new strategy to loose weight

Are there any new strategies for weight management?

Are there any new strategies for weight management?

Maastricht, 10th May, 2024

For many different reasons, almost everyone has been concerned about their weight. Nowadays, we all want to find new effective approaches to control our weight in a healthy, sustainable, and easy manner. Could arabinoxylans be the answer we have been looking for?

new strategy to loose weight

How relevant is weight management?

 

Weight is a common worry for a large part of society. Whether it is driven by aesthetic preferences or health considerations, almost everyone has thought about losing some weight. Body image and the beauty standard that is established in the Western culture plays an important role and pressures many to lose weight (1).  

However, there is a growing number of people interested in improving their health and quality of life: not only they want to be healthy, but they also want to feel healthy (2). As a result, there is a growing interest in holistic solutions that people can seamlessly integrate into their lifestyle without uncomfortable restrictions .

 

How to lose weight? 

 

While it’s true that weight loss ultimately comes down to burning more calories than you consume, many traditional diets and exercise programs are designed as short-term solutions that are difficult to sustain in the long run. However, new alternatives are emerging. For example: 

  • Intermittent fasting is an eating pattern where the individual restricts all the calories that has to eat in a day to a few hours of eat and fasts for the rest of the day (3). Although some studies have shown this helps control weight, evidence is not strong enough (4). This pattern has to be adapted in the long term for it to work, but it is not manageable to many people.  

 

  • A high protein diet can help with weight management as protein digestion delays the hunger sensation. But for a diet to be consider high in protein (5), about 1.2 g/kg of body weight have to be consumed. In a normal diet, people consume less than 0.8 g/kg of body weight a day. Increasing the protein intake and sustaining it over time can be tricky for some people (6). In addition, people with certain health concerns such as kidney issues are not recommended to follow these diets.  

A new emerging strategy for weight management 

 

Arabinoxylans are dietary fibres found in the cell walls of plants, such as grains like wheat (7). As many dietary fibres, arabinoxylans are polysaccharides that help with gut health. They act as prebiotics, food components that are not absorbed by the intestine, but rather support digestion and the health of the gut microbiome. 

 

Research shows that arabinoxylans have the ability to regulate the postprandial (after-meal) glucose response (8). By controlling spikes in blood glucose levels, they can help regulate appetite. A more controlled glucose response is associated with a lower appetite, which usually translates in a decrease in calorie intake (9), an essential factor for weight loss and maintenance.  

 

What is the clinical evidence – can arabonoxylans help in weight management? 

 

A recent study (10, 11) with such arabinoxylans – Naxus® and inulin suggests that arabinoxylans could be a great ally for weight loss management. Participants who consumed arabinoxylans had a significant decrease in their calorie consumption, meanwhile their self-reported appetite did not decrease. 

 

It is believed that the increase in beneficial bacteria, such as Bifidobacterium and Propionibacterium, led to an increase in production of short-chain fatty acids (SCAFs). Additionally, there was also an increase in acetate, which can have an effect on appetite independently, explaining the study’s results.  

 

Including arabinoxylans in strategies for weight loss could be more approachable for a certain type of consumers that struggle to change their eating habits. This approach would not require a complete change of their routine, adding products enriched with arabinoxylans to their diet could make a significant difference.  

 

Conclusion  

 

Whether it is for health concerns or aesthetic reasons, weight management is in the mind of many people. Our society wants to be and to feel healthy. Weight loss can be difficult to many people and most strategies are not sustainable in the long term. Adding arabinoxylans to the diet has proven to be an innovative and approachable solution that can be adopted by many people.  


adult nutrition formulas

What are adult nutrition formulas?

What are adult nutrition formulas? Types and health goals 

Maastricht, 26th April, 2024

Adult nutrition formulas represent a category of functional food products that is gaining growing popularity these days. Though such powder products were originally designed as meal replacements for weight management, adult nutrition formulas have found new relevance among adults to reach a broad range of health and nutritional goals due to their convenience, versatility, and nutritional value.

adult nutrition formulas

What are adult nutrition formulas?

These products encompass a variety of supplemental foods aimed at providing consumers with a complete and nutritious meal. These formulas typically come in ready-to-drink shakes or plant- or milk-based powders that can easily be solubilised in water or other liquids [1].

While milk-based powders have traditionally dominated the market, plant-based formulas are gaining traction and are expected to gain market share.

Typically, these formulas are fortified with functional ingredients such as vitamins, minerals, fibers, and proteins to address specific consumer health goals, such as weight management, sports performance enhancement, or diabetes control [2]. Due to the popularity of these customisable supplements, new formulas are emerging rapidly.

Even though these products have targeted health aims, many of these formulas offer a comprehensive nutritional profile suitable for any individual seeking a convenient and balanced meal option. The powdered form or the pasteurised shakes grants them an extended shelf life and versatility, making them ideal for on-the-go consumption. A typical example of the latter is breakfast drinks with prebiotic fiber like arabinoxylans which are both healthy and keep you satiated for a couple of hours.

These advantageous properties make adult nutrition formulas suitable for various lifestyles, including those with busy schedules or specific dietary requirements.

