive effect of citrus flavonoids on energy metabolism.

This further adds value and makes Actiful® even more unique. Why? Because you won’t find imitations in the marketplace.

If you are interested in learning more about Energy & Vitality – Trends, Clinical Research and Innovation, you should check out our webinar on this topic. Click here to view!

micro algae for longevity

Top 3 reasons to add astaxanthin to your product formula

Top 3 reasons to add astaxanthin to your product formula

Maastricht, 7th June, 2024

Astaxanthin is a powerful red carotenoid antioxidant naturally produced by the microalgae Haematococcus pluvialis. It is one of the most potent antioxidants and much stronger than other carotenoids. Therefore, it is a popular choice for inclusion in supplements targeting cellular health and longevity.

micro algae for longevity

Top 3 benefits of astaxanthin


  1. Astaxanthin decreases oxidative stress

Astaxanthin helps to significantly reduce oxidative stress by neutralizing free radicals and reactive oxygen species (ROS) (1). Its unique molecular structure, which allows it to span across cell membranes, enhances its ability to protect cells from lipid peroxidation and DNA damage. Astaxanthin also boosts the body’s natural antioxidant defenses by upregulating the activity of enzymes, thus providing a comprehensive shield against oxidative damage and supporting overall cellular health (2).


  1. Astaxanthin for Skin Health

Astaxanthin promotes skin health by protecting skin cells from damage and supporting a youthful appearance (3). The skin is exposed to numerous internal and external factors that cause damage, such as sun exposure, pollution, and toxins, which lead to the production of ROS. These ROS can degrade collagen and damage DNA, resulting in sunburn, wrinkles, and age spots. Clinical studies have shown that astaxanthin improves skin appearance by reducing hyperpigmentation, decreasing skin water loss, increasing elasticity, and protecting against UV radiation (4).


  1. Astaxanthin for Eye Health

The eyes are particularly vulnerable to oxidative stress due to their exposure to light, high content of mitochondria, and the metabolic rate of photoreceptors (5) . Oxidative stress is linked to various eye diseases and retinal disorders. Fortunately, astaxanthin crosses the blood-retinal barrier, helping to protect the eyes from oxidative stress and inflammation. Clinical studies have shown that astaxanthin improves blood flow in the eye’s small vessels and reduces eye fatigue and strain from prolonged screen exposure (6).



Astaxanthin’s strong antioxidant and anti-inflammatory properties make it a valuable addition to any product aimed at cellular, skin, and eye health.

WATTS'UP® in sports nutrition supplement

6 reasons to use WATTS’UP® in your sports nutrition supplement

6 reasons to use WATTS’UP® in your sports nutrition supplement

Last updated: April 19th, 2024

July 14th, 2023

Over the past years, the consumption of dietary supplements has become more widespread amongst both athletes and non-athletes. Athletes, in particular, have taken to these supplements to boost their athletic performance, speed up recovery, and prevent injuries. For product developers, it can be hard to decide which ingredients to include in their sports nutrition supplements. In this article, you will get to know more about the health benefits of our citrus extract WATTS’UP® and 6 reasons to include it in your sports nutrition supplement.

WATTS'UP® in sports nutrition supplement

Beneficial effects of antioxidants for sports nutrition

Polyphenols are molecules present in many fruits. They have attracted attention for their ability to act as antioxidants and reduce inflammation [1]. Studies have shown that polyphenols from citrus, pomegranates, and blueberries can alleviate muscle pain after exercise and enhance muscle strength [2].

Additionally, flavonoid supplementation has been found to enhance endurance exercise performance in humans.

Therefore, Solabia Nutrition, previously known as BioActor, researched and developed a unique sports nutrition ingredient called WATTS’UP®. This is a natural ingredient, extracted from Citrus sinensis and standardized for highly bioavailable hesperidin.

WATTS’UP® has been designed to improve performance in both endurance and strength disciplines, making it a high-quality ingredient for supplements in the sports nutrition market. For this reason, we would like to delve into 6 reasons to use it in your sports nutrition supplement.

1. WATTS’UP® increases production of nitric oxide for optimal blood flow

Hesperidin, the main component in WATTS’UP® can boost the cells that form the lining of our blood vessels by promoting the production of nitric oxide [3]. This substance induces the muscles in our blood vessels to relax and expand, facilitating blood flow.

