A promising ingredient for gaming supplements

Brainberry® – A promising ingredient for gaming supplements

Brainberry® – A promising ingredient for gaming supplements

Last updated: May 17th, 2024

January 11th, 2022

Brainberry® is an Aronia melanocarpa extract that provides an innovative and natural way to boost gaming performance in a safe and effective way. If you plan to get rid of typical sugar- and stimulant-loaded supplements and energy drinks, Brainberry® may be the healthier alternative you are looking for. Thanks to its high content in functional anthocyanins, it promises to enhance gamers’ experience by providing sustained crash-free energy, as well as clinically proven brain benefits. Read more about why this ingredient is important for your gaming supplement!

A promising ingredient for gaming supplements

Why are supplements relevant for gaming?

Gaming has grown exponentially over the last few years, not only in amateur gamers but also in professional ones– eSports.

If you are a gamer, you may have already noticed that gaming requires an incredible number of mental skills. Indeed, gaming is continuous and with very few breaks. Therefore, you need to manage a high cognitive workload, especially if your session lasts for an extended period of time.

Moreover, the visual-spatial skills are essential. These abilities allow you to analyse, recognize and rapidly respond to changes on the screen. In addition, as gaming sessions can last for hours, enhanced attention and focus are crucial. You need to have the skills to stay focused and alert, without getting sleepy and distracted.

Lastly, when gaming, it is important that you manage emotions, such as anger, anxiety and stress, as these can negatively impact your performance.

Even though nutrition has been often overlooked by most gamers, the supplement industry for this segment is growing exponentially, showing that more and more attention is being paid to this important aspect.

Over the last year, several brands have launched gaming formulas on the market and supplement use is continuously increasing amongst gamers looking to up their gaming performance. There is a wide range of products tailored to gamers, ranging from powders to capsules, functional drinks and even gummies.

Whether you are a competitive gamer or not, taking care of your body and mind through proper nutrition, supplements, and rest can yield the best results.

The main problem with most gaming supplements and energy drinks

Supplements have the potential to enhance your cognitive performance when gaming. As mentioned, together with the increased number of gamers, gaming supplement and energy drink interest and consumption have significantly grown in the last years.

However, many of these products contain high amounts of caffeine and sugar. High intakes of these two compounds are generally associated with negative health effects.

After a high caffeine intake, you may experience tachycardia, jitters, headaches or disrupted sleep [1, 2, 3]. In fact, excessive caffeine consumption can negatively impact brain performance. On top of this, high caffeine consumption during the teenage years is associated with an increased risk of suffering from anxiety disorders in adulthood [4].

On the other hand, a high sugar intake may lead to unhealthy weight gain and dental caries, both undesired health effects. Moreover, high sugar spikes in the blood are often followed by an energy crash, which is not ideal when you need to be focused.

If you plan to get rid of typical sugar- and stimulant-loaded supplements and energy drinks, Brainberry® may be the healthier alternative you are looking for.

What is Brainberry®?

Brainberry® is an Aronia melanocarpa extract, standardized for high levels of the anthocyanin cyanidin-3-O-galactoside. This ingredient is clinically validated to improve focus and psychomotor control.

The consumption of anthocyanins has been associated with improved cognition skills, such as memory, attention and psychomotor speed [5, 6, 7].

The active cyanidins present in Aronia berry extract in the form of cyanidin-3-O-galactoside can cross the blood-brain barrier and contribute to brain perfusion.

In the hippocampus, cyanidin-3-O-galactoside lowers acetylcholine esterase activity, which increases acetylcholine, resulting in neuronal signalling. This leads to faster and more accurate reactions due to improved visual processing speed and psychomotor control.

In addition, Brainberry® is water-soluble, easy to formulate and has a pleasant taste. Its possible applications include liquid forms (e.g. ready-to-drink formulas), chewable tablets, gummies, effervescent tablets, stick packs and capsules.

What makes Brainberry® an ideal ingredient for gaming supplements?

Brainberry® is the ideal ingredient for gaming supplements for several reasons:

• 100% natural. It is extracted from high-quality Aronia berries from the Baltics resulting in a completely natural ingredient.

• Clinically proven. It has been validated in 3 randomized, double-blind, placebo-controlled trials.

• Increased visual processing speed. Its hero compound, cyanidin-3-O-galactoside, significantly improves psychomotor control, enhancing eye-hand coordination.

• Tested in gamers. It has been successfully tested in a consumer study with active gamers.

• Low dosage and stimulant-free. The recommended daily dose is 65 mg. It does not contain stimulants, which are usually accompanied by undesired side effects. This makes it a healthier option compared to other solutions with high stimulants.

• High bioavailability. The bioavailability of the active compound in Brainberry®, cyanidin-3-O-galactoside, has been evaluated and demonstrated rapid absorption [8].

• Easy to formulate. Thanks to its excellent solubility and pleasant taste, it can be included it in a wide range of forms (e.g. drinks, gummies, capsules…).

Research with Brainberry®

Double-blind placebo-controlled trial

Brainberry® has been investigated in the first-ever study to link Aronia berry extract to improved cognitive performance. A 12-week double-blind placebo-controlled clinical study that included 101 subjects linked Aronia berry extract (Brainberry®) to a significant increase in psychomotor speed, eye-hand coordination, and focus.

After only 6 weeks of supplementation with 65 mg of Brainberry® daily, a significant improvement in psychomotor speed was observed, with even a further increase for the rest of the trial (12 weeks).

Brainberry psychomotor speed result

After 12 weeks, concentration was increased by 43% in the group supplemented with 65 mg of Brainberry® [9].

Brainberry focus result

Short-term improvements due to Brainberry®

More recently, a new clinical study has been released investigating the short-term effects of Brainberry® on psychomotor speed and BDNF concentration [10].

Participants in the intervention group showed a significant improvement in reaction time compared to the control group.

Moreover, serum BDNF concentrations were significantly higher with 5.7% in the intervention group after 1-week Brainberry® intake (p<0.05). BDNF is a protein responsible for neuronal survival and growth, essential for learning and memory [11] and highly relevant for the purpose of this research. Its increase showcases Brainberry®’s potential to support young adults in their daily activities such as learning and working.

Consumer study with active gamers

Additionally, a consumer study was conducted on active gamers using Brainberry®. 21 healthy young recreational gamers consumed 65 mg of Brainberry® daily for 7 days.

After just one dose of Brainberry®, participants successfully reported a significant improvement in the most relevant measures for gaming performance, such as eye-hand coordination, focus, reaction time and energy.

As gamers need fast-acting noticeable effects, the significant improvements in eye-hand coordination, focus, energy and reaction after a single dose, confirmed the effectiveness of Brainberry®.

What’s perhaps even more important, is that these improvements were sustained after one week of supplementation.

Brainberry gamer study results

As mentioned before, mood is also key during a gaming session. In fact, not being able to deal with difficult emotions (i.e. anger, stress, anxiety) that are likely to arise while competing, negatively impacts performance. Interestingly, the participants in the study reported an improvement in mood parameters after one week of supplementation with Brainberry®.