Advantageous attributes of adult nutrition formulas

Adult nutrition formulas offer numerous advantages, making them highly appropriate for various lifestyles. Below are additional beneficial attributes of adult nutrition formulas:

  • No need for cold storage: powders and pasteurised shakes are very stable and resistant to spoilage, mould, or other factors affecting shelf life. This eliminates the need for cold storage, enhancing convenience for consumers.
  • High solubility and dispersibility: the products have strong soluble properties, making them highly suitable for mixing with nutrients such as plant extracts and speciality fibers such as arabinoxylans. Their ability to dissolve and disperse easily in liquids ensures a smooth and uniform texture.
  • Low/no sugar content: powders or ready-to-drink shakes often contain little sugar, making them a healthy food choice for the average consumer.
  • Low allergen: many adult nutrition formulas are free of allergens such as gluten, dairy, soy, and nuts. This makes them suitable for individuals with food sensitivities or allergies, broadening their accessibility.
  • All natural: depending on the brand, adult nutrition formulas are crafted with all-natural ingredients, free from artificial additives or preservatives.
  • Nutrient-dense: adult nutrition formulas are packed with essential nutrients per serving, providing a convenient way to meet daily nutritional needs.
  • Tailored health attributes: due to their customizable properties, adult nutrition formulas can be adjusted to any health goal.
  • Carrier for health claims: given the pack size, there is ample space both in the powder and – literally – on the label to use ingredients with health claims.
  • Part of daily ritual: since adult nutrition formulas offer the possibility of a completely nutritious and healthy serving, consumers will be encouraged to include these products in their daily routines and rituals.

Next generation: benefits beyond general nutritional support

The emerging trend of adult nutrition formulas reflects a growing demand for functional nutrition beyond basic dietary needs. While initially designed to address weight management or ‘special medical purposes’ (medical nutrition drinks such as Boost and Ensure), adult nutrition formulas have evolved to incorporate functional ingredients tailored to meet diverse health goals, particularly among middle-aged and older consumers.

Young consumers are also drawn to this part of the functional food market, particularly breakfast drinks, which offer a complete nutrition profile and sustained satiation throughout the morning. The next step in breakfast drinks is to add speciality prebiotic fiber, such as arabinoxylans, which carries a fiber claim, a health claim and contributes to a sense of fullness thanks to its viscous properties. Health-conscious individuals integrate these breakfast drinks into their dietary routines as a mindful choice.

In addition, this on-the-go product can further be enhanced to support workout or endurance sports. For example, breakfast drinks enriched with electrolytes, caffeine, branched-chain amino acids or creatine.

Health benefits of adult nutrition formulas

The formulas are designed to serve various health goals, with formulations tailored to meet specific nutrition needs. The powders were originally designed to replace complete meals. However,  these formulas have evolved to incorporate targeted health benefits, particularly for middle-aged and older consumers. Below, common health benefits including corresponding ingredients are listed:

  • Weight Management: high protein and prebiotic speciality fiber (such as arabinoxylans), variety of vitamins and minerals, and low carbohydrate and sugar content. Weight management formulas have evolved from complete meal replacement products to targeted nutrition for reducing calorie intake or satiation.
  • Immune Support: rich protein content, variety of vitamins and minerals, and speciality fibres (such as beta-glucans and arabinoxylans [3]). Examples of immune-supporting formulas are Ensure Nutrivigor, and the new Actimel Plus in larger multi-serving bottles.
  • General Well-being: various vegetable and fruit extracts, fibres, protein and omega-3 fatty acids. These formulas are ideal for breakfast drinks, such as Weetabix on the go, UP&GO Breakfast Shake, and Naked Juice Core.
  • Sports Enhancement: classical formulas are high in protein and branched-chain amino acids (BCAA). More recent launches combine macronutrients with functional micronutrients such as citrus flavonoids, creatine, or beta-alanine. Examples of such products are ESN Perfect Pre and Shape Code Protein Shake.
  • Diabetes Control: high in soy and whey proteins, fibre (such as arabinoxylans [4]), and MCTs. Product examples are BOOST Glucose Control and FontActiv DiaBest.
  • Bone Health; high calcium, protein, collagen, magnesium, vitamin D, C and zinc. Popular product examples are ANLENE Gold 5X and Nature’s Way BoneHealth.
  • Digestive Health; prebiotic fibres (such as arabinoxylans [5]), probiotics, and omega-3 fatty acids. Examples of consumer products include MegaMucosa or Upfront Prebiotica.

The regulation of adult nutrition formulas

The regulatory status of adult nutrition formulas can vary depending on their intended use and formulation. In general, these products are classified as either foods, dietary supplements, or food for special medical purposes (FSMP), each subject to different regulatory frameworks.

Regulated as foods or supplements?

If the adult nutrition formula is intended to be consumed as a regular part of the diet, and does not make specific claims about treating or preventing diseases, it is typically regulated as a conventional food. In this case, it must comply with food labelling and safety regulations set by the relevant authorities, such as the FDA in the United States, or the EFSA in the European Union.

In the EU, supplements are regulated as foods and must therefore adhere to the food directives set by the EU. In the United States, however, dietary supplements must adhere to regulations set by the Dietary Supplement Health and Education Act (DSHEA).

Many Asian countries will consider adult nutrition formulas as food products, which often means that no prior registration is required, but also that no health claims are allowed. This is notably the case in Malaysia, China and Korea.

 

Regulated as medical foods

Foods for special medical purposes (FSMP) include oral nutritional supplements and enteral tube feeding. The definition of this varies across regions of the world.

In the EU, these foods should adhere to specific legislation and are intended for consumers whose nutritional requirements cannot be met by normal foods. These products require pre-market authorizations before they can be placed on the market. There must be scientific evidence supporting the safety, quality, and efficacy of the product. Interestingly, if such scientific evidence is available, medical claims are allowed, without having to go through the EFSA health claim route.

In the US, medical foods are regulated under the Orphan Drug Act which provides incentives for the development of products for rare diseases or conditions. These products must adhere to specific criteria, requiring that the medical food provides a medically essential nutritional component that cannot be obtained through a normal diet. Moreover, medical foods need to be taken under the supervision of a medical practitioner.

Growing popularity of adult nutrition formulas

The growing popularity of adult nutrition formulas is evidenced by the significant market growth. Initially developed for infants to ensure adequate intake of essential nutrients, these formulas attracted older populations seeking convenient, nutritionally complete meal options [6].