As a result, blood circulation increases leading to a decrease in blood pressure, as well as an increase in the supply of oxygen and nutrients to the muscles during physical activity, thereby reducing fatigue.

2. WATTS’UP® directly affects the mitochondria

The mitochondria play a vital role in providing energy obtained from food into ATP (Adenosine Triphosphate), which is the energy source that the muscles need for physical activity [4].

Inside the muscle cells, WATTS’UP® increases the efficiency of mitochondria, allowing these organelles to produce much-needed energy in a more efficient way [3]. Simply put, WATTS’UP® makes sure that the mitochondria do not lose any of their potential to create energy, meaning that less energy is lost without the production of ATP.

3. WATTS’UP® increases sports performance in trained athletes and recreational gym-goers

Performance booster for trained athletes

A placebo-controlled double-blind study investigated the long-term effect of a daily dose of 500mg of WATTS’UP® supplementation on highly trained athletes.

After 4 weeks of supplementation with 500mg of WATTS’UP®, a strong increase in anaerobic power (p=0.03) was observed, as well as a sustained superior aerobic-derived power throughout the whole exercise. The tested individuals spent 10 hours per week biking, meaning that even in highly trained individuals, WATTS’UP® can give you the power to go that extra mile.

Performance booster for moderately trained individuals

Furthermore, a placebo-controlled and double-blind study investigated the effect of a daily dose of 400mg of WATTS’UP® on peak power in moderately trained subjects.

The results showed an increase in average peak power (p<0.001) as well as a significant increase in peak power within the first five seconds (p=0.020) after 4 weeks of supplementation. This means that WATTS’UP® is not only able to help highly trained individuals, but also gym-goers.

Read more about these studies in our white paper for WATTS’UP®.

4. Higher bioavailable

WATTS’UP® was specifically developed and has been micronized for improved bioavailability and rapid uptake [5].

To illustrate, a bioavailability study in humans showed that metabolites of WATTS’UP® reached the bloodstream after only 15 minutes of consumption to boost performance right from the start, enhancing the power during the exercise.

This makes WATTS’UP® a great ingredient to include in your sports nutrition supplement.

5. Natural powder and easy to formulate

WATTS’UP® is a clean and natural ergogenic sports performance ingredient, which is why it is a great addition to boost any sports nutrition formula. It has a neutral taste and is easily combined with electrolytes, BCAAs, creatine or caffeine in powder blends, capsules, effervescent tablets, beverages, and gummies.

Curious about which ingredients a pre-workout formula should include? Find out more!

6. WATTS’UP® is sustainably sourced

Moreover, WATTS’UP® is made from immature oranges that are sustainably sourced. During the growth of an orange tree, the tree has to decide which fruits are the most promising ones. To sustain these high-quality oranges, the tree has to allocate its resources to them. This means that the less promising oranges are dropped from the tree in a process that’s called ‘Fruit drop’.

That these immature oranges are dropped, does not mean that they are not full of valuable nutrients! For this reason, we collect this byproduct of orange trees to create our citrus extracts.

Read more about this process here!

WATTS’UP®, the key ingredient for your sports nutrition supplement

In summary, WATTS’UP® increases aerobic and anaerobic power through a direct effect on the mitochondria showing positive effects on peak force, anaerobic power, and endurance performance. Therefore, this ingredient is the ideal sports supplement for both trained athletes and active people who want to get nutritional support for their physical exercise.

Because it is an innovative and science-based ingredient, it will add differentiation and help your supplement of getting a defined and solid positioning on the market. This makes WATTS’UP® an important ingredient in creating a successful sports supplement product.

Discover YAMAMOTO’s Success Story

Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.


Hesperian supports mitochondrial function

How can we support mitochondrial function?

How can we support mitochondrial function?

Maastricht, 14th April, 2024

Supporting mitochondrial function is essential for maintaining overall health. Mitochondria serve as the cell’s powerhouses, responsible for energy production. Thus, maintaining mitochondrial health is key to cellular vitality and well-being.