Another important outcome to point out is that supplementation with Brainberry® did not have any negative effects on fatigue, sleep quality and anxiety levels. It is well-known that these types of complaints are frequently reported by subjects (often gamers) who consume large quantities of sugar- and stimulant-loaded energy drinks.

The bottom line

Brainberry® is an Aronia melanocarpa extract that provides an innovative and healthy solution to boost gaming performance in a natural and safe way. Thanks to its high content in functional anthocyanins, it promises to enhance gamers’ experience by providing sustained, crash-free energy and clinically proven brain benefits.

Brainberry® is the perfect alternative to supplements and energy drinks that are high in sugar and caffeine. It allows limiting these compounds in your diet while offering sustained crash-free energy, as well as clinically proven brain benefits.

new strategy to loose weight

Are there any new strategies for weight management?

Are there any new strategies for weight management?

Maastricht, 10th May, 2024

For many different reasons, almost everyone has been concerned about their weight. Nowadays, we all want to find new effective approaches to control our weight in a healthy, sustainable, and easy manner. Could arabinoxylans be the answer we have been looking for?

new strategy to loose weight

How relevant is weight management?


Weight is a common worry for a large part of society. Whether it is driven by aesthetic preferences or health considerations, almost everyone has thought about losing some weight. Body image and the beauty standard that is stablished in the Western culture plays an important role and pressures many people, particularly women, to lose weight (1).  

However, there is a growing number of people interested in improving their health and quality of life: not only they want to be healthy, but they also want to feel healthy (2). As a result, there is a growing interest in holistic solutions that people can seamlessly integrate into their lifestyle without uncomfortable restrictions .


How to lose weight? 


While it’s true that weight loss ultimately comes down to burning more calories than you consume, many traditional diets and exercise programs are designed as short-term solutions that are difficult to sustain in the long run. However, new alternatives are emerging. For example: 

  • Intermittent fasting is an eating pattern where the individual restricts all the calories that has to eat in a day to a few hours of eat and fasts for the rest of the day (3). Although some studies have shown this helps control weight, evidence is not strong enough (4). This pattern has to be adapted in the long term for it to work, but it is not manageable to many people.  


  • A high protein diet can help with weight management as protein digestion delays the hunger sensation. But for a diet to be consider high in protein (5), about 1.2 g/kg of body weight have to be consumed. In a normal diet, people consume less than 0.8 g/kg of body weight a day. Increasing the protein intake and sustaining it over time can be tricky for some people (6). In addition, people with certain health concerns such as kidney issues are not recommended to follow these diets.  

A new emerging strategy for weight management 


Arabinoxylans are dietary fibres found in the cell walls of plants, such as grains like wheat (7). As many dietary fibres, arabinoxylans are polysaccharides that help with gut health. They act as prebiotics, food components that are not absorbed by the intestine, but rather support digestion and the health of the gut microbiome. 


Research shows that arabinoxylans have the ability to regulate the postprandial (after-meal) glucose response (8). By controlling spikes in blood glucose levels, they can help regulate appetite. A more controlled glucose response is associated with a lower appetite, which usually translates in a decrease in calorie intake (9), an essential factor for weight loss and maintenance.  


What is the clinical evidence – can arabonoxylans help in weight management? 


A recent study (10, 11) with such arabinoxylans – Naxus® and inulin suggests that arabinoxylans could be a great ally for weight loss management. Participants who consumed arabinoxylans had a significant decrease in their calorie consumption, meanwhile their self-reported appetite did not decrease. 


It is believed that the increase in beneficial bacteria, such as Bifidobacterium and Propionibacterium, led to an increase in production of short-chain fatty acids (SCAFs). Additionally, there was also an increase in acetate, which can have an effect on appetite independently, explaining the study’s results.  


Including arabinoxylans in strategies for weight loss could be more approachable for a certain type of consumers that struggle to change their eating habits. This approach would not require a complete change of their routine, adding products enriched with arabinoxylans to their diet could make a significant difference.  




Whether it is for health concerns or aesthetic reasons, weight management is in the mind of many people. Our society wants to be and to feel healthy. Weight loss can be difficult to many people and most strategies are not sustainable in the long term. Adding arabinoxylans to the diet has proven to be an innovative and approachable solution that can be adopted by many people.  

Immature Oranges

Why are immature oranges a sustainable source for citrus extracts?

Why are immature oranges a sustainable source for citrus extracts?

Last updated: May 3rd, 2024

June 28th, 2023

Nature is fascinating and citrus trees are no exception. These fruit-bearing trees, known for their refreshing oranges, have a remarkable way of sustaining themselves through a process of natural selection, which is better known as the fruit drop. In this article, we will explore what immature oranges are, shedding light on their origin, the growth process of orange trees, and the sustainable practices employed by nature itself.

Immature Oranges

Orange trees grow more oranges than they can sustain

During the summer, an orange tree bursts into a profusion of flowers, each one holding the promise of an orange. However, the tree faces a conundrum. It cannot possibly sustain all the blossoms it produces, as doing so would drain its resources and hinder its overall health. Consequently, the tree must decide on the number of oranges it can support adequately.

This decision is made by looking at which oranges the tree wants to fully grow and dropping the immature oranges that it decides are no longer able to grow.

Why does an orange tree drop immature oranges?

As the oranges begin to develop, the tree undergoes a natural selection process. It assesses its capacity to sustain the growing fruits and makes calculated choices to ensure its long-term well-being.
At this early stage, the tree drops the tiniest, most immature oranges, which are often just a few millimetres in size. This process is called fruit drop [1].

Fruit drop occurs when a fruit tree produces more fruits than it can adequately support to maturity. The tree goes through a natural thinning process in which it sheds a certain number of immature or underdeveloped fruits. This thinning is essential for the tree to allocate its resources efficiently and ensure that the remaining fruits have enough nutrients and energy to reach maturity.

Several factors can contribute to fruit drop. Some of the common reasons include:

1. Limited resources: The tree may not have enough resources, such as water, nutrients, or sunlight, to support the growth of all the fruits it has set.

2. Competition: When there are too many fruits on a tree, they may compete with each other for resources, leading to the shedding of some fruits.

3. Pollination and fertilization issues: If pollination or fertilization processes are incomplete or unsuccessful, the tree may drop the unfertilized or poorly developed fruits.

4. Environmental factors: Adverse weather conditions, such as frost, extreme heat, drought, or strong winds, can also cause fruit drop.

5. Disease or pest infestation: Certain diseases or pest attacks can result in the dropping of fruits as a defence mechanism by the tree [2]

Fruit drop is a natural mechanism that helps the tree optimize its resources and produce healthier fruits. It is a common occurrence in many fruit-bearing trees, and growers often expect some level of fruit drop during the growing season.

