bonolive support women health

Everything you need to know about Bonolive® and women's health

Everything you need to know about Bonolive® and women’s health

Maastricht, 29th March, 2024

bonolive women health oleuropein

How do we define women’s health?

Woman’s health encompasses a range of physical, emotional, and mental aspects. Good health allows women to engage in daily activities with ease and vitality. It enables them to pursue their goals, whether personal or professional, without being limited by health issues. Hence, women’s quality of life is largely dependent on their health and mental status (1, 2).

A pivotal milestone in a woman’s life is the menopause, primarily characterized by hormonal fluctuations, particularly a decrease in oestrogen levels. This hormonal imbalance may have implications for women’s physical and mental health. However, with proper support and a holistic approach, the individual needs of each woman can be catered for.

How can we support women’s health (particularly during menopause)?

Women’s quality of life benefits from a holistic approach, including a comprehensive and integrated plan that addresses physical, mental, emotional, and social aspects of well-being (3). The top 3 strategies to support women’s health are listed below:

  1. Nutrition: Encouraging a balanced and nutritious diet is fundamental to women’s health. Emphasize whole foods, plenty of fruits and vegetables, lean proteins, healthy fats, and whole grains. Proper nutrition supports hormone balance, bone health, immune function, and overall vitality (4).
  2. Regular Exercise: Physical activity is essential for maintaining a healthy weight, reducing the risk of chronic diseases, improving mood, and enhancing overall well-being (5). It is advisable for women to engage in regular exercise that they enjoy, whether it’s walking, swimming, yoga, or strength training.
  3. Stress Management: Chronic stress can negatively impact women’s health. Teach stress management techniques such as mindfulness meditation, deep breathing exercises, yoga, or progressive muscle relaxation. Encouraging women to prioritize self-care activities would help them relax and unwind.

Exploring nutritional solutions for women’s health

As explained above, nutrition is a top priority to maintain and support health status. If we zoom in on women’s needs during peri- and post-menopause, we can explore in more detail what are the micronutrients that could provide a benefit during this stage of life. Typically, menopause is accompanied by acute symptoms such as bloating, night sweats, hot flashes, and long-term ones like loss of bone mineral density or imbalance in blood lipid profile.

Fortunately, there are quite a few nutritional strategies to explore in terms of lowering the risk of the above-mentioned conditions (6). For example, the sufficient intake of omega 3 and 6 fatty acids (7) is important for lipids metabolism as well as skin health. Furthermore, vitamin D (8) contributes to mineral turnover and bone health. In addition, olive polyphenols like oleuropein have great potential to support women in menopause by lowering the risk of bone loss and alleviating joint pain (9, 10).

What is oleuropein?

Oleuropein is the primary polyphenol found in olives and olive leaves (11). It contributes to the bitter taste of olives, especially the unripe ones. This compound has gained recent attention due to its potential health benefits for the human body such as anti-inflammatory and antimicrobial properties (12). Research suggests that it could support cardiovascular health by improving blood lipid levels. Oleuropein is also studied for its potential to aid bone health and skin health as it may reduce chronic inflammation. Moreover, Solabia Nutrition is the pioneer in research innovations with oleuropein and it is now under investigation for supporting women’s health, especially during and post-menopause.


How can oleuropein support women’s health?

Oleuropein may offer several potential benefits for women’s health during various stages of life, including menopause. Here’s how oleuropein can support women’s health:

  • Bone Health: During menopause, women are at an increased risk of osteoporosis due to declining estrogen levels. Oleuropein has been shown to promote bone health by stimulating osteoblast activity (cells responsible for bone formation) and inhibiting osteoclast activity (cells responsible for bone resorption) (13). By supporting bone density and strength, oleuropein may help reduce the risk of osteoporosis and fractures in postmenopausal women.
  • Cardiovascular Health: Cardiovascular risk increases after menopause, partly due to changes in hormone levels. Oleuropein has been found to have cardioprotective effects, including lowering blood pressure, reducing LDL cholesterol levels, and improving endothelial function (the function of blood vessel lining) (14). These benefits may help support heart health in women, particularly postmenopausal women.
  • Anti-inflammatory Effects: Menopause is associated with increased inflammation in the body, which may contribute to various health issues such as joint pain, cardiovascular complications, and cognitive decline. Oleuropein has potent anti-inflammatory properties that can help reduce inflammation and oxidative stress, potentially alleviating symptoms and reducing the risk of chronic diseases associated with inflammation.
  • Immune Support: The immune system can undergo changes during menopause, potentially leading to increased susceptibility to infections and immune-related conditions. Oleuropein exhibits antimicrobial properties and may help support immune function by inhibiting the growth of bacteria, viruses, and fungi (14). By bolstering the immune system, oleuropein may contribute to maintaining women’s health and resilience to infections.
  • Hormonal Balance: Although more research is needed, some studies suggest that oleuropein may potentially help alleviate menopausal symptoms such as hot flashes, mood swings, and skin dryness by modulating hormone levels.
  • Skin Health: oleuropein holds promise in lowering skin inflammation and supporting skin hydration due to its moisturising and antimicrobial properties (14, 15). vigorous research is currently ongoing in this area, as technological advancements allow for accurate monitoring of improvements in skin health parameters.