To illustrate, the global adult milk powder market size was $7150.54 million in 2022 and the market is projected to double by 2031, exhibiting a compound annual growth rate (CAGR) of 9.09% during the forecast period [7].

Particularly in the Asia-Pacific region, demand is on the rise, attributed to factors such as ageing populations and concerns for bone and muscle health. This is, for example, shown in China, where a declining birth rate has led to increased interest in adult nutrition formulas [8,9].

This emerging trend in adult nutrition formulas holds great promise for the future development of these functional food products. The high demand for nutritious food, that is customisable to consumer needs offers great potential and promising plans for the future. For instance, breakfast beverages fortified with arabinoxylan fibres exemplify this potential.


naxus in gut health formula

4 reasons to include Naxus® in your gut health formulation

4 reasons to include Naxus® in your gut health formulation

Maastricht, 15th March, 2024

Arabinoxylans are essential prebiotics that exert beneficial effects on human health, particularly gut health. The relationship between diet and gut health has gained popularity in the last decades, with promising research emerging at an increasingly rapid pace. For product developers, it can be challenging to decide which ingredients to include in their gut formulation. In this article, you will discover 4 compelling reasons to include Naxus® in your gut health formulation.

What is Naxus®?

Naxus® is a patent-protected, prebiotic arabinoxylan extract sourced from the wheat endosperm. It can boost the immune system and improve gut health.

Solabia-BioActor developed Naxus® and conducted extensive research in collaboration with Maastricht University, Wageningen University & Research, Institute Pasteur and more, demonstrating its positive effects in numerous studies.

Clinical research in diverse populations shows that Naxus® promotes gut health by improving intestinal barrier function, increasing beneficial micro-organisms (e.g., Bifidobacteria and Bacteroides), improving the short-chain fatty acid (SCFA) profile and inducing cytokine and chemokine production (1, 2, 3).

Naxus® exerts its beneficial effects at doses starting at 1 g. Click below to see the scientific evidence.

4 reasons why Naxus® is a great addition to gut health formulations

If you are considering including Naxus® in your formulation for gut health, you should consider the following aspects:

 

1. Naxus® improves SCFA profile and strengthens the gut barrier

Health-promoting micro-organisms are present in the gut and help to protect the gut wall from pathogens and bad bacteria. Studies have demonstrated that Naxus® supports the growth of beneficial microbiota (1). Consequently, these microbiota produce advantageous SCFAs like propionate and butyrate.

SCFA production is related to a variety of positive health effects. To illustrate, these metabolites reduce the risk of developing inflammation and promote psychological and physical health. Moreover, they regulate the host immune system and improve metabolic health (4, 5).

 

2. Naxus® supports the immune system 

Naxus® has proven immunomodulatory properties by enhancing gut barrier integrity and improving the adaptive and innate immune system.

Research indicates that Naxus® improves multiple gut barrier parameters such as reduced intestinal permeability, increased goblet cell number, and higher intestinal immunoglobin A concentrations (6).

Additionally, Naxus® has been shown to increase vaccination efficacy against influence resulting in fewer adverse events, fewer respiratory tract infections, and improved seroprotection rates (7).

Moreover, Naxus® improves the innate immune system, leading to an increased immune system vigilance (2, 3).

 

3. Naxus® is slowly fermentable without bloating

Naxus® is composed of long and complex carbohydrate molecules, that ferment slowly and gradually (8). Therefore, Naxus® has an advantage over other fibres like inulin, because it does not cause intestinal complaints such as bloating and gas formation in the gut.

 

4. Naxus® can be used in many formulation types

Arabinoxylans, with their favourable physicochemical properties, have been successfully incorporated into numerous food products. Naxus® is wheat-derived and gluten-free and is therefore suitable for various formulations.

Naxus® has an emulsifying capacity and influences the viscosity of multiple foods. Its effects have been tested in products such as pasta, bread, beer, cakes, and cookies. For example, in the bread-making processes, arabinoxylans positively affect dough consistency, loaf volumes, crumb structure, and bread staling.

These beneficial technological characteristics prove the potential to include Naxus® in any gut health formulation.

 

Naxus®, the key ingredient for your gut health formulation

Naxus® contributes to your gut health by improving the microbiome, protecting the intestinal gut barrier, and supporting the immune system. It is a patent-protected product that bears an EFSA claim for reduction of post-prandial glycemic response and can be incorporated into multiple food products due to its beneficial properties.

Its innovative and science-based nature makes it a valuable addition to optimise your gut health formulation!


benefits of prebiotics

What are prebiotics? Types and health benefits

What are prebiotics? Types and health benefits

Last updated: February 22nd, 2024

February 7th, 2022

Prebiotics are a big topic in nutrition these days. As with probiotics, their relationship with human health has gathered a lot of interest in recent years. Prebiotics are compounds derived from non-digestible carbohydrates that confer health benefits to the host by selectively stimulating the growth of intestinal bacteria.

benefits of prebiotics

What are prebiotics?

Prebiotics are non-digestible food ingredients that confer health benefits to the host by selectively stimulating the growth and/or activity of a limited number of our intestinal bacteria [1].

Fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS), and trans-galacto-oligosaccharides (TOS) are the most common prebiotics.

Fermentation of prebiotics by gut microbiota produces short-chain fatty acids (SCFAs), such as lactate, butyrate, and propionate. These SCFAs have multiple beneficial effects on the body and gut health, as SCFAs are small enough to enter blood circulation through gut cells.

The difference between probiotics and prebiotics is that, while probiotics are beneficial bacteria, prebiotics are the food for these bacteria. Both are important for human health, but they have different roles. Probiotics are live bacteria and prebiotics are compounds derived from non-digestible carbohydrates such as fibre.