Immature oranges: a sustainable source of citrus extract

Though the tree drops the immature oranges to sustain other oranges, this does not mean that the immature oranges are not full of nutrients. On the contrary, these immature oranges have very high levels of the hero-compound hesperidin that Solabia Nutrition’s citrus extracts are standardized for.

To utilize their potential, these immature oranges must undergo a specific drying process. The moisture is carefully removed, transforming them into dried fruits. Once the oranges are fully dried, the extraction process begins, unlocking the hesperidin. This compound is a type of flavonoid that has many beneficial health effects.

The process of getting immature oranges is not only sustainable because the fruit drop is a natural process, but also because of the way pests are controlled via biological control [3].

How biological control preserves the quality of the immature oranges

A sustainable practice employed by orange tree farmers is biological control, which involves the deliberate use of natural enemies to combat pests. Instead of relying on harmful pesticides, farmers harness the power of nature’s allies to protect their citrus trees, including the immature oranges.

Beneficial insects, such as ladybugs and lacewings, are introduced into the orchards to prey on pests like aphids and caterpillars that can harm the immature oranges. This method, known as biological control, helps maintain a balance in the ecosystem by reducing pest populations naturally and safeguarding the growth of immature oranges.

By embracing this approach, farmers can minimize the use of pesticides, thereby protecting the environment and preserving the health of the citrus trees and their valuable immature oranges.
This sustainable practice not only ensures the quality of the oranges but also fosters a harmonious relationship between agriculture and nature, promoting a healthier and more environmentally friendly farming system.

The most interesting part of immature oranges: Hesperidin

Hesperidin, a bioactive compound found abundantly in citrus fruits like oranges, possesses numerous health benefits. It’s a powerful flavonoid that has been extensively studied by Solabia Nutrition for its effect on gut health and in its micronized form: its effect on sports performance.

By utilizing the immature oranges’ dried form, the extraction process harnesses hesperidin’s potency, providing an eco-friendly and sustainable approach to its production.

During Solabia Nutrition’s visit to the orange fields in Spain that are the source of the immature oranges for our extracts, we had the privilege of learning about the orange trees’ natural fruit drop from our orange farmer.

The dried immature oranges, sourced from these carefully selected fields, serve as the foundation for our citrus extracts. By partnering with nature and respecting its processes, we strive to provide ingredients that are not only of the highest quality but also sustainably produced.

adult nutrition formulas

What are adult nutrition formulas?

What are adult nutrition formulas? Types and health goals 

Maastricht, 26th April, 2024

Adult nutrition formulas represent a category of functional food products that is gaining growing popularity these days. Though such powder products were originally designed as meal replacements for weight management, adult nutrition formulas have found new relevance among adults to reach a broad range of health and nutritional goals due to their convenience, versatility, and nutritional value.

adult nutrition formulas

What are adult nutrition formulas?

These products encompass a variety of supplemental foods aimed at providing consumers with a complete and nutritious meal. These formulas typically come in ready-to-drink shakes or plant- or milk-based powders that can easily be solubilised in water or other liquids [1].

While milk-based powders have traditionally dominated the market, plant-based formulas are gaining traction and are expected to gain market share.

Typically, these formulas are fortified with functional ingredients such as vitamins, minerals, fibers, and proteins to address specific consumer health goals, such as weight management, sports performance enhancement, or diabetes control [2]. Due to the popularity of these customisable supplements, new formulas are emerging rapidly.

Even though these products have targeted health aims, many of these formulas offer a comprehensive nutritional profile suitable for any individual seeking a convenient and balanced meal option. The powdered form or the pasteurised shakes grants them an extended shelf life and versatility, making them ideal for on-the-go consumption. A typical example of the latter is breakfast drinks with prebiotic fiber like arabinoxylans which are both healthy and keep you satiated for a couple of hours.

These advantageous properties make adult nutrition formulas suitable for various lifestyles, including those with busy schedules or specific dietary requirements.

Advantageous attributes of adult nutrition formulas

Adult nutrition formulas offer numerous advantages, making them highly appropriate for various lifestyles. Below are additional beneficial attributes of adult nutrition formulas:

  • No need for cold storage: powders and pasteurised shakes are very stable and resistant to spoilage, mould, or other factors affecting shelf life. This eliminates the need for cold storage, enhancing convenience for consumers.
  • High solubility and dispersibility: the products have strong soluble properties, making them highly suitable for mixing with nutrients such as plant extracts and speciality fibers such as arabinoxylans. Their ability to dissolve and disperse easily in liquids ensures a smooth and uniform texture.
  • Low/no sugar content: powders or ready-to-drink shakes often contain little sugar, making them a healthy food choice for the average consumer.
  • Low allergen: many adult nutrition formulas are free of allergens such as gluten, dairy, soy, and nuts. This makes them suitable for individuals with food sensitivities or allergies, broadening their accessibility.
  • All natural: depending on the brand, adult nutrition formulas are crafted with all-natural ingredients, free from artificial additives or preservatives.
  • Nutrient-dense: adult nutrition formulas are packed with essential nutrients per serving, providing a convenient way to meet daily nutritional needs.
  • Tailored health attributes: due to their customizable properties, adult nutrition formulas can be adjusted to any health goal.
  • Carrier for health claims: given the pack size, there is ample space both in the powder and – literally – on the label to use ingredients with health claims.
  • Part of daily ritual: since adult nutrition formulas offer the possibility of a completely nutritious and healthy serving, consumers will be encouraged to include these products in their daily routines and rituals.

Next generation: benefits beyond general nutritional support

The emerging trend of adult nutrition formulas reflects a growing demand for functional nutrition beyond basic dietary needs. While initially designed to address weight management or ‘special medical purposes’ (medical nutrition drinks such as Boost and Ensure), adult nutrition formulas have evolved to incorporate functional ingredients tailored to meet diverse health goals, particularly among middle-aged and older consumers.

Young consumers are also drawn to this part of the functional food market, particularly breakfast drinks, which offer a complete nutrition profile and sustained satiation throughout the morning. The next step in breakfast drinks is to add speciality prebiotic fiber, such as arabinoxylans, which carries a fiber claim, a health claim and contributes to a sense of fullness thanks to its viscous properties. Health-conscious individuals integrate these breakfast drinks into their dietary routines as a mindful choice.

In addition, this on-the-go product can further be enhanced to support workout or endurance sports. For example, breakfast drinks enriched with electrolytes, caffeine, branched-chain amino acids or creatine.