Is oleuropein scientifically proven to support women?

There are numerous clinical studies assessing the effects of oleuropein. However, BioActor is the first and only to design clinical studies in the context of women’s health. Three publications in international peer-reviewed journals are testimony of BioActor’s trailblazing research for women’s health. So far, oleuropein emerged as a promising ingredient to support women peri- and post-menopause.

  1. Firstly, a 12-month oleuropein intake resulted in a significant increase in osteocalcin, a marker for bone formation (12). The intervention group also maintained bone mineral density. Additional outcomes were the significant reduction in LDL-cholesterol and total triglycerides in the intervention group, compared to placebo.
  2. Secondly, pain during walking was significantly decreased after 6 months intervention compared to baseline (16). Importantly, oleuropein intake was well tolerated, therefore it may be considered for long-term intake to relieve joint discomfort and improve mobility.
  3. Moreover, postmenopausal women exhibited elevated blood plasma concentrations of Bonolive® metabolites. These findings suggest that the bioavailability of Bonolive® is particularly high in post-menopausal women compared to pre-menopausal women (17). Moreover, MDA a marker for antioxidant status significantly improved in post-menopausal women.

Overall, oleuropein has already shown excellent potential in supporting women’s health and menopause concerns. Therefore, our research group continues to investigate the effects of this ingredient on factors related to women’s health and menopause.


What is Bonolive®?

Bonolive® is Solabia Nutrition’s patented olive leaf extract standardized for high levels of oleuropein. This all-natural ingredient is clinically validated in post-menopausal women to support women’s health during post-menopause, notably by:

  • Enhancing the number and activity of bone-producing cells (osteoblasts)
  • Stabilizing bone mineral density (18)
  • Improving blood lipids/lowering bad cholesterol
  • Improving mobility/reducing joint pain
  • Alleviating menopause symptoms related to mood and skin appearance (19, 20).


The history of Bonolive®

It all started with the breakthrough research of Professor Veronique Coxam on the bone protective properties of oleuropein at the French research institute INRA. Her colleague Marie-Noelle Horcajada continued working on the joint health benefits of Bonolive® at Nestlé Health Science. In parallel, BioActor’s CSO, Dr Yala Stevens and principal scientist Maria Imperatrice have been spearheading the research on Bonolive’s bioavailability and peri-menopause-related effects. More than 150 women took part in our studies as volunteers.


How are the olive leaves sourced?

Olive leaves provide the oleuropein present in Bonolive®. The olive plantation that provides the leaves for Bonolive® is situated near Cordoba, Spain. During the pruning season, the fresh leaves are collected and stored in a special environment to preserve the oleuropein content for extraction. This is an upcycling process, with the olive leaves being a clean and environmentally friendly source of oleuropein for Bonolive®.

Who can benefit from taking Bonolive®?

Bonolive® is a high-quality, 100% clean and scientifically backed ingredient, designed for women by women. Bonolive® targets specifically women in peri- and post-menopause, who need tailored support throughout this important life stage (21). Our latest consumer study suggests that women experiencing acute symptoms such as hot flashes, mood swings, and night sweats may notice improvements after just two weeks of use (22).

Easy formulation options with Bonolive®

Bonolive® is a great addition to any product formulation targeting women’s health, specifically menopause concerns. It has a convenient clinically validated dose of 250 mg which fits quite well in capsules. This ingredient is also lipids- and water soluble and can be formulated into softgels, effervescent tablets or beverages. It is also suitable for direct compression in the form of tablets.

Current products on the market often combine Bonolive® with other minerals, vitamins and botanicals suitable to support women’s health such as calcium, magnesium, iron, vitamins B, C & D etc. Our team can also offer formulation advice and guidance according to your specific projects.


Bonolive® is a safe solution for menopause support

Moreover, Bonolive® is well tolerated and suitable for long-term consumption to support menopausal women. Bonolive does not contain oestrogens, as opposed to isoflavones. BioActor commissioned extensive safety studies with Bonolive that have been published in a peer-reviewed journal. Recently, the US FDA approved the GRAS status of Bonolive for inclusion in functional foods and beverages, further affirming its high quality and safety standards.

Bonolive® is a finalist at NutraIngredients

Bonolive® is selected as a finalist for Innovations in Women’s Health NutraIngredients Award!

Maastricht, 28th March 2024

Solabia Nutrition’s revolutionary ingredient, Bonolive®, selected as a finalist for NutraIngredients Award in Innovation for Women’s Health!

bonolive innovation in women's health award

Solabia Nutriton is proud to announce that Bonolive® has been selected as a finalist for the prestigious NutraIngredients Award in Innovation for Women’s Health! Bonolive®’s exceptional contributions to women’s wellness have garnered recognition from industry experts and consumers alike.

Bonolive® is Solabia Nutrition’s patented olive leaf extract, standardized for high levels of oleuropein. It proudly stands as the only oleuropein ingredient patented specifically for women’s health, setting a new standard in innovation. This achievement is well deserved as Bonolive® has undergone several clinical trials in women, particularly during menopause, demonstrating its profound efficacy in supporting their health. Developed by an entirely female-led team, Bonolive® embodies a commitment to women’s wellness like no other.