What are the different types of prebiotics?

There are various types of prebiotics. These include:

• Fructans such as inulin and fructo-oligosaccharides (FOS) can promote directly or indirectly several bacterial species.

• Galacto-oligosaccharides (GOS) can greatly stimulate Bifidobacteria and Lactobacilli, as well as Enterobacteria, Bacteroidetes and Firmicutes to a lesser extent [2].

• Hemicellulose-derived oligosaccharides such as arabinoxylans. Arabinoxylans could produce a strong prebiotic activity, in particular bifidogenic.

• Starch and glucose-derived oligosaccharides, a type of starch resistant to small intestine digestion, can stimulate the production of butyrate, a short-chain fatty acid (SCFA) [3]. Polydextrose, a glucose-derived oligosaccharide, can also stimulate Bifidobacteria [4].

• Pectic oligosaccharides (POS): some oligosaccharides come from a polysaccharide called pectin. This type of oligosaccharide is called pectic oligosaccharide (POS).

• Non-carbohydrate oligosaccharides: although carbohydrates are more likely to meet the criteria to be considered prebiotics, there are other compounds not classified as carbohydrates, but that can be classified as prebiotics, such as some flavanols [5].

Did you know you can combine prebiotics and probiotics to create synbiotic dietary supplements? Read more about that here!

What are the health benefits of prebiotics?

Research shows that prebiotics have a beneficial effect on gut health, which is directly linked to overall well-being. In addition, prebiotics exert their positive effects via the following pathways:

• Microbiota support: prebiotics provide energy sources to gut microbiota. This way, they are able to modulate the function and composition of these microorganisms [6].

• Immune system modulation: SCFAs have multiple benefits for the immune system, such as increasing antibody responses towards pathogens [7].

• Colorectal cancer risk reduction: fermentation products of probiotics, such as butyrate, have possible protective effects against the risk of colorectal cancer [8].

• Infants gastrointestinal disorder prevention: prebiotics can redice the risk of development of necrotizing enterocolitis in preterm infants [9].

• Skin irritation conditions: the risk of development and the severity of atopic dermatitis [10, 11] could decrease after prebiotic intake.

• Cardiovascular diseases (CVD) risk reduction due to the potential of prebiotics to reduce inflammatory markers and improve lipid profile [7].

How can I add prebiotics to my diet?

Prebiotics play an important role in human health, so it is important to consume them. They can be found in foods that are high in fibre, such as vegetables, fruits, legumes and whole-grain products. Foods that are high in prebiotic fibre include:

• Wheat
• Soybeans
• Oats
• Bananas
• Tomatoes
• Berries
• Asparagus
• Garlic
• Leeks
• Onions
• Chicory

Another option to increase prebiotic intake is supplements, purchased in health food stores and online. They are usually available in capsule form, in powder blends or even in bars.

Prebiotics are generally considered safe. They can have some minor side effects, such as diarrhea, bloating and flatulence. However, prebiotics’ chain length is the main parameter related to the development of these side effects.

Prebiotics with a shorter chain length have more side effects because they ferment earlier and more rapidly, while longer chain prebiotics – such as arabinoxylans from wheat– ferment slowier.


BIOACTOR and PIXIENCE start collaboration on validation of skin imaging technology in nutrition studies

BIOACTOR and PIXIENCE start collaboration on validation of skin imaging technology in nutrition studies

BIOACTOR and PIXIENCE start collaboration on validation of skin imaging technology in nutrition studies

MAASTRICHT/TOULOUSE, August 22nd, 2023

Press release
BIOACTOR and PIXIENCE announce the start of a collaboration to test and validate an innovative skin imaging and testing technology in the context of a clinical study with a nutritional bioactive.

BIOACTOR and PIXIENCE start collaboration on validation of skin imaging technology in nutrition studies

BIOACTOR and PIXIENCE announce the start of a collaboration to test and validate an innovative skin imaging and testing technology in the context of a clinical study with a nutritional bioactive.

PIXIENCE has developed an innovative skin image capturing device (C-Cube) and image analysis software (QuickScale) for the evaluation of several skin parameters, including the evaluation of 3D images.

BIOACTOR has expertise in the clinical validation of health effects of natural compounds and is now setting-up a clinical testing platform around nutritional actives for skin health.

PIXIENCE is developing the C-Cube Clinical Edition and BIOACTOR will carry-out beta testing of the Clinical Edition in a new clinical study on an oral nutritional product. PIXIENCE will provide technical assistance to BIOACTOR for the skin image analysis in this new clinical study.

Sebastien Mangeruca, CEO of PIXIENCE comments:
We have initially developed our C-Cube and QuickScale suite of technologies for the evaluation of topical cosmetic products. BIOACTOR’s experience in running clinical studies for nutrition and its active programme around nutrition and skin health, makes them an ideal partner for testing and validating of our C-Cube Clinical Edition for nutrition studies”.

Hans van der Saag, CEO of BIOACTOR comments:
BIOACTOR is delighted to work with PIXIENCE, as PIXIENCE has developed a best in class skin imaging and analysis technology that will allow us to further improve our skin health for nutrition platform. BIOACTOR wants to bring clinically backed innovation to the nutrition industry. BIOACTOR tests all of its products in scientifically robust human intervention studies, working with partners like PIXIENCE and the Department of Health and Nutrition of Maastricht University.

About BIOACTOR

BIOACTOR, based in Maastricht, Netherlands, is a product development company that develops and supplies proprietary bioactive formulations to the health and sports nutrition industry. All BIOACTOR’s products are clinically tested, doping-free and from natural origin. The main focus areas are: gut microbiome, brain health, energy & vitality and skin health.