Health benefits of adult nutrition formulas

The formulas are designed to serve various health goals, with formulations tailored to meet specific nutrition needs. The powders were originally designed to replace complete meals. However,  these formulas have evolved to incorporate targeted health benefits, particularly for middle-aged and older consumers. Below, common health benefits including corresponding ingredients are listed:

  • Weight Management: high protein and prebiotic speciality fiber (such as arabinoxylans), variety of vitamins and minerals, and low carbohydrate and sugar content. Weight management formulas have evolved from complete meal replacement products to targeted nutrition for reducing calorie intake or satiation.
  • Immune Support: rich protein content, variety of vitamins and minerals, and speciality fibres (such as beta-glucans and arabinoxylans [3]). Examples of immune-supporting formulas are Ensure Nutrivigor, and the new Actimel Plus in larger multi-serving bottles.
  • General Well-being: various vegetable and fruit extracts, fibres, protein and omega-3 fatty acids. These formulas are ideal for breakfast drinks, such as Weetabix on the go, UP&GO Breakfast Shake, and Naked Juice Core.
  • Sports Enhancement: classical formulas are high in protein and branched-chain amino acids (BCAA). More recent launches combine macronutrients with functional micronutrients such as citrus flavonoids, creatine, or beta-alanine. Examples of such products are ESN Perfect Pre and Shape Code Protein Shake.
  • Diabetes Control: high in soy and whey proteins, fibre (such as arabinoxylans [4]), and MCTs. Product examples are BOOST Glucose Control and FontActiv DiaBest.
  • Bone Health; high calcium, protein, collagen, magnesium, vitamin D, C and zinc. Popular product examples are ANLENE Gold 5X and Nature’s Way BoneHealth.
  • Digestive Health; prebiotic fibres (such as arabinoxylans [5]), probiotics, and omega-3 fatty acids. Examples of consumer products include MegaMucosa or Upfront Prebiotica.

The regulation of adult nutrition formulas

The regulatory status of adult nutrition formulas can vary depending on their intended use and formulation. In general, these products are classified as either foods, dietary supplements, or food for special medical purposes (FSMP), each subject to different regulatory frameworks.

Regulated as foods or supplements?

If the adult nutrition formula is intended to be consumed as a regular part of the diet, and does not make specific claims about treating or preventing diseases, it is typically regulated as a conventional food. In this case, it must comply with food labelling and safety regulations set by the relevant authorities, such as the FDA in the United States, or the EFSA in the European Union.

In the EU, supplements are regulated as foods and must therefore adhere to the food directives set by the EU. In the United States, however, dietary supplements must adhere to regulations set by the Dietary Supplement Health and Education Act (DSHEA).

Many Asian countries will consider adult nutrition formulas as food products, which often means that no prior registration is required, but also that no health claims are allowed. This is notably the case in Malaysia, China and Korea.


Regulated as medical foods

Foods for special medical purposes (FSMP) include oral nutritional supplements and enteral tube feeding. The definition of this varies across regions of the world.

In the EU, these foods should adhere to specific legislation and are intended for consumers whose nutritional requirements cannot be met by normal foods. These products require pre-market authorizations before they can be placed on the market. There must be scientific evidence supporting the safety, quality, and efficacy of the product. Interestingly, if such scientific evidence is available, medical claims are allowed, without having to go through the EFSA health claim route.

In the US, medical foods are regulated under the Orphan Drug Act which provides incentives for the development of products for rare diseases or conditions. These products must adhere to specific criteria, requiring that the medical food provides a medically essential nutritional component that cannot be obtained through a normal diet. Moreover, medical foods need to be taken under the supervision of a medical practitioner.

Growing popularity of adult nutrition formulas

The growing popularity of adult nutrition formulas is evidenced by the significant market growth. Initially developed for infants to ensure adequate intake of essential nutrients, these formulas attracted older populations seeking convenient, nutritionally complete meal options [6].

To illustrate, the global adult milk powder market size was $7150.54 million in 2022 and the market is projected to double by 2031, exhibiting a compound annual growth rate (CAGR) of 9.09% during the forecast period [7].

Particularly in the Asia-Pacific region, demand is on the rise, attributed to factors such as ageing populations and concerns for bone and muscle health. This is, for example, shown in China, where a declining birth rate has led to increased interest in adult nutrition formulas [8,9].

This emerging trend in adult nutrition formulas holds great promise for the future development of these functional food products. The high demand for nutritious food, that is customisable to consumer needs offers great potential and promising plans for the future. For instance, breakfast beverages fortified with arabinoxylan fibres exemplify this potential.

WATTS'UP® in sports nutrition supplement

6 reasons to use WATTS’UP® in your sports nutrition supplement

6 reasons to use WATTS’UP® in your sports nutrition supplement

Last updated: April 19th, 2024

July 14th, 2023

Over the past years, the consumption of dietary supplements has become more widespread amongst both athletes and non-athletes. Athletes, in particular, have taken to these supplements to boost their athletic performance, speed up recovery, and prevent injuries. For product developers, it can be hard to decide which ingredients to include in their sports nutrition supplements. In this article, you will get to know more about the health benefits of our citrus extract WATTS’UP® and 6 reasons to include it in your sports nutrition supplement.

WATTS'UP® in sports nutrition supplement

Beneficial effects of antioxidants for sports nutrition

Polyphenols are molecules present in many fruits. They have attracted attention for their ability to act as antioxidants and reduce inflammation [1]. Studies have shown that polyphenols from citrus, pomegranates, and blueberries can alleviate muscle pain after exercise and enhance muscle strength [2].

Additionally, flavonoid supplementation has been found to enhance endurance exercise performance in humans.

Therefore, Solabia Nutrition, previously known as BioActor, researched and developed a unique sports nutrition ingredient called WATTS’UP®. This is a natural ingredient, extracted from Citrus sinensis and standardized for highly bioavailable hesperidin.

WATTS’UP® has been designed to improve performance in both endurance and strength disciplines, making it a high-quality ingredient for supplements in the sports nutrition market. For this reason, we would like to delve into 6 reasons to use it in your sports nutrition supplement.

1. WATTS’UP® increases production of nitric oxide for optimal blood flow

Hesperidin, the main component in WATTS’UP® can boost the cells that form the lining of our blood vessels by promoting the production of nitric oxide [3]. This substance induces the muscles in our blood vessels to relax and expand, facilitating blood flow.

As a result, blood circulation increases leading to a decrease in blood pressure, as well as an increase in the supply of oxygen and nutrients to the muscles during physical activity, thereby reducing fatigue.

2. WATTS’UP® directly affects the mitochondria

The mitochondria play a vital role in providing energy obtained from food into ATP (Adenosine Triphosphate), which is the energy source that the muscles need for physical activity [4].

Inside the muscle cells, WATTS’UP® increases the efficiency of mitochondria, allowing these organelles to produce much-needed energy in a more efficient way [3]. Simply put, WATTS’UP® makes sure that the mitochondria do not lose any of their potential to create energy, meaning that less energy is lost without the production of ATP.

3. WATTS’UP® increases sports performance in trained athletes and recreational gym-goers

Performance booster for trained athletes

A placebo-controlled double-blind study investigated the long-term effect of a daily dose of 500mg of WATTS’UP® supplementation on highly trained athletes.