This achievement underscores Solabia Nutrition’s commitment to advancing nutritional science and empowering individuals to live healthier, more vibrant lives. We extend our heartfelt gratitude to the NutraIngredients panel for this esteemed nomination.

Stay tuned as we eagerly await the final results of the NutraIngredients Awards ceremony during VitaFoods Europe in May 2024!

Feel free to contact us for more information on the possibilities Bonolive® has to offer.

Further information can be found on:


    Nutritional strategies to relieve menopause symptoms

    Nutritional strategies to relieve menopause symptoms

    Last updated: March 22nd, 2024

    March 16th, 2023

    During and after menopause, many women experience uncomfortable symptoms such as bloating, hot flashes, and night sweats. While hormonal therapy can help alleviate symptoms, it may also have side effects. Therefore, more attention is being given to changes in diet or the use of natural supplements. This article will explore nutritional strategies that may provide relief from menopause symptoms.


    Foods to alleviate menopause symptoms

    As women approach menopause, a lot of changes occur. Their estrogen levels decrease, leading to various symptoms such as bloating, night sweats, anxiety, or depression.

    Menopause can also increase the risk of cardiovascular diseases and bone loss, which are commonly ignored. However, making some dietary changes can be an effective and easy way to alleviate these symptoms. In this article, we will discuss five foods that can help ease menopause symptoms.

    1. Fish rich in n-3 PUFAs for menopause support

    Fish is a great source of healthy and essential fatty acids, including omega-3 polyunsaturated fatty acids (n-3 PUFAs) that have protective effects and anti-inflammatory actions. These fatty acids are found in fatty fish like salmon and some algae species.

    Research has shown that consuming fish or fish oil can reduce depression, anxiety (1), hot flashes, and sleeping problems (2) in menopausal women. In addition, fatty fish is rich in vitamin D, which is essential for calcium absorption and maintaining bone health.

    If you don’t eat fish, you can still get the benefits of n-3 PUFAs by consuming foods rich in α-linoleic acid (ALA), which our bodies can convert into these beneficial fatty acids. ALA has been shown to improve skin hydration and smoothness and can be found in foods like flaxseeds, almonds, walnuts, and chia seeds (1), as well as soy products that we’ll discuss later.

    2. Olive leaf extract for menopausal symptoms

    Olives contain (poly)phenolic compounds that have many positive effects, including antioxidant, anti-inflammatory, and anticancer properties (3).

    Interestingly, olive leaves contain significantly higher concentrations of phenolic compounds than olives or olive oil (4). As a result, they may have even greater potential for exerting beneficial effects on health. In fact, research has already demonstrated that taking olive leaf extract daily can be an effective alternative treatment for reducing blood pressure in individuals with hypertension (5).

    One of the key phenolic compounds found in olive leaf extract is oleuropein, which has been shown to significantly impact women’s health during post-menopause. Oleuropein has been proven to reduce cholesterol levels, lower the risk of bone loss, alleviate joint pain, improve skin health and enhance mobility (6,7).

    Bonolive® is an olive leaf product that is standardized for high levels of oleuropein.

    3. Soy products

    Soy products, including soy milk, soybeans, and tofu, are rich in isoflavones, which are plant-derived estrogens and selective modulators of estrogen receptors in the body. These properties make soy products a promising alternative to hormonal therapy.

    Soybeans contain essential fatty acids, such as ALA (α-linoleic acid), that have anti-inflammatory properties. Additionally, soy protein has been found to reduce bad cholesterol levels, which can lower the risk of cardiovascular diseases (8).

    One of the isoflavones found in soybeans is genistein, which is structurally similar to female estrogen and can alleviate menopausal hot flashes. Another isoflavone, daidzein, can inhibit cell proliferation in the gastrointestinal tract, potentially reducing the risk of estrogen-sensitive cancers, such as ovary, prostate, and breast cancer (9).

    4. Yogurt to support menopause

    Yogurt is a nutrient-rich food that contains calcium and vitamin D, which are important ingredients to improve bone health during menopause. Bifidobacterium bifidum and Lactobacillus acidophilus, which are considered ‘good’ bacteria, are used to make yoghurt and they are also present in the final product, making yogurt a source of probiotics that can benefit gut health.

    Research has shown that consuming extra probiotics in yogurt can help to reduce anxiety and stress levels, and improve overall quality of life compared to regular yogurt (10). However, regular yogurt also has similar long-term effects. Additionally, yogurt may have a role in appetite control, making it a helpful food for weight management (11).

    Studies have suggested that a well-balanced diet that includes milk and dairy products, like yogurt, may also improve sleep quality (12).

    How can foods help with menopause symptoms?

    To summarize, consuming fish, soy products, whole grains, olive leaf extract, and yogurt can promote healthy cholesterol levels, maintain bone mass, reduce menopausal symptoms such as hot flashes and mood swings, and help regulate appetite and blood sugar levels. If you’re experiencing menopausal symptoms, these natural products are worth considering.

    bonolive safe FDA GRAS

    FDA GRAS Approval for Bonolive®

    Bonolive® – Solabia-BioActor’s innovative women’s health ingredient, receives FDA GRAS approval

    Maastricht, 6th March 2024


    The United States Food and Drug Administration approves Bonolive® as safe for inclusion in supplements, beverages and functional foods. 