Hesperian supports mitochondrial function

The Key to Enhanced Mitochondrial Function

Hesperidin, a flavonoid abundant in citrus fruits (1), exerts multiple positive effects within cells. It acts as an effective scavenger of free radicals, safeguarding cells from oxidative damage. Specifically, hesperidin impacts mitochondrial function through several pathways:


Enhanced Efficiency: Research suggests hesperidin can boost mitochondrial efficiency, leading to improved cellular energy production (2).

Mitochondrial Protection: Hesperidin’s antioxidant properties are pivotal in shielding mitochondria from oxidative damage. It scavenges harmful radicals and helps preserve mitochondrial integrity, preventing dysfunction induced by oxidative stress (3).

Improved Resilience: Studies suggest hesperidin enhances mitochondrial resilience against various stressors, including environmental toxins and metabolic challenges (3). By reinforcing mitochondria’s adaptive capabilities, hesperidin supports overall cellular health and longevity.

Reduced Inflammation: Chronic inflammation can compromise mitochondrial function and induce cellular damage. Hesperidin’s anti-inflammatory properties help mitigate inflammation, indirectly supporting mitochondrial health (4).

Cardiovascular Benefits: Some research indicates hesperidin may support cardiovascular health by enhancing mitochondrial function in cardiac muscle cells (5), potentially improving heart function and overall cardiovascular wellness.

Incorporating hesperidin-rich foods or supplements into your diet may provide a natural means to support mitochondrial health and enhance overall well-being.


How to Support Mitochondrial Health?

Various lifestyle choices can elevate hesperidin levels in the body, promoting overall health:

  • Dietary Choices: Consuming a diet abundant in citrus fruits is the primary strategy to boost hesperidin intake (6). Oranges, lemons, and grapefruits are excellent sources of this flavonoid. Incorporating these fruits into daily meals or snacks can significantly elevate hesperidin levels.
  • Fresh and Whole Foods: Opt for fresh and minimally processed foods to maximize hesperidin content (7). Freshly squeezed citrus juices and whole citrus fruits contain higher hesperidin levels than packaged or processed alternatives.
  • Cooking Methods: Choose cooking methods that preserve hesperidin content. Lightly steaming or stir-frying vegetables retains more hesperidin compared to boiling, which can leach out the flavonoid.
  • Supplementation: Hesperidin supplements, available as capsules or tablets, offer a concentrated source for those not getting enough through diet alone (8).
  • Physical Activity: Regular exercise can increase the bioavailability of flavonoids like hesperidin. Exercise improves blood circulation and metabolism, potentially enhancing hesperidin absorption and utilization.



Overall, hesperidin emerges as a valuable natural compound with the potential to support mitochondrial health and counteract oxidative stress-related disorders. Incorporating hesperidin supplementation or making dietary changes to increase hesperidin intake can further amplify these positive effects.

supplement to slow down aging

Actiful®: a key ingredient for healthy aging

Actiful®: a key ingredient for healthy aging

Maastricht, 29th January 2024

Are you looking for an impactful science-based ingredient to add to your energy and vitality supplement? Well, look no further as the research-based evidence is expanded on the key role of Actiful® in supporting energy production, improving mental wellness, and reducing oxidative stress.

supplement to slow down aging

How can we slow down the aging process?

Aging is a complex process (1) characterized by a gradual decline in physiological function and an increased susceptibility to various diseases. It encompasses a range of biological, psychological, and social changes that occur over time. At the cellular level, aging involves factors such as mitochondrial dysfunction and accumulation of damage from oxidative stress. These processes contribute to a decline in the efficiency of cellular repair and maintenance mechanisms.


Factors impacting the aging process

Additionally, genetic and environmental factors play significant roles in influencing the rate of aging. While aging is a natural and inevitable part of life, lifestyle choices, such as diet, exercise, and stress management, can impact the rate at which the aging process unfolds. Continuous research is taking place to study aging and better understand potential interventions to promote healthy aging and longevity (2).


A combination of diet and supplementation

Slowing down the aging process involves adopting a holistic approach that addresses various aspects of one’s lifestyle. A balanced and nutritious diet rich in antioxidants, vitamins, and minerals is crucial for maintaining cellular health and preventing oxidative stress. Regular exercise, adequate sleep and stress management can positively impact both mental and physical health (3). Avoiding harmful habits such as smoking and excessive alcohol consumption is also vital, as they accelerate the aging process.