After 4 weeks of supplementation with 500mg of WATTS’UP®, a strong increase in anaerobic power (p=0.03) was observed, as well as a sustained superior aerobic-derived power throughout the whole exercise. The tested individuals spent 10 hours per week biking, meaning that even in highly trained individuals, WATTS’UP® can give you the power to go that extra mile.

Performance booster for moderately trained individuals

Furthermore, a placebo-controlled and double-blind study investigated the effect of a daily dose of 400mg of WATTS’UP® on peak power in moderately trained subjects.

The results showed an increase in average peak power (p<0.001) as well as a significant increase in peak power within the first five seconds (p=0.020) after 4 weeks of supplementation. This means that WATTS’UP® is not only able to help highly trained individuals, but also gym-goers.

Read more about these studies in our white paper for WATTS’UP®.

4. Higher bioavailable

WATTS’UP® was specifically developed and has been micronized for improved bioavailability and rapid uptake [5].

To illustrate, a bioavailability study in humans showed that metabolites of WATTS’UP® reached the bloodstream after only 15 minutes of consumption to boost performance right from the start, enhancing the power during the exercise.

This makes WATTS’UP® a great ingredient to include in your sports nutrition supplement.

5. Natural powder and easy to formulate

WATTS’UP® is a clean and natural ergogenic sports performance ingredient, which is why it is a great addition to boost any sports nutrition formula. It has a neutral taste and is easily combined with electrolytes, BCAAs, creatine or caffeine in powder blends, capsules, effervescent tablets, beverages, and gummies.

Curious about which ingredients a pre-workout formula should include? Find out more!

6. WATTS’UP® is sustainably sourced

Moreover, WATTS’UP® is made from immature oranges that are sustainably sourced. During the growth of an orange tree, the tree has to decide which fruits are the most promising ones. To sustain these high-quality oranges, the tree has to allocate its resources to them. This means that the less promising oranges are dropped from the tree in a process that’s called ‘Fruit drop’.

That these immature oranges are dropped, does not mean that they are not full of valuable nutrients! For this reason, we collect this byproduct of orange trees to create our citrus extracts.

Read more about this process here!

WATTS’UP®, the key ingredient for your sports nutrition supplement

In summary, WATTS’UP® increases aerobic and anaerobic power through a direct effect on the mitochondria showing positive effects on peak force, anaerobic power, and endurance performance. Therefore, this ingredient is the ideal sports supplement for both trained athletes and active people who want to get nutritional support for their physical exercise.

Because it is an innovative and science-based ingredient, it will add differentiation and help your supplement of getting a defined and solid positioning on the market. This makes WATTS’UP® an important ingredient in creating a successful sports supplement product.

Discover YAMAMOTO’s Success Story

Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.


Hesperian supports mitochondrial function

How can we support mitochondrial function?

How can we support mitochondrial function?

Maastricht, 14th April, 2024

Supporting mitochondrial function is essential for maintaining overall health. Mitochondria serve as the cell’s powerhouses, responsible for energy production. Thus, maintaining mitochondrial health is key to cellular vitality and well-being.

Hesperian supports mitochondrial function

The Key to Enhanced Mitochondrial Function

Hesperidin, a flavonoid abundant in citrus fruits (1), exerts multiple positive effects within cells. It acts as an effective scavenger of free radicals, safeguarding cells from oxidative damage. Specifically, hesperidin impacts mitochondrial function through several pathways:


Enhanced Efficiency: Research suggests hesperidin can boost mitochondrial efficiency, leading to improved cellular energy production (2).

Mitochondrial Protection: Hesperidin’s antioxidant properties are pivotal in shielding mitochondria from oxidative damage. It scavenges harmful radicals and helps preserve mitochondrial integrity, preventing dysfunction induced by oxidative stress (3).

Improved Resilience: Studies suggest hesperidin enhances mitochondrial resilience against various stressors, including environmental toxins and metabolic challenges (3). By reinforcing mitochondria’s adaptive capabilities, hesperidin supports overall cellular health and longevity.

Reduced Inflammation: Chronic inflammation can compromise mitochondrial function and induce cellular damage. Hesperidin’s anti-inflammatory properties help mitigate inflammation, indirectly supporting mitochondrial health (4).

Cardiovascular Benefits: Some research indicates hesperidin may support cardiovascular health by enhancing mitochondrial function in cardiac muscle cells (5), potentially improving heart function and overall cardiovascular wellness.

Incorporating hesperidin-rich foods or supplements into your diet may provide a natural means to support mitochondrial health and enhance overall well-being.


How to Support Mitochondrial Health?

Various lifestyle choices can elevate hesperidin levels in the body, promoting overall health:

  • Dietary Choices: Consuming a diet abundant in citrus fruits is the primary strategy to boost hesperidin intake (6). Oranges, lemons, and grapefruits are excellent sources of this flavonoid. Incorporating these fruits into daily meals or snacks can significantly elevate hesperidin levels.
  • Fresh and Whole Foods: Opt for fresh and minimally processed foods to maximize hesperidin content (7). Freshly squeezed citrus juices and whole citrus fruits contain higher hesperidin levels than packaged or processed alternatives.
  • Cooking Methods: Choose cooking methods that preserve hesperidin content. Lightly steaming or stir-frying vegetables retains more hesperidin compared to boiling, which can leach out the flavonoid.
  • Supplementation: Hesperidin supplements, available as capsules or tablets, offer a concentrated source for those not getting enough through diet alone (8).
  • Physical Activity: Regular exercise can increase the bioavailability of flavonoids like hesperidin. Exercise improves blood circulation and metabolism, potentially enhancing hesperidin absorption and utilization.



Overall, hesperidin emerges as a valuable natural compound with the potential to support mitochondrial health and counteract oxidative stress-related disorders. Incorporating hesperidin supplementation or making dietary changes to increase hesperidin intake can further amplify these positive effects.

Increase endurance during sports

How to increase endurance performance during sport

How to increase endurance performance during sport

Last updated: April 5th, 2024

April 14th, 2022

Do you experience an overall lack of energy during sports activities? Then it’s time to increase your endurance performance during physical activity. In this article, we will explain what endurance is and why it is important for you. Additionally, you will discover which nutrients and supplements can support your diet, boost your energy levels, help you recover faster, and enhance your overall performance during your training.

Increase endurance during sports

Endurance performance in different sports

Endurance is the ability to sustain an activity for extended periods of time and usually relates to aerobic or anaerobic exercise [1].

Aerobic endurance applies to sports like long-distance running or swimming where athletes exercise for extended periods. In this type of exercise, the body relies on supplying nutrients and oxygen to working muscles.

On the other hand, anaerobic endurance is related to high-intensity exercises that may last minutes such as weightlifting. In these cases, a different type of endurance (strength) is necessary to achieve the maximum number of sets and reps in a workout plan.

During anaerobic exercise, many athletes also focus on activities that include resistance with the body (calisthenics) or equipment such as weight machines and barbell exercises.

The conclusion in each case is that a high volume of training puts extreme demands on the body from a physical (strength & power), mental (focus) and energy (endurance) retention standpoint.