    Bonolive safe foods supplements

    Solabia-BioActor received а no objections letter from the U.S. Food and Drug Administration (FDA) regarding their Generally Recognized as Safe (GRAS) application for its women’s health ingredient Bonolive®. The FDA approves Bonolive® for inclusion in Dietary Supplements, Beverages and Functional Foods. 

    For access to the FDA “no objection letter” please follow this link.

    GRAS is a designation created by the FDA under the Federal Food, Drug and Cosmetic Act. It is a testament to the safety of a food ingredient or additive based on adequate evidence. Bonolive® had already shown a clean safety profile in published tox studies and a GRAS panel had concluded that Bonolive® should be considered GRAS.

    Bonolive® is an oestrogen-free, patented ingredient, standardised for high levels of oleuropein. This all-natural ingredient is clinically validated in post-menopausal women to support women’s health during post-menopause. Human intervention studies showed that Bonolive® plays a key role in:

    • stimulating bone-building cells (osteoblasts) and stabilising bone mineral density
    • improving blood lipid profile
    • reducing joint pain and improving mobility.

    A recent consumer study in menopausal women also showed that Bonolive® helps alleviating menopause related symptoms related to mood and skin appearance. Interestingly, a pharmacokinetics study showed that Bonolive® has an enhanced bioavailability in post-menopausal women.

    Bonolive® targets women in peri- and post menopause that are looking for a safe, natural and oestrogen-free solution to the challenges of menopause. It is a true innovation as the only clinically evaluated olive leaf extract for women’s health. This ingredient is now also available in a convenient RTD format for everyday easy intake.

    Feel free to contact us via for more information on the possibilities Bonolive® has to offer.

    Further information can be found on:


    About Solabia – BioActor

    BioActor, a Solabia Nutrition company, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive formulations with clinical studies. The company focuses on the development of innovative bioactives that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

    For further information, see

    gut skin axis Bonolive

    How does your digestive system affect your skin health?

    The gut-skin axis: how does your digestive system affect your skin health?

    Maastricht, 29th February 2024

    The gut-skin axis defines the relationship between the gut microbiota and skin health. Factors such as diet, microbial diversity, and gut barrier integrity are pivotal in modulating this axis. Understanding this relationship offers avenues for holistic dermatological interventions targeting gut health and is the subject of this article.

    gut skin axis Bonolive

    What is the Gut microbiome?

    The gut microbiome refers to the community of microorganisms residing in the gastrointestinal tract (1). This intricate ecosystem plays a pivotal role in various physiological processes, from digestion and nutrient absorption to immune system regulation (2). Furthermore, the gut microbiome is integral to synthesizing vitamins, metabolizing drugs, and maintaining gut barrier function (3).


    Several factors can influence the composition and diversity of the gut microbiome. Diet, particularly the consumption of fiber-rich foods, can shape microbial populations (4). Additionally, antibiotics, stress, and lifestyle choices such as smoking can significantly impact microbial balance (5)



    What is the role of the skin for health?

    The skin, the body’s largest organ, serves as a protective barrier against external factors, regulating temperature, and facilitating sensory perception (6). It plays a crucial role in immune surveillance, defending against pathogens and environmental insults (7). The skin’s health is influenced by numerous factors, including genetics, age, sun exposure, and environmental pollutants (8).


    Common issues encompass a range of conditions, from acne and eczema to more severe disorders often influenced by both genetic predisposition and environmental triggers (9). Maintaining skin health requires a balanced approach addressing both intrinsic and extrinsic factors affecting this vital organ.


    What is the link between the gut and the skin?

    The gut-skin axis represents the relationship between gut health and skin conditions, suggesting that alterations in gut microbiota can influence dermatological health (10). This bidirectional communication system involves various mechanisms linking gut health to skin conditions (11). For example, increased gut permeability, or “leaky gut,” may lead to systemic inflammation, exacerbating skin inflammation characteristic of acne (12). Additionally, dysregulated gut flora can compromise immune tolerance, potentially contributing to allergic skin reactions seen in eczema (13).


    Understanding the gut-skin axis offers insights into approaches for managing skin conditions by targeting gut health. Modulating gut microbiota through dietary interventions or probiotics may offer promising therapeutic strategies for dermatological health.

    Factors influencing the gut-skin axis?

    The gut-skin axis is influenced by various factors, encompassing lifestyle, medication, and diet. Lifestyle choices, including stress levels and sleep patterns, can significantly impact gut microbiota composition, subsequently affecting skin health. Chronic stress, for instance, can disrupt gut microbial balance, contributing to systemic inflammation and exacerbating skin conditions like acne (14, 15).


    Dietary habits play a pivotal role in shaping the gut microbiome, with fiber-rich diets promoting microbial diversity and beneficial gut flora. Conversely, diets high in processed foods and sugars can foster dysbiosis, potentially aggravating skin conditions like acne and eczema (16).


    Understanding these influencing factors offers avenues for targeted interventions to optimize the gut-skin axis, emphasizing the interconnectedness of lifestyle, medication, and dietary choices in dermatological health.


    Which nutrients benefit skin health?