Combining these lifestyle factors and taking appropriate supplements can create a foundation for a healthier and more vibrant aging experience. Adding supplements to the diet can be beneficial for healthy aging, as they can help address specific nutrient deficiencies and support overall well-being. They are often recommended for digestive health, immune support or cell function optimization. (4, 5)

mitochondria health and energy and healthy aging

Actiful®: clinically proven ingredient for healthy aging

Actiful® is a patent-protected plant-based ingredient for improved energy production, mental wellness and mitochondria support. It is standardized for hesperidin which is a key polyphenol extracted from sweet oranges (Citrus sinensis). Actiful® also contain pomegranate (Punica granatum), known to be rich in nitrate and useful for NO production, leading to vasodilation. Previous clinical data has already shown the beneficial properties that the combination of these polyphenols has in terms of enhanced physical performance (6, 7), mental health support (7), improved energy production by the mitochondria (8) and improved blood flow (9).

Recent clinical data further underlines the benefits that Actiful® brings to the table. The combination of hesperedin and pomegranate in a 350mg supplement capsule was provided to healthy seniors for 4 weeks in a randomised, blinded, placebo-controlled manner. In the end of the intervention period, the concentration of methylglyoxal (MGO) in the blood decreased by ≈ 10% (10). This is a statistically significant and clinically relevant result as MGO accumulation in cells leads to cellular disfunction and shorter cell life. Clearly, you would like to stimulate MGO scavenging, if you are targeting healthy aging. 


The role of Actiful® in supporting the mitochondria

The mechanism of action of the polyphenols present in Actiful® is quite complex and apparently linked with benefits and protection for our mitochondria, the so called ‘powerhouse’ of the cells. Hesperidin and pomegranate are known for their antioxidant properties (11, 12), which contributes to the direct MGO scavenging. They also reduce oxidative stress which leads to support of the natural body’s detoxification mechanisms. All of the above mentioned benefits are directly linked with the potential of Actiful® to protect the mitochondria and support its function via the reduction of MGO, observed in the latest clinical data of Actiful® (10).


The potential of Actiful® for the supplements market

The latest data allows Actiful® to expand its market possibilities. It can be an active ingredient in vitality supplements for mid-aged adults and active seniors as well as in energy drinks and sports drinks. Actiful® can be marketed for its beneficial effects on vitality, mental wellbeing, energy production and mitochondria support.

men health

Top 5 ingredients for men's health

Top 5 ingredients for men’s health

October 30th, 2023

Incorporating health ingredients into daily routines helps to support men’s well-being and health. We will provide you with evidence-based recommendations on five key ingredients supporting men’s health and sexual function, including fenugreek seed extract, zinc, B vitamins, pomegranate extract, and hesperidin.

men health

In today’s fast-paced world, prioritizing our health and well-being is becoming more and more important, also for men. As the increasing expectations and pressures of our lives continue to evolve, it is important for men to develop a proactive approach to maintain their physical, mental, and sexual health.

Health ingredients are designed to meet men’s health needs, ensuring that they stay healthy and full of energy. In this article, we will provide evidence-based recommendations on five key ingredients supporting men’s health and sexual function.

Fenugreek seed extract

As men age, they experience a decrease in testosterone levels. This phenomenon is also known as andropause. Testosterone plays a role in many aspects of health, including sexual function, muscle and bone mass, energy levels, and metabolism. One of the ingredients that may help to combat the problems related to andropause is fenugreek seed extract . Fenugreek (Trigonella foenum-graecum) is a very interesting herb with many potential health benefits.

A study performed on 120 healthy men showed that a 12-week supplementation of fenugreek seed extract (600 mg/day) increased testosterone levels and improved sexual function, compared to placebo [1]. Also, supplementation of fenugreek seed extract in healthy male athletes resulted in increased fat-free mass, lean body mass, and elevated testosterone levels compared to placebo [2]. These findings suggest that fenugreek seed extract is a promising ingredient for men’s health, especially in terms of increasing testosterone levels and improving sexual function.


Zinc is an essential mineral, which means that it is not produced by the body itself. It plays an important role in many physiological functions, such as supporting the immune system and healing damaged cells. Zinc is a critical mineral for men’s health as even a small deficiency can impact the immune system, cardiovascular health, reproductive function, and fertility [3].