Why is endurance performance important?

Endurance can benefit your overall wellness by improving heart health, lowering cholesterol levels and blood pressure, preventing injuries and controlling weight [2].

As it concerns your performance skills, studies have shown that endurance helps athletes develop skills like agility, speed, power, and strength [3]. More specifically, it is an efficient way to maintain energy levels before fatigue sets in.

As an example, you can consider a basketball player who wants to jump for rebounds in the final minutes of an intense game or even a marathon athlete who needs to run the last kilometres of a demanding race.

Thus, endurance can keep your circulatory system healthy and make the difference between winning or losing in different sports.

Ways to boost your endurance during sport

Boosting endurance during sports involves focusing on two primary aspects: enhancing training capacities and taking the right nutrition.

To improve training capacities, it is crucial to gradually extend exercise durations [3]. This can be achieved by progressively increasing the duration or distance covered during training sessions over weeks, months, or even years. Additionally, for anaerobic exercises, endurance performance can be enhanced by increasing the number of repetitions with lighter weights.

However, nutrition is also an essential factor that influences the endurance of athletes. More specifically, it has been proven that nutritional supplements play a vital role in enhancing athletic performance and endurance, even though there is a lack of knowledge of their use [4]. Thus, athletes need reliable information regarding supplements they can trust and use in their daily demanding lives.

In the next section, we will focus on the ingredients that a supplement should include for increasing endurance performance.

Ingredients for endurance


Even if the body can synthesize glutamine, its levels might not be sufficient for athletes. The body can become depleted of glutamine in the case of high-intensity training [5] and as a result, athletes seek to increase the dosage intake by supplementation.

L-Glutamine accelerates muscle recovery while it helps athletes to exercise harder. The increased sodium uptake reduces muscle fatigue and breakdown while maintaining muscle growth.

The recommended dosage for L-Glutamine is between 3 to 6 grams.


As mentioned previously, athletes need endurance for different types of training. For example, marathon runners exercise for extended periods of time and require a lot of carbohydrates to sustain their performance.

Any athlete who exercises for more than 60 to 90 minutes requires carbohydrate intake during their performance to sustain sufficient energy levels for fueling muscles since their glycogen stores may only last a limited time.

A combination of carbohydrates with a small amount of protein has been shown to prevent muscle damage during endurance exercise efficiently [6].

The daily recommended dosage for carbohydrates depends on the type of exercise. Overall, the following is advised:

  • Moderate endurance exercise (1 hour per day): 5-7 g/kg of body weight daily.
  • Moderate to high-intensity endurance exercise (1-3 hours per day): 6-10 g/kg of body weight daily.
  • Moderate to high-intensity endurance exercise (4-5 hours per day). 10-12 g/kg of body weight daily.


Caffeine is a stimulant that athletes can use to boost their energy temporarily [7]. More specifically, it can increase heart rates when athletes feel fatigued and has been proven to improve endurance performance [6].

Even if caffeine improves athletes’ perception of effort, it is important to be aware of the side effects it might have in higher intakes [8]. Some of the side effects of too much caffeine are anxiety, insomnia, muscle breakdown, rapid heart rate and high blood pressure.

It is also possible that caffeine has the opposite result where consuming many caffeinated beverages is followed by fatigue [9].

The recommended clinical dose of caffeine is between 3 and 6 mg/kg.

Citrus flavonoids (hesperidin) – Power and endurance in one ingredient

To increase your endurance, strength, and power during highly intense training, you should consider citrus flavonoids (hesperidin). BioActor has developed a proprietary ingredient that is optimized for bioavailability and performance, backed up by two clinical studies: WATTS’UP®.

WATTS’UP® was studied for its beneficial effects on endurance performance and high-intensity performance at a daily dose of 400-500 mg.

The first clinical trial was conducted at the Dutch Olympic training facility. It confirmed that WATTS’UP® is capable of significantly improving aerobic power in endurance athletes compared to placebo.

A second clinical trial was tested during the Wingate Anaerobic Test. It confirmed that WATTS’UP® can be very efficient for peak force, anaerobic power, and endurance compared to placebo.


In conclusion, proper nutrition in addition to a well-designed training plan, can enhance sport performance and reduce recovery time.

Discover YAMAMOTO’s Success Story

Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.


bonolive support women health

Everything you need to know about Bonolive® and women's health

Everything you need to know about Bonolive® and women’s health

Maastricht, 29th March, 2024

bonolive women health oleuropein

How do we define women’s health?

Woman’s health encompasses a range of physical, emotional, and mental aspects. Good health allows women to engage in daily activities with ease and vitality. It enables them to pursue their goals, whether personal or professional, without being limited by health issues. Hence, women’s quality of life is largely dependent on their health and mental status (1, 2).

A pivotal milestone in a woman’s life is the menopause, primarily characterized by hormonal fluctuations, particularly a decrease in oestrogen levels. This hormonal imbalance may have implications for women’s physical and mental health. However, with proper support and a holistic approach, the individual needs of each woman can be catered for.

How can we support women’s health (particularly during menopause)?

Women’s quality of life benefits from a holistic approach, including a comprehensive and integrated plan that addresses physical, mental, emotional, and social aspects of well-being (3). The top 3 strategies to support women’s health are listed below:

  1. Nutrition: Encouraging a balanced and nutritious diet is fundamental to women’s health. Emphasize whole foods, plenty of fruits and vegetables, lean proteins, healthy fats, and whole grains. Proper nutrition supports hormone balance, bone health, immune function, and overall vitality (4).
  2. Regular Exercise: Physical activity is essential for maintaining a healthy weight, reducing the risk of chronic diseases, improving mood, and enhancing overall well-being (5). It is advisable for women to engage in regular exercise that they enjoy, whether it’s walking, swimming, yoga, or strength training.
  3. Stress Management: Chronic stress can negatively impact women’s health. Teach stress management techniques such as mindfulness meditation, deep breathing exercises, yoga, or progressive muscle relaxation. Encouraging women to prioritize self-care activities would help them relax and unwind.

Exploring nutritional solutions for women’s health

As explained above, nutrition is a top priority to maintain and support health status. If we zoom in on women’s needs during peri- and post-menopause, we can explore in more detail what are the micronutrients that could provide a benefit during this stage of life. Typically, menopause is accompanied by acute symptoms such as bloating, night sweats, hot flashes, and long-term ones like loss of bone mineral density or imbalance in blood lipid profile.

Fortunately, there are quite a few nutritional strategies to explore in terms of lowering the risk of the above-mentioned conditions (6). For example, the sufficient intake of omega 3 and 6 fatty acids (7) is important for lipids metabolism as well as skin health. Furthermore, vitamin D (8) contributes to mineral turnover and bone health. In addition, olive polyphenols like oleuropein have great potential to support women in menopause by lowering the risk of bone loss and alleviating joint pain (9, 10).

What is oleuropein?