    Several nutrients play pivotal roles in promoting optimal skin health:

    Omega-3 fatty acids support skin hydration and combat inflammation, benefiting conditions like eczema (17).
    Vitamin E acts as an antioxidant, protecting skin cells from oxidative damage and promoting skin elasticity (18).
    Vitamin C aids collagen synthesis, essential for skin structure and wound healing (19).
    Zinc supports skin cell regeneration and immune function, contributing to overall skin vitality (20).
    Oleuropein, a compound primarily found in olive leaves, holds promise in lowering skin inflammation and supporting skin hydration due to its moisturizing and antimicrobial properties (21). Bonolive® is an olive leaf extract standardized for high levels of oleuropein.



    In summary, the gut-skin axis connects gut microbiota to skin health, influenced by factors like diet and medications. Nutrients like oleuropein, omega-3s, vitamin E, vitamin C and zinc promote skin health, emphasizing the importance of diet in dermatological well-being.

    Bonolive espana mira aqui

    WEBINAR: Women's Health with Bonolive® ES

    WEBINAR: Women’s Health ES

    With Bonolive®

    Are you interested in a women’s health ingredient backed-up by science? At this webinar, we will present Bonolive® and the benefits of adding it to your formulation. Find out more about the science behind Bonolive® its formulation possibilities. Dive into the world of women’s health with our exclusive webinar in Spanish . Watch on demand!


    Why watch?


    The awareness about women’s health and especially menopause support is growing. As consumer demand is increasing in this area, brands should be satisfying the need for science-based and clean-produced ingredients. At this webinar, we set the focus on Bonolive®, our premium women’s health ingredient. Deepen your knowledge about the science behind this olive leaf extract as well as the benefits it offers. Find out the opportunities of formulation and product formats available. 

    bonolive webinar speakers

    Presentation by Marit

    10 minutes

    EU Market Insights: Explore the latest trends, expected growth, and consumer preferences in the EU women’s health market, with a specific focus on Spain. 


    Presentation by Valeria

    10 minutes 

    The Science behind Bonolive®: Discover the clinical data behind Bonolive® and understand the advantages it has to offer for menopausal women.


    Presentation by Tony

    10 minutes

    Sales and Formulation possibilities of Bonolive®: Learn about the origin and benefits of formulating with Bonolive®.


    oleuropein skin health bonolive

    How can oleuropein improve skin health?

    How can oleuropein improve skin health?

    Maastricht, 16th January 2024

    Who doesn’t desire youthful looks and optimal skin health? Unfortunately, the aging process tends to impact our skin negatively. Wouldn’t it be great if we could slow down this natural process and improve skin health? This article delves into the beneficial impact of oleuropein on preserving skin health.

    oleuropein skin health bonolive

    Why is skin health important?

    The skin, our body’s largest organ, acts as the primary barrier between the external environment and our internal world. Beyond its role in protecting against pathogens, toxins, and physical injuries, maintaining skin health is crucial to reducing the risk of infections and diseases (1).


    Additionally, the skin plays a vital role in regulating body temperature and preventing dehydration, contributing significantly to the overall balance and well-being of the body through the process of homeostasis (2).


    How does aging affect skin health? 

    As we age, the importance of maintaining healthy skin becomes even more apparent. The skin undergoes changes, caused by a combination of genetic and environmental factors. Sun and wind exposure, air pollution, climate conditions, chemical exposure, stress, smoking and alcohol consumption contribute to alterations in the appearance and function of the skin (3).


    Primarily, visible signs of aging manifest as wrinkles and fine lines. Collagen breakdown and a reduction in elastin fibers result in decreased skin elasticity and firmness. Additionally, aging causes thinning of the skin. The upper layers, the epidermis and dermis, become less thick and lose density, increasing the risk of injury and making blood vessels more visible on the skin surface (4).


    Maintaining healthy skin becomes paramount to tackling the aging factors, ultimately improving the quality of life as one ages (5). For example, skin dryness and irritation are natural consequences of decreased oil production with age (6, 7). To remedy this situation, nutritional supplements containing omega-3, collagen or oleuropein are showing some promise. Therefore, supporting skin health from within is a trend, currently popular for investigation among the scientific community.


    What is oleuropein?

    Oleuropein, a natural polyphenol, is abundant in olives, olive leaves and olive oil, giving them a distinctive bitter taste, especially in extra virgin olive oil (8). It is renowned for its antioxidant and anti-inflammatory properties, making it a subject of interest in various studies focused on skin health (8, 9, 10). It holds promise to support the skin’s natural oil production and tackle dryness and irritation.

    oleuropein benefits skin

    The beneficial effect of oleuropein on skin health

    As the skin undergoes the natural aging process, one of the prominent challenges it faces is an escalation in oxidative stress within skin cells. Oxidative stress is characterized by an imbalance between free radicals and the body’s ability to neutralize them. Free radicals are highly reactive molecules that can damage cellular structures including proteins, lipids, and DNA, which contributes significantly to skin damage. By effectively neutralizing free radicals, oleuropein helps to reduce oxidative stress in skin cells and preserves the integrity of cellular structures and functions (9).