For more information, please contact:

BioActor
Hans van der Saag, CEO
Email: hans.vandersaag@bioactor.com

Pixience
Sébastien Mangeruca, CEO
Email: Sebastien.mangeruca@pixience.com
www.pixience.com


New publication Naxus® consumption supports weight management through reduction of actual calorie intake in an ad libitum meal

New publication: Naxus® consumption supports weight management through reduction of actual calorie intake in an ad libitum meal

New publication: Naxus® consumption supports weight management through reduction of actual calorie intake in an ad libitum meal

Maastricht, The Netherlands, 27th July 2023

Press release
This randomized controlled crossover study showed Naxus®’ potential for appetite control and weight management. In a 21-day trial with healthy adult males, it was reported that consumption of a blend of Naxus® and inulin showed significantly lower calorie intake in an ad libitum meal (838 kcal vs. 1023 kcal) while reporting no changes in appetite. The blend was also shown to increase faecal SCFA concentrations. These results highlight Naxus®’s potential to transform appetite regulation.

New publication Naxus® consumption supports weight management through reduction of actual calorie intake in an ad libitum meal

Naxus®: clinically validated and developed by BioActor

Naxus® is a clinically validated arabinoxylan extract developed by BioActor, derived from wheat endosperm. It has been extensively studied and shown to have beneficial effects on microbiota composition, glycaemic control, and immune system function.

Naxus® promotes the growth of beneficial bacteria, production of Short Chain Fatty Acids (SCFA) and improves glycaemic control by inducing GPR43 signaling which leads to reduced glucose peaks and improved insulin sensitivity (1, 2). It also strengthens the immune system through various mechanisms (3, 4, 5). It is a well-researched ingredient with significant potential for enhancing overall health and well-being.

The study: Chronic consumption of a blend of inulin and Naxus® reduces energy intake in an ad libitum meal but does not influence perceptions of appetite and satiety

Introduction

Two dominant bacterial strains account for more than 90% of the total bacterial gut community: Bacteroidetes and Firmicutes (6). They are widely believed to have important effects on the maintenance of normal intestinal homeostasis. Stressors associated with modern lifestyles (e.g. low fibre diet) can chronically change the bacterial gut composition and lead to the increase of more virulent microbes that adversely affect the health of the host.

Gut microbiota break down fibre from our diet and produce SCFAs such as propionate, acetate, and butyrate as a result. These metabolites lead to activation of a pathway that is linked to appetite reduction.

Specifically, propionate and acetate bind to a receptor called GPR43, which is found in cells lining our stomach and intestines (7). Activation of GPR43 leads to a cascade of signals eventually triggering the production of GLP-1 and PYY, two hormones involved in inducing satiety.

Naxus has previously been shown to increase propionate levels and GLP-1 production (8). In this current study, it was investigated whether a blend of Naxus® and inulin would positively affect satiety and energy intake.

Methods

In this cross-over study, the authors investigated the effect of inulin + Naxus® on 20 healthy adult males aged between 22 and 55 with no evidence of metabolic or cardiovascular disease.

Each participant took part in both control and intervention conditions, each lasting 21 days. Both the treatment and control groups had to drink two sachets of dry powder dissolved in 150 ml of water daily for 21 days. Therefore, the participants consumed the intervention (or the control) sachet for 21 days following a 14-day period washout, and afterwards the control (or the intervention) sachet for an additional 21 days. The intervention sachet contained 2 g of Naxus® and 2 g inulin, whereas the control sachet contained 4 g of maltodextrin.

After a 14-day wash-out period, participants switched to the other drink for another 21 days. The study comprised 4 visits to assess the participants’ perceived satiety and appetite, the energy intake in an ad libitum meal, faecal SCFA concentration, and the faecal microbiota composition.

Results

Appetite control and calorie intake

The study found that the mean energy intake in an ad libitum meal were significantly lower during the treatment period (838 kcal) compared to the control period (1023 kcal) (p<0.05).

Surprisingly, no changes in self-reported appetite were found. This difference between self-reported appetite and actual calorie intake is common in studies involving prebiotics, which is why measuring actual food intake provides a more objective measure.

Naxus and Inulin results on kcal intake

Microbial composition

Significant changes in the microbial composition of fecal samples were noted, showing noteworthy increases in the abundance of Bifidobacteria (p = 0.035), Lactobacilli (p = 0.061), and Propionibacteria (p = 0.02).

Short-chain fatty acids

Moreover, these changes were accompanied by an elevation in the concentration of short-chain fatty acids (SCFAs), which are known to be associated with gut health. More specifically, an increase of acetate in the faeces sample was reported after 21 days (p=0.02). Acetate has the ability to independently influence appetite, which may explain why the participants consumed fewer calories during a single meal.

The hypothesized increase in propionate levels in the faeces sample was only minimal and not statistically significant (p=0.07). However, it is important to note that faecal propionate concentration alone does not reflect the absorption by the body. Additionally, the signals of propionate in the liver and bloodstream, which were not measured in this study, could potentially have a more significant impact on appetite regulation.

Triple effect

Overall, the results show that the chronic consumption of a blend of inulin and Naxus® leads to a reduction in energy intake, an increase in faecal SCFA concentrations, and an increase in beneficial gut bacteria.

Conclusion

This research indicates that a combination of inulin and Naxus® has positive effects on gut health and confirms existing data that Naxus® positively influences appetite control.

This publication also emphasizes the importance of new studies focusing on the effect of Naxus® on enhancing and tailoring nutritional products to promote satiety and help weight management.

Click here to read the complete publication

About BioActor

BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact via info@bioactor.com for more information on the possibilities Naxus® has to offer. Further information can also be found on: www.naxus.nl or www.bioactor.com/products/naxus.