Oleuropein is the primary polyphenol found in olives and olive leaves (11). It contributes to the bitter taste of olives, especially the unripe ones. This compound has gained recent attention due to its potential health benefits for the human body such as anti-inflammatory and antimicrobial properties (12). Research suggests that it could support cardiovascular health by improving blood lipid levels. Oleuropein is also studied for its potential to aid bone health and skin health as it may reduce chronic inflammation. Moreover, Solabia Nutrition is the pioneer in research innovations with oleuropein and it is now under investigation for supporting women’s health, especially during and post-menopause.


How can oleuropein support women’s health?

Oleuropein may offer several potential benefits for women’s health during various stages of life, including menopause. Here’s how oleuropein can support women’s health:

  • Bone Health: During menopause, women are at an increased risk of osteoporosis due to declining estrogen levels. Oleuropein has been shown to promote bone health by stimulating osteoblast activity (cells responsible for bone formation) and inhibiting osteoclast activity (cells responsible for bone resorption) (13). By supporting bone density and strength, oleuropein may help reduce the risk of osteoporosis and fractures in postmenopausal women.
  • Cardiovascular Health: Cardiovascular risk increases after menopause, partly due to changes in hormone levels. Oleuropein has been found to have cardioprotective effects, including lowering blood pressure, reducing LDL cholesterol levels, and improving endothelial function (the function of blood vessel lining) (14). These benefits may help support heart health in women, particularly postmenopausal women.
  • Anti-inflammatory Effects: Menopause is associated with increased inflammation in the body, which may contribute to various health issues such as joint pain, cardiovascular complications, and cognitive decline. Oleuropein has potent anti-inflammatory properties that can help reduce inflammation and oxidative stress, potentially alleviating symptoms and reducing the risk of chronic diseases associated with inflammation.
  • Immune Support: The immune system can undergo changes during menopause, potentially leading to increased susceptibility to infections and immune-related conditions. Oleuropein exhibits antimicrobial properties and may help support immune function by inhibiting the growth of bacteria, viruses, and fungi (14). By bolstering the immune system, oleuropein may contribute to maintaining women’s health and resilience to infections.
  • Hormonal Balance: Although more research is needed, some studies suggest that oleuropein may potentially help alleviate menopausal symptoms such as hot flashes, mood swings, and skin dryness by modulating hormone levels.
  • Skin Health: oleuropein holds promise in lowering skin inflammation and supporting skin hydration due to its moisturising and antimicrobial properties (14, 15). vigorous research is currently ongoing in this area, as technological advancements allow for accurate monitoring of improvements in skin health parameters.

Is oleuropein scientifically proven to support women?

There are numerous clinical studies assessing the effects of oleuropein. However, BioActor is the first and only to design clinical studies in the context of women’s health. Three publications in international peer-reviewed journals are testimony of BioActor’s trailblazing research for women’s health. So far, oleuropein emerged as a promising ingredient to support women peri- and post-menopause.

  1. Firstly, a 12-month oleuropein intake resulted in a significant increase in osteocalcin, a marker for bone formation (12). The intervention group also maintained bone mineral density. Additional outcomes were the significant reduction in LDL-cholesterol and total triglycerides in the intervention group, compared to placebo.
  2. Secondly, pain during walking was significantly decreased after 6 months intervention compared to baseline (16). Importantly, oleuropein intake was well tolerated, therefore it may be considered for long-term intake to relieve joint discomfort and improve mobility.
  3. Moreover, postmenopausal women exhibited elevated blood plasma concentrations of Bonolive® metabolites. These findings suggest that the bioavailability of Bonolive® is particularly high in post-menopausal women compared to pre-menopausal women (17). Moreover, MDA a marker for antioxidant status significantly improved in post-menopausal women.

Overall, oleuropein has already shown excellent potential in supporting women’s health and menopause concerns. Therefore, our research group continues to investigate the effects of this ingredient on factors related to women’s health and menopause.


What is Bonolive®?

Bonolive® is Solabia Nutrition’s patented olive leaf extract standardized for high levels of oleuropein. This all-natural ingredient is clinically validated in post-menopausal women to support women’s health during post-menopause, notably by:

  • Enhancing the number and activity of bone-producing cells (osteoblasts)
  • Stabilizing bone mineral density (18)
  • Improving blood lipids/lowering bad cholesterol
  • Improving mobility/reducing joint pain
  • Alleviating menopause symptoms related to mood and skin appearance (19, 20).


The history of Bonolive®

It all started with the breakthrough research of Professor Veronique Coxam on the bone protective properties of oleuropein at the French research institute INRA. Her colleague Marie-Noelle Horcajada continued working on the joint health benefits of Bonolive® at Nestlé Health Science. In parallel, BioActor’s CSO, Dr Yala Stevens and principal scientist Maria Imperatrice have been spearheading the research on Bonolive’s bioavailability and peri-menopause-related effects. More than 150 women took part in our studies as volunteers.


How are the olive leaves sourced?

Olive leaves provide the oleuropein present in Bonolive®. The olive plantation that provides the leaves for Bonolive® is situated near Cordoba, Spain. During the pruning season, the fresh leaves are collected and stored in a special environment to preserve the oleuropein content for extraction. This is an upcycling process, with the olive leaves being a clean and environmentally friendly source of oleuropein for Bonolive®.

Who can benefit from taking Bonolive®?

Bonolive® is a high-quality, 100% clean and scientifically backed ingredient, designed for women by women. Bonolive® targets specifically women in peri- and post-menopause, who need tailored support throughout this important life stage (21). Our latest consumer study suggests that women experiencing acute symptoms such as hot flashes, mood swings, and night sweats may notice improvements after just two weeks of use (22).

Easy formulation options with Bonolive®

Bonolive® is a great addition to any product formulation targeting women’s health, specifically menopause concerns. It has a convenient clinically validated dose of 250 mg which fits quite well in capsules. This ingredient is also lipids- and water soluble and can be formulated into softgels, effervescent tablets or beverages. It is also suitable for direct compression in the form of tablets.

Current products on the market often combine Bonolive® with other minerals, vitamins and botanicals suitable to support women’s health such as calcium, magnesium, iron, vitamins B, C & D etc. Our team can also offer formulation advice and guidance according to your specific projects.


Bonolive® is a safe solution for menopause support

Moreover, Bonolive® is well tolerated and suitable for long-term consumption to support menopausal women. Bonolive does not contain oestrogens, as opposed to isoflavones. BioActor commissioned extensive safety studies with Bonolive that have been published in a peer-reviewed journal. Recently, the US FDA approved the GRAS status of Bonolive for inclusion in functional foods and beverages, further affirming its high quality and safety standards.


Nutritional strategies to relieve menopause symptoms

Nutritional strategies to relieve menopause symptoms

Last updated: March 22nd, 2024

March 16th, 2023

During and after menopause, many women experience uncomfortable symptoms such as bloating, hot flashes, and night sweats. While hormonal therapy can help alleviate symptoms, it may also have side effects. Therefore, more attention is being given to changes in diet or the use of natural supplements. This article will explore nutritional strategies that may provide relief from menopause symptoms.