    Furthermore, aging is often accompanied by an increased tendency towards inflammation in skin cells, a phenomenon linked to the emergence of various skin conditions. Oleuropein is suggested to have anti-inflammatory properties. It targets the pathways involved in the inflammatory process, helping to reduce the overall inflammatory burden. By doing so, oleuropein not only addresses the symptoms but also acts preventatively and its anti-inflammatory ability emerges as a valuable asset in promoting overall skin wellness and resilience (9).


    How to use Oleuropein as a supplement? 

    Olive leaf extract comprises 25-40% oleuropein (11). Achieving the clinically studied dose of 100mg of oleuropein per day through regular diet alone poses a challenge. Consequently, oleuropein supplementation is a practical consideration. Taking a daily supplement can help you reach the recommended clinical dose and have positive results.

    Typical application formats include soft gels, capsules, tablets and powders. Oleuropein is stable and can be combined with collagen, magnesium, selenium and vitamins B, D, E & K.

    Oleuropein’s dual action as an antioxidant and anti-inflammatory agent positions it as a valuable component in skin care, offering protective measures against oxidative stress and inflammation associated with the aging process (12, 13, 14).

    An example of an olive leaf extract that is standardized for its high oleuropein levels is Bonolive®.

    Bonolive for your women's health product

    5 reasons to use Bonolive® in your women’s health product

    5 reasons to use Bonolive® in your women’s health product

    September 5th, 2023

    Bonolive® is an extract based on olive polyphenols that contains a high amount of oleuropein, a potent phytonutrient found primarily in olive trees. Numerous studies have demonstrated the beneficial properties of Bonolive®, including mitigation of potential risks associated with menopause. In this blog, we will explore some of the scientific evidence supporting the health benefits of olive polyphenols and why you should use it in your women’s health product.

    Bonolive for your women's health product

    Bonolive®: Mediterranean support for women’s health

    Bonolive® is a natural compound sourced from olive leaves. It’s standardized to contain high levels of olive polyphenols, specifically Oleuropein.

    Developed by BioActor, its primary aim is to support women’s health during the post-menopausal phase (1). This period often introduces various health challenges, such as decreased bone density, joint discomfort, and a heightened risk of cardiovascular problems.

    Numerous clinical studies consistently highlight the positive effects of supplementing with Bonolive® (1 , 2 , 3). These studies have revealed that Bonolive® plays a role in enhancing bone strength, reducing joint discomfort, balancing lipid profiles, and easing specific menopause-related symptoms.

    Consequently, it contributes to lowering the risk of developing conditions like osteoporosis (brittle bones) and heart issues as time progresses.

    Oleuropein: the hero compound of Bonolive®

    Olive oil plays a pivotal role in the Mediterranean diet (4). The primary polyphenols in olive oil are oleuropein and its metabolite hydroxytyrosol. These polyphenols have been extensively studied and recognized for their preventive benefits against various disorders.

    Researchers have unraveled their mechanisms, showing promise in reducing the risks of breast cancer, ovarian cancer, postmenopausal osteoporosis, and other health issues.

    Bonolive® is standardized to contain oleuropein. Because of this, Bonolive® is a perfect match for adding to dietary supplements and functional beverages made to support women’s health during menopause.

    5 reasons to use Bonolive® in your women’s health product

    1. Bonolive® improves bone health and reduces joint discomfort

    Bonolive® has demonstrated its positive influence on bone and joint health (1). An investigation centered on post-menopausal women with reduced bone mass unveiled a notable surge in a foundational protein that serves as the framework for generating new bone. Moreover, an improvement in bone mineral density was seen.

    In a recent six-month study involving 124 participants aged 55 and above, the efficacy of Bonolive® came to light. It brought relief to joint discomfort linked to activities like walking, bending, and knee movement (2).

    Consequently, a daily dosage of 250 mg of Bonolive® proves sufficient to deliver advantageous outcomes for both bone and joint well-being.

    2. Bonolive® reduces menopause-related symptoms

    BioActor undertook a consumer study aimed at assessing the benefits of Bonolive® among post-menopausal women. This investigation unveiled the favorable influence of Bonolive® on alleviating menopause-related symptoms in this demographic.

    The study focused on women who had already gone through menopause, aiming to see how Bonolive® affected their reported symptoms. For 28 days, participants took Bonolive® regularly. After just 14 days, they felt better in terms of bloating, anxiety, mood swings, energy levels, and skin health. This improvement continued even after the full 28 days of using Bonolive®.

    This reinforces the potential of Bonolive® in enhancing the well-being of post-menopausal women.

    3. Bonolive® has favorable effects on lipid control

    Clinical research has shown the favorable impacts of Bonolive® in managing the blood lipid profile among post-menopausal women (1). Notably, supplementation with 250mg of Bonolive® over a 12-month period led to significant improvements. Specifically, a significant reduction in LDL-cholesterol, total cholesterol, and triglycerides was observed.

    4. Bonolive® has a superior bioavailability

    Another study aimed to assess the bioavailability of Bonolive®. Interestingly, a more substantial increase in the levels of metabolites in the blood of post-menopausal women was observed compared to women who hadn’t gone through menopause yet. This suggests that post-menopausal women experienced higher absorption of Bonolive®.