Sufficient intake of zinc contributes to normal fertility and sexual function in males. Low levels of zinc are related to low levels of testosterone. Besides, it is also important for the normal functioning of the immune system, and the maintenance of bone health [4].

Therefore, we can state that zinc is an important mineral that can help men improve their sexual health and energy levels and maintain a healthy immune system.

B Vitamins

B vitamins play a vital role in the human body. They are involved in many important functions. For example, they are crucial for energy production, oxygen support, and bone health.

The vitamin B complex consists of a total of eight B vitamins, with several of them having beneficial effects on men’s health, for example:

Vitamin B12: Adequate levels of vitamin B12 are important for the production of red blood cells, which are responsible for oxygen transport. Also, studies showed that vitamin B12 is important for bone health [5, 6].

Vitamin B9: Vitamin B9, also known as folate, is not only an important vitamin for women but also for men. Research has shown that folate contributes to the reduction of fatigue, which is a common complaint nowadays [7].

Vitamin B6: Vitamin B6 plays a vital role in energy and vitality. Intake of this vitamin contributes to normal energy metabolism. Studies also showed that it leads to a decrease in fatigue and tiredness [8].

Vitamin B5: Pantothenic acid, also known as vitamin B5 is an essential vitamin, which plays a vital role in various functions in the body. It is mainly known for its important role in the metabolism of food, leading to energy production [9].

All in all, B vitamins are important for energy production. Increased energy levels lead to improved stamina and sexual performance.

Pomegranate extract

Pomegranate (Punicagranatum L.) is a fruit that contains lots of healthy phytochemical compounds, such as polyphenols, flavonoids, and nitrates [10]. These phytochemicals have many antioxidant and anti-inflammatory qualities beneficial for men’s health [11].

The polyphenols within pomegranate fruit are the main bioactive compounds responsible for the various health benefits attributed to this extract. The peel of the pomegranate contains the highest amounts of polyphenols. Two of the primary polyphenols in the peel are ellagitannins (punicalagin and punicalin) and ellagic acid [12].

Studies showed that pomegranate extracts are associated with the treatment and prevention of many diseases and disorders in men , such as cardiovascular diseases, infertility, and erectile dysfunction [13, 14, 15]. For example, pomegranate has a positive effect on blood flow, key for erectile function and sexual performance [16].


Hesperidin is a bioflavonoid found in citrus fruits, abundant in sweet oranges (Citrus sinensis). After ingestion, hesperidin is converted to hesperetin by the microbiome. Hesperetin is considered the active metabolite of hesperidin and has been shown to have several beneficial health effects for men.

One of the health effects of hesperidin is that it has antioxidant activity, through neutralizing Reactive Oxygen Species (ROS) [17]. This may eventually lead to enhanced overall well-being and an increase in energy when you need it most. This antioxidant activity also has a positive effect on fertility in men, since free radicals (ROS) decrease sperm motility and increase DNA damage [18].

Additionally, hesperidin is known for its positive effect on blood flow. The active ingredient achieves this by increasing the availability of nitric oxide [19]. Eventually, this leads to an improved supply of nutrients and oxygen during physical and sexual activity, and to an improved erectile function.

Actiful®: An ingredient containing hesperidin and punicalagin

Actiful® is a natural orange and pomegranate complex and is standardized for highly bioavailable hesperidin and punicalagin: the primary polyphenols present in sweet orange (Citrus sinensis) and pomegranate peel (Punica granatum).

The health benefits of this ingredient have been scientifically validated and confirmed through multiple randomized double-blind controlled trials. It is clinically proven that Actiful® results in enhanced physical performance in men [20, 21].

Actiful® not only influences physical performance. It also boosts energy levels by targeting the mitochondria within the cells [22]. Additionally, Actiful® has been demonstrated to positively impact mental health [19].

Lastly, it has been shown that Actiful® positively affects blood flow [21], by increasing the availability of nitric oxide. Hereby it promotes improved erectile function in men, leading to longer-lasting erections.

Overall, Actiful® stands as a promising and scientifically backed choice for men aiming to improve their physical performance, sexual function, and overall health.