The importance of clinical research: An interview with BioActor's in-house scientists

The importance of clinical research: An interview with BioActor’s in-house scientists

Maastricht, The Netherlands, 29th June 2023

Interview
In the world of clinical research and scientific exploration, BioActor stands out as a leading company dedicated to the development of health ingredients. At the forefront of BioActor’s research and development (R&D) efforts are Sanne Ahles and Maria Imperatrice, two certified clinical research scientists who play vital roles in the BioActor’s R&D initiatives. In this interview, Sanne and Maria provide insights into their responsibilities, experiences, and the challenges they face in their pursuit of scientific advancement.

Could you introduce yourself and your role within BioActor?

Sanne: My name is Sanne Ahles and I am a clinical research scientist at BioActor. In addition, I am a PhD candidate at the Department of Nutrition and Movement Sciences at Maastricht University. I obtained my master’s degree in biomedical sciences after my internship at BioActor, after which I started working as a researcher.

Within BioActor, I am responsible for the research regarding our product Brainberry®, mainly focused on cognitive performance and vascular function. Over the years, I have designed, performed, analyzed, and reported various clinical studies, as well as written a systematic literature review.

Maria: My name is Maria Imperatrice and I also work as a clinical research scientist at BioActor. My research focus is Healthy Ageing and I’m currently performing two studies, Actiful2 and FEMMED, on two of our ingredients (Actiful® and Bonolive®) to evaluate their effect on exercise performance and postmenopausal symptoms, respectively.

I obtained my Bachelor Degree in Biology and my Master in Human Nutrition at the University “Federico II Di Napoli” in Italy, and my second master’s degree in Human Movement Sciences, with a specialisation in Sport and Nutrition, at Maastricht University.

At BioActor, we highly value clinical research because it plays a crucial role in providing evidence-based ingredients. What does clinical research entail and what do you like about it?

Sanne: Clinical research entails many different processes. This includes idea formation and initial literature searches, finding collaborations, obtaining ethics approval, practical work, data analyses, writing reports and papers, and communicating our results at national and international conferences.

Maria: A very interesting part for us is the ideation of the study. At BioActor we highly value innovation, which is why before starting a new clinical trial, we sit in brainstorming sessions with the R&D, marketing and sales teams to try to find white spaces in the current knowledge that can be of interest for the common public and different health domains. Once we find an interesting and never explored topic, the investigation can start.

Could you briefly take us through the process of a clinical trial?

Sanne: First, we initiate the idea formation process by brainstorming ideas that are relevant to customer questions or explore new areas of interest. Next, we perform literature searches to look for relevant papers, available data, and discover white space; topics that have not yet been researched.

Then we reach out to a collaborator, usually a professor at a University, to work with on developing a protocol for ethics review.

Maria: Once we obtain ethics approval, we dive into the practical phase of the clinical trial. This involves engaging with participants through visits where we collect data. This includes not only traditional data that we can extrapolate by collecting blood samples, but also performing tests to evaluate outcomes like reaction time, exercise capacity and mental flexibility.

It’s an interactive and rewarding experience that brings our research to life and allows us to better understand how our ingredients contribute to improving human health and develop evidence-based solutions. Afterwards, we analyze the data, draw conclusions, and share our findings through peer-reviewed publications. It’s a cool journey from start to finish!

Which of the above do you enjoy the most as a scientist?

Sanne: I enjoy collaborating with other companies or academic institutes! It’s such an incredible opportunity for us to broaden our knowledge and take our research to the next level. The energy and creativity that come from working with diverse teams is truly great.

Maria: The practical side of our work is always interesting! Collecting data means we get to perform visits with participants, and trust me, it’s never boring when you’re involved in a human study. The hands-on experience and the constant interaction with people make it such an exciting and fulfilling part of our job.

What is the biggest challenge in designing a study?

Sanne: In my opinion, the biggest challenge in designing a study is obtaining ethics approval, which is a rigorous and time-consuming process. We meticulously prepare documents explaining our research goals, methodology, and participant recruitment.

The ethical committee thoroughly reviews these documents, granting final approval for each aspect of our research.

Maria: I agree! Obtaining ethics approval is a significant challenge. However, this process is crucial for upholding ethical standards and protecting participant rights.

It also adds credibility to our research, fostering trust and allowing our findings to have a greater impact. Despite the challenges, navigating the ethics approval process is vital for conducting valuable and ethically sound research.

What is the best part of working at BioActor as a scientist?

Sanne & Maria: Being a scientist at BioActor is truly rewarding due to the chance to collaborate with a dynamic and passionate team of international colleagues. Within BioActor, we also see other aspects of the company besides R&D.

Our weekly company meetings allow us to really understand the bigger picture of the company and understand what each department entails. Consequently, we explore different facets of the company and gain valuable insights beyond our specific research and development focus.

BioActor: Using clinical science as the key to innovative ingredients

Sanne Ahles and Maria Imperatrice exemplify the passion and dedication that drive BioActor’s pursuit of finding new health effects of ingredients and advancing scientific innovation. From ideation to practical implementation, data analysis, and knowledge dissemination; they are pushing the boundaries of scientific knowledge and embracing the multidisciplinary nature of their work. Sanne and Maria contribute to BioActor’s mission of creating innovative and impactful solutions for a healthier life.


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New publication demonstrates potential of Naxus® for alleviating IBD through gut microbiota alterations and increased butyrate production in mice

New publication demonstrates potential of Naxus® for alleviating IBD through gut microbiota alterations and increased butyrate production in mice

Maastricht, The Netherlands, 1st May 2023

Press release
In the present study published in Molecules, the leading international, peer-reviewed, open-access journal of chemistry, the authors evaluated the potential positive effects of arabinoxylans (AX) contained in Naxus® on T-cell-dependent colitis. The findings of the study showed that Naxus® was able to induce peripherally induced Treg (pTreg) cells in the colon. This resulted in a reduction of T-cell-dependent chronic colitis due to the increased levels of butyrate-producing bacteria and luminal butyrate levels. These findings implicate that there could be a role for Naxus® in the treatment of inflammatory bowel disease.