    Additionally, the study revealed that Bonolive® possesses antioxidant effects, as evidenced by its ability to reduce levels of a substance called MDA, which is a marker of oxidative stress.

    5. Bonolive® is a sustainable solution

    Olive trees hold the distinction of being among the oldest cultivated trees globally. However, the surge in olive oil production has taken a toll on the environment (5).

    The primary waste generated during olive growth is the pruned leaves of the olive trees. Yet, these leaves contain valuable compounds of which oleuropein is one. This is why Bonolive® is made from freshly cut olive leaves, meaning it is a clean, sustainable and natural ingredient for a women’s health product.

    Bonolive®: A key ingredient for women’s health

    Studies have found that Bonolive® can help women stay healthy after menopause. Using Bonolive® as an olive polyphenol extract can bring big benefits to women’s health products. Bonolive® can be used in many different products and has lots of advantages. It’s a great ingredient to promote a healthier lifestyle and improve women’s well-being.

    Curious to read about the clinical studies on Bonolive® in more detail? Download our white paper below!

    From tree to health support uncovering the benefits of olives, olive leaf and olive oil

    From tree to health support: uncovering the benefits of olives, olive leaf and olive oil

    From tree to health: uncovering the benefits of olives, olive leaf and olive oil

    July 25th, 2023

    Delve into the health benefits of the Mediterranean diet, centering on olives and extra virgin olive oil. Uncover the positive effects of oleuropein, particularly for women during and after menopause, providing natural support for overall well-being.

    From tree to health support uncovering the benefits of olives, olive leaf and olive oil

    The Mediterranean diet has gained widespread recognition as one of the healthiest diets globally, known for its ability to prevent diseases like heart disease and cancer.

    Key components of this diet include olives and extra virgin olive oil (EVOO), which are celebrated for their health benefits.

    In this article, we will delve into the composition of olives and EVOO, exploring the various health benefits associated with their consumption. Moreover, we will focus on their potential advantages for women facing post-menopausal concerns, shedding light on the natural alternatives available to alleviate their symptoms.

    Olives and extra virgin olive oil: Pillars of Mediterranean health

    The Mediterranean diet revolves around plant-based foods, whole grains, nuts, herbs, and spices. It encourages moderate consumption of fish, seafood, and poultry, while red meat and sugar are consumed infrequently. The main source of added fat in this diet is EVOO, which stands out for its numerous health benefits (1).

    Composition of extra virgin olive oil

    EVOO is derived from freshly cold-pressed olives, the fruits of the olive tree (Olea europaea). This process ensures that the beneficial components of EVOO, known as biophenols, are preserved.

    The primary fatty acids in EVOO are monounsaturates, particularly oleic acid, which constitutes 55-80% of the total fatty acid content. The remaining portion consists of small amounts of saturated and polyunsaturated fatty acids.

    Beyond the fatty acids, EVOO contains various minor components such as antioxidants, including carotenoids, α-tocopherol, and phenol compounds. Among these phenols, the main ones found in EVOO are hydroxytyrosol, tyrosol, and oleuropein. Oleuropein, in particular, is present in olives, olive leaves, and olive oil, making oleuropein a key player in the health benefits associated with these products.

    Oleuropein: a compound from olives and olive leaves with outstanding health benefits

    Oleuropein, a compound with remarkable health benefits, has been extensively studied for its potential in preventing various disorders. As an antioxidant, it effectively combats harmful compounds in the body, reducing the risk of heart problems, cancer, osteoporosis, Alzheimer’s, and premenstrual syndrome, among others. Studies have demonstrated its ability to protect cells from oxidative damage, reducing the risk of chronic diseases and contributing to the prevention of inflammatory conditions (2, 3).

    Furthermore, the cardiovascular benefits of oleuropein are noteworthy, as it supports heart health by reducing LDL (“bad”) cholesterol levels and lowering blood pressure. These effects, in combination with its antioxidant properties, contribute to the prevention of cardiovascular diseases such as atherosclerosis.

    Interestingly, while oleuropein is present in olive oil and olives, you might be surprised to learn that olive leaves contain even higher levels of this beneficial compound. This makes olive leaves a great source for obtaining oleuropein and reaping its healthful advantages (4).

    An example of an olive leaf extract that has high levels of oleuropein is Bonolive®.

    Women’s health: how can it benefit from olives?

    Postmenopausal women often experience symptoms such as fatigue, anxiety, and mood swings. The global population of postmenopausal women has grown significantly, leading to increased research on natural alternatives to alleviate these symptoms (5).

    Oleuropein’s ability to lower blood pressure may be beneficial for women with hypertension during menopause. High blood pressure is a common concern during this stage of life, and the consumption of EVOO as part of the Mediterranean diet could help manage this condition naturally (6).

    Oleuropein’s antioxidant properties are also relevant to women’s health. Oxidative stress is a contributing factor to the development of various diseases, and antioxidants like oleuropein help counteract this stress, promoting overall well-being.

    Recent studies have also shown that oleuropein has positive effects on bone health, which further enhances its impact on women’s health, especially during and after menopause.

    Osteoporosis, a condition characterized by reduced bone density and an increased risk of fractures, is a significant concern for postmenopausal women due to hormonal changes and declining estrogen levels. The anti-inflammatory properties of oleuropein play a crucial role in reducing bone loss and inflammation, helping to maintain bone strength and integrity.

    By including the Mediterranean diet with its oleuropein-rich olives and EVOO, women can potentially safeguard their bone health and mitigate the risks associated with osteoporosis. This contributes to an overall improvement in their well-being during the post-menopausal stage.

    Oleuropein and women’s health: the benefits of olives and olive leaf

    The Mediterranean diet, which includes olives and extra virgin olive oil, offers many health benefits, thanks to oleuropein: a compound that helps prevent diseases and promotes overall well-being, especially in women post-menopause.

    For those who may have limited olives or olive oil in their regular diet, supplements containing high levels of oleuropein might be beneficial. Bonolive®, an ingredient by BioActor, is high in oleuropein content and has been extensively studied.

    To read more about these studies, download our white paper below.


    Simple ways to boost your cardiovascular health

    Simple ways to boost your cardiovascular health

    May 10th, 2023

    Cardiovascular health refers to the health of the cardiovascular system. Its definition is based on all the behaviors and health factors that, when optimal, are associated with better cardiovascular disease-free survival and quality of life. Choosing a healthy diet, being more active, and maintaining normal blood lipid and glucose levels are some of the strategies that help to maintain great cardiovascular health throughout our lives.


    How to define cardiovascular health?

    The American Heart Association has provided a number of metric definitions that can be used to classify poor, intermediate, or ideal cardiovascular health. These include diet, physical activity, smoking, sleep, weight, blood and glucose levels, and blood pressure.

    Pursuing a healthier lifestyle from a young age is a great strategy for maintaining ideal cardiovascular health throughout our lives. This will result in a lower risk of developing cardiovascular diseases such as hypertension, strokes, atherosclerosis, peripheral artery disease, and vein diseases (1).
    In this article, we will dive into the 7 ways to improve your cardiovascular health!

    Healthy eating behaviors

    Creating a healthy eating pattern represents an easy way to improve your cardiovascular health. This means preferring certain foods such as vegetables, fruits, whole grains, plant-based proteins, fish and limiting sweetened drinks, alcohol, full-fat dairy products, and highly processed foods.

    Avoiding trans-fat and partially hydrogenated oils that are contained in many commercial baked goods represents another good and easy strategy to improve your eating habits (1).

    Polyphenols derived from olive leaves also have many beneficial effects and represent a promising, natural ingredient for supporting cardiovascular health (2).

    Giving up smoking

    Smoking is deleterious for your circulatory system as it increases the risk of stroke in both men and women. Cigarettes, e-cigarettes, and tobacco products contain many toxic chemicals, as do their smoke, and liquids. Several beneficial changes occur after quitting smoking and within one year after quitting, your risk of heart disease goes down with 50% (1).

    Physical activity

    Regular exercise and physical activity are associated with remarkable health benefits. Adults should do at least 150 minutes of moderate-intensity aerobic activity a week or 75 minutes of vigorous aerobic activity or a combination of both, throughout the week. Parking further away from your work place or taking the stairs instead of the elevator contributes to physical activity levels and improves health outcomes (1).

    Sleep quality

    Sleep plays a crucial role for overall health and well-being. Short sleep duration or poor sleep quality is associated with high blood pressure, elevated cholesterol levels, and atherosclerosis. These conditions can be prevented by aiming for an average of 7-9 hours of quality sleep a day (1).

    Body weight management

    Maintaining a healthy weight, defined as a body mass index between 18.5 and 24.9 for adults, can help reduce the risk of many heart problems such as cardiovascular disease, stroke, and high blood pressure.
    A few strategies that can help to manage body weight include choosing a healthy diet, increasing physical activity levels, limiting alcohol, avoiding stress, and improving your sleep quality (1).

    Stable blood lipid and glucose levels

    Cholesterol is a fat-like substance that your body needs, in the right amounts, for good health. Unhealthy levels of cholesterol can lead to a higher risk of cardiovascular disease, such as heart disease and stroke. Checking your cholesterol levels regularly can help you understand whether you have normal blood lipid levels.

    Over time, high blood glucose levels can damage your health too. Blood glucose levels rise because of the glucose that enters the bloodstream and insulin, a hormone that helps the cells take up the glucose they can use for energy production.

    A healthy diet that includes vegetables, fruits, whole grains, beans, legumes, nuts, plant-based proteins, and lean animal proteins, may help you manage cholesterol and glucose levels. Other strategies include being more active, quitting smoking, and maintaining a healthy weight (3).

    Blood pressure control

    Blood pressure is defined as the pressure of your blood on the walls of the arteries as your heart pumps it throughout your body. When your blood pressure is permanently higher than normal, the risk of heart attacks and strokes increases.

    There are no signs or symptoms of high blood pressure, which means it is crucial to have regular check-ups to measure it. Simple changes to your lifestyle, such as eating healthy and being more active can help manage your blood pressure over time (4).

    How to improve your cardiovascular health?

    To summarize, choosing a healthy diet, quitting smoking, being more active, improving sleep health, maintaining normal blood lipid, and glucose levels, and managing your blood pressure are great strategies to lower the risk of developing cardiovascular disease thus, improving your cardiovascular health.