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Naxus®: a product researched and developed by BioActor

NAXUS®, an arabinoxylan extract obtained from the endosperm of wheat and is known for its beneficial health effects.

Wheat arabinoxylans (AX) are, in turn, a type of non-starch polysaccharide found in the cell walls of wheat grains. AXs are typically composed of a linear β (1-4)-linked xylan backbone with side residues of a-1-arabinofuranose units attached via α-(1-3) and/or α-(1-2) linkage.

Several clinical studies have shown that Naxus® is a powerful and well-tolerated prebiotic which induces a positive effect on the immune system and blood sugar levels by modulating the microbiome composition and Short Chain Fatty Acids (SCFA) production.

Effect of Naxus® on the Gut Microbiota Composition and Colonic Regulatory T Cells: in vitro and in vivo study

Introduction

The study was conducted by the group of Seita Chudan and the groups’ aim was to to understand the effect of wheat-derived arabinoxylan on gut microbiota, colonic regulatory T cells (Tregs) which are a specific subset of T cells that suppresses the immune response, and experimental colitis, this way, discussing the importance of a healthy gut microbiota and its connection to immune function and disease.

Many studies have looked at how AXs from wheat affect the bacteria and compounds in our gut, as well as a type of antibody present in the immune system called Immunoglobulin A (IgA).
However, not many studies have shown how AX might be helpful in treating Inflammatory Bowel Disease (IBD), a condition that is characterized by inflammation of the GI tract. One recent study has looked at how AX might help with a type of IBD called DSS-induced colitis, but it’s still unclear if AX can prevent colitis.

Therefore, it is important to understand how wheat AXs affect the immune system and colitis, particularly in cases caused by the acquired immune system.

Methods

In this study, healthy and chronic colitis model mice were fed with food containing cellulose or Naxus® for 2–6 weeks and subjected to subsequent analysis of the gut microbiota composition and the number of colonic regulatory T cells in both groups.

Results

The results of this study indicate that Naxus® promotes the development of colonic pTregs and helps to reduce T-cell-dependent chronic colitis. The number of colonic regulatory T cells was significantly higher in the Naxus® group compared to the control group. These positive effects may be due to changes in the gut microbiota and increased levels of short-chain fatty acids (SCFAs), especially butyrate.

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Table 1: Quantification of fecal SCFA in mice fed with food containing CE (cellulose) or AX (n = 8)

Butyrate is produced by certain bacteria in the Lachnospiraceae family, such as Eubacterium and Roseburia spp., Increases in Lachnospiraceae bacteria were linked to an increase in fecal butyrate concentration and a greater number of colonic Tregs in the Naxus®-fed mice.

In a T cell transfer model of chronic colitis, Naxus® was found to improve body weight loss and reduce colonic tissue inflammation, possibly through Treg induction. In addition, in this colitis model, wheat-derived arabinoxylan decreased TNFα production from type 1 helper T cells.
Therefore, Naxus® could be a useful prebiotic for preventing colitis by modifying the gut microbiota and shifting the metabolite production more towards butyrate.

Conclusion

This study shows that Naxus® has positive effects in a mouse model of chronic colitis. These improvements are linked to the alterations in the gut microenvironment by regulating the gut microbiota composition and increasing the number of colonic regulatory T cells, which could have implications for the prevention and treatment of inflammatory bowel disease and other immune-related diseases.

Click here to read the complete publication

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.
Feel free to contact via info@bioactor.com for more information on the possibilities Naxus® has to offer.
Further information can also be found on: www.naxus.nl.


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Exploring the ways blood sugar impacts your health

Exploring the ways blood sugar impacts your health

April 20th, 2023

Are you aware that your blood sugar levels can change frequently, and it is important to maintain a stable level in order to improve your overall health? In this article, you will get acquainted with the reason your blood sugar levels might fluctuate, the effects of these changes on your health, and tips to help you on maintaining a stable blood sugar level.

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Sugar and blood sugar levels

Sugars and carbohydrates are widely consumed substances across the world. They play a vital role in providing energy to the body and in regulating the blood sugar levels, or blood glucose levels, throughout the day (1).

After a meal, our metabolism works to keep our blood sugar levels steady. It does this by reducing the production of sugar (glucose) and promoting its storage as both short-term and long-term energy reserves (2).

The way your body metabolism responds after eating depends on the type of sugar you consume – simple sugars or complex sugars (1). Foods such as sugar-sweetened foods, beverages, and refined grains are a source of simple sugars, which are associated with higher increases on blood sugar levels.

Sources of complex sugars include minimally processed grains, legumes, and whole fruits. These are considered as a better option to maintain a steady blood sugar level.

When simple sugars and complex sugars are consumed in excess, or under consumed from processed food sources, acute and/or chronic conditions might arise as consequences.

What happens if your blood sugar levels are too high?

We already know that high blood sugar levels might have negative impacts on our health. Stress, some sort of medications, insulin resistance and an unhealthy lifestyle are the core of the increasing of the blood sugar levels (2,3).

Usually, people with higher blood sugar levels tend to experience an increase in feeling thirsty and they have a higher urinating frequency. Experiencing blurred vision, headaches, and fatigue are also symptoms.

On the long term, high blood sugar levels are associated with an increased risk of obesity, type 2 diabetes, heart disease and other organ damages, like nerves, eyes, kidneys, and brain (3).

What happens if your blood sugar levels are too low?

On the other hand, the low blood sugar levels might also have negative impact on your health, occurring when you don’t eat enough carbohydrates according to your nutritional requirements or when the physical exercise is inappropriate in contrast to your food intake (2).

If your body is deprived of having enough fuel to sustain life, the central nervous system won’t be able to synthesize glucose, store, or concentrate glucose from the body circulation (4). As consequence, a brief decrease on the blood sugar levels might cause severe central nervous system dysfunction, and a prolonged decrease might cause cell death and coma.

Commonly, but depending on the severity and duration of the low blood sugar level, people tend to experience shakiness, confusion, irritability, sweating, and a fast heartbeat.

Strategies to maintain a stable blood sugar level

To begin with, it is important to understand what the normal blood sugar levels are. A fasting blood glucose level between 70 and 99 mg/dL is considered normal regardless of some variations caused by diet, physical exercise or medication as mentioned before (12).

When the blood sugar levels are higher or lower than this level some strategies need to be considered:

1. Implementing a healthy diet according to your nutritional needs is one of the strategies to maintain a stable blood sugar levels (5).
Specifically, consuming high in fibre foods such as foods rich in whole grains as source of arabinoxylans seems to be a good adding to a healthy diet along with fruits and vegetables (6). Curious about arabinoxylans? Read our article here.

What’s more? Lean proteins, and healthy fats and limited added sugars consuming are as well associated with better blood sugar control.

2. Physical exercise is an essential part of a comprehensive lifestyle changing (5). Studies have shown that both aerobic and resistance training have positive effects, and that combining the two types of exercise has even more positive effects. This way, combining a healthy eating with physical exercise is crucial on stabilising the blood sugar levels and maintain a healthy weight balance.

Why is it important to keep blood sugar stable?

Summarising, having high blood sugar levels increase the chances of developing obesity, diabetes, and heart disease. On the other hand, having low blood sugar levels can cause problems with cognitive function and other complications. This way, adopting a healthy diet, being physically active, and controlling your weight might helping you on maintaining a stable blood sugar levels and lower the risk of experiencing these adverse health effects.


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MEET US - BioActor Presenting MicrobiomeX® and Naxus® at the 15th Annual IPC conference

MEET US – BioActor Presenting MicrobiomeX® and Naxus® at the 15th Annual IPC conference

Maastricht, The Netherlands, June 16th, 2022

Press release
The 15th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health – IPC2022 will be held during 27 – 30 June 2022 in Bratislava. BioActor is an active contributor and confirmed partner of this conference. Hans van der Saag (CEO) will present on our ingredient Naxus®, a prebiotic with metabolic and immune effects, and Yala Stevens (CSO) presents the clinical and mechanistic research on MicrobiomeX® in irritable bowel syndrome (IBS) patients and elderly subjects.

prebiotics-and-probiotics

BioActor Presenting MicrobiomeX® and Naxus® at the 15th Annual IPC conference

The 15th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health – IPC2022 will be held during 27 – 30 June 2022 in Bratislava.

The IPC conference is the world’s biggest scientific conference that focuses solely on basic and applied research of probiotics, prebiotics, gut microbiota and health. More than 400 scientists from over more than 80 countries have attended the conference last season.

The scientific program will focus on current advances in the research, production and use of probiotics and prebiotics with particular focus on their role in maintaining health and preventing diseases. At IPC, leading scientists from industry and academia present current advances in understanding and influencing the interaction between gut microbiota and human health.

The conference enables the interactive exchange of state-of-the-art knowledge. It is focused on evidence-based benefits, health claims proven in scientific experiments and clinical trials.

BioActor is an active contributor and confirmed partner of this conference. Hans van der Saag (CEO) will present on our ingredient Naxus®, a prebiotic with metabolic and immune effects, and Yala Stevens (CSO) presents the clinical and mechanistic research on MicrobiomeX® in irritable bowel syndrome (IBS) patients and elderly subjects.

Naxus® presentation by Hans van der Saag (CEO)

Naxus® is a native arabinoxylan extract from the wheat endosperm. It is a powerful and well-tolerated prebiotic with metabolic and immune effects. Due to its complex branched structure, Naxus® is slowly and selectively fermented by multiple species of the microbiota, inducing a remarkable bifidogenic effect without causing gas formation and intestinal discomfort. It induces a remarkable microbiota shift and increased short-chain fatty acids production, with proven effects on immune health and glycemic control.

MicrobiomeX® presentation by Yala Stevens (CSO)

MicrobiomeX® is a natural extract from citrus fruit designed to beneficially modulate the microbiome composition in the gut. It’s a first-in-class Flavobiotic® that protects the gut barrier and directly leverages the gut microbiome’s potential. This results in enhanced immune health, as well as anti-inflammatory effects.

IBS is a functional gastrointestinal disorder with various symptoms including pain and discomfort in the abdomen. Also, elderly often develop imbalances in their gut microbiota and often experience discomfort.

Patients with IBS and elderly would benefit substantially from treatments that could relieve their symptoms and improve their gut health. The flavonoids in MicrobiomeX® have the potential to benefit individuals with gastrointestinal conditions because of its antioxidant and anti-inflammatory properties.

Business opportunities

The IPC conference is a great opportunity to reconnect with colleagues from all over the world and make new contacts. Hans van der Saag (CEO) and Yala Stevens (CSO) will be there to represent BioActor’s portfolio, with a focus on our gut health ingredients. Feel free to pass by at any time to chat about our innovative ingredients for gut health support!

We look forward to meeting you in Bratislava!

The IPC 2022 conference will take place from 27 to 30 June 2022.

Where: Hviezdoslavovo námestie 3, 811 02 Bratislava, Slovakia

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that supplies proprietary bioactive formulations to the nutrition & healthcare industry. The company focuses on the development of innovative bioactives that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

For further information, see www.bioactor.com or visit https://microbiomex.com/ or https://naxus.nl/