Foods to alleviate menopause symptoms

As women approach menopause, a lot of changes occur. Their estrogen levels decrease, leading to various symptoms such as bloating, night sweats, anxiety, or depression.

Menopause can also increase the risk of cardiovascular diseases and bone loss, which are commonly ignored. However, making some dietary changes can be an effective and easy way to alleviate these symptoms. In this article, we will discuss five foods that can help ease menopause symptoms.

1. Fish rich in n-3 PUFAs for menopause support

Fish is a great source of healthy and essential fatty acids, including omega-3 polyunsaturated fatty acids (n-3 PUFAs) that have protective effects and anti-inflammatory actions. These fatty acids are found in fatty fish like salmon and some algae species.

Research has shown that consuming fish or fish oil can reduce depression, anxiety (1), hot flashes, and sleeping problems (2) in menopausal women. In addition, fatty fish is rich in vitamin D, which is essential for calcium absorption and maintaining bone health.

If you don’t eat fish, you can still get the benefits of n-3 PUFAs by consuming foods rich in α-linoleic acid (ALA), which our bodies can convert into these beneficial fatty acids. ALA has been shown to improve skin hydration and smoothness and can be found in foods like flaxseeds, almonds, walnuts, and chia seeds (1), as well as soy products that we’ll discuss later.

2. Olive leaf extract for menopausal symptoms

Olives contain (poly)phenolic compounds that have many positive effects, including antioxidant, anti-inflammatory, and anticancer properties (3).

Interestingly, olive leaves contain significantly higher concentrations of phenolic compounds than olives or olive oil (4). As a result, they may have even greater potential for exerting beneficial effects on health. In fact, research has already demonstrated that taking olive leaf extract daily can be an effective alternative treatment for reducing blood pressure in individuals with hypertension (5).

One of the key phenolic compounds found in olive leaf extract is oleuropein, which has been shown to significantly impact women’s health during post-menopause. Oleuropein has been proven to reduce cholesterol levels, lower the risk of bone loss, alleviate joint pain, improve skin health and enhance mobility (6,7).

Bonolive® is an olive leaf product that is standardized for high levels of oleuropein.

3. Soy products

Soy products, including soy milk, soybeans, and tofu, are rich in isoflavones, which are plant-derived estrogens and selective modulators of estrogen receptors in the body. These properties make soy products a promising alternative to hormonal therapy.

Soybeans contain essential fatty acids, such as ALA (α-linoleic acid), that have anti-inflammatory properties. Additionally, soy protein has been found to reduce bad cholesterol levels, which can lower the risk of cardiovascular diseases (8).

One of the isoflavones found in soybeans is genistein, which is structurally similar to female estrogen and can alleviate menopausal hot flashes. Another isoflavone, daidzein, can inhibit cell proliferation in the gastrointestinal tract, potentially reducing the risk of estrogen-sensitive cancers, such as ovary, prostate, and breast cancer (9).

4. Yogurt to support menopause

Yogurt is a nutrient-rich food that contains calcium and vitamin D, which are important ingredients to improve bone health during menopause. Bifidobacterium bifidum and Lactobacillus acidophilus, which are considered ‘good’ bacteria, are used to make yoghurt and they are also present in the final product, making yogurt a source of probiotics that can benefit gut health.

Research has shown that consuming extra probiotics in yogurt can help to reduce anxiety and stress levels, and improve overall quality of life compared to regular yogurt (10). However, regular yogurt also has similar long-term effects. Additionally, yogurt may have a role in appetite control, making it a helpful food for weight management (11).

Studies have suggested that a well-balanced diet that includes milk and dairy products, like yogurt, may also improve sleep quality (12).

How can foods help with menopause symptoms?

To summarize, consuming fish, soy products, whole grains, olive leaf extract, and yogurt can promote healthy cholesterol levels, maintain bone mass, reduce menopausal symptoms such as hot flashes and mood swings, and help regulate appetite and blood sugar levels. If you’re experiencing menopausal symptoms, these natural products are worth considering.

naxus in gut health formula

4 reasons to include Naxus® in your gut health formulation

4 reasons to include Naxus® in your gut health formulation

Maastricht, 15th March, 2024

Arabinoxylans are essential prebiotics that exert beneficial effects on human health, particularly gut health. The relationship between diet and gut health has gained popularity in the last decades, with promising research emerging at an increasingly rapid pace. For product developers, it can be challenging to decide which ingredients to include in their gut formulation. In this article, you will discover 4 compelling reasons to include Naxus® in your gut health formulation.

What is Naxus®?

Naxus® is a patent-protected, prebiotic arabinoxylan extract sourced from the wheat endosperm. It can boost the immune system and improve gut health.

Solabia-BioActor developed Naxus® and conducted extensive research in collaboration with Maastricht University, Wageningen University & Research, Institute Pasteur and more, demonstrating its positive effects in numerous studies.

Clinical research in diverse populations shows that Naxus® promotes gut health by improving intestinal barrier function, increasing beneficial micro-organisms (e.g., Bifidobacteria and Bacteroides), improving the short-chain fatty acid (SCFA) profile and inducing cytokine and chemokine production (1, 2, 3).

Naxus® exerts its beneficial effects at doses starting at 1 g. Click below to see the scientific evidence.

4 reasons why Naxus® is a great addition to gut health formulations

If you are considering including Naxus® in your formulation for gut health, you should consider the following aspects:


1. Naxus® improves SCFA profile and strengthens the gut barrier

Health-promoting micro-organisms are present in the gut and help to protect the gut wall from pathogens and bad bacteria. Studies have demonstrated that Naxus® supports the growth of beneficial microbiota (1). Consequently, these microbiota produce advantageous SCFAs like propionate and butyrate.

SCFA production is related to a variety of positive health effects. To illustrate, these metabolites reduce the risk of developing inflammation and promote psychological and physical health. Moreover, they regulate the host immune system and improve metabolic health (4, 5).


2. Naxus® supports the immune system 

Naxus® has proven immunomodulatory properties by enhancing gut barrier integrity and improving the adaptive and innate immune system.

Research indicates that Naxus® improves multiple gut barrier parameters such as reduced intestinal permeability, increased goblet cell number, and higher intestinal immunoglobin A concentrations (6).

Additionally, Naxus® has been shown to increase vaccination efficacy against influence resulting in fewer adverse events, fewer respiratory tract infections, and improved seroprotection rates (7).

Moreover, Naxus® improves the innate immune system, leading to an increased immune system vigilance (2, 3).


3. Naxus® is slowly fermentable without bloating

Naxus® is composed of long and complex carbohydrate molecules, that ferment slowly and gradually (8). Therefore, Naxus® has an advantage over other fibres like inulin, because it does not cause intestinal complaints such as bloating and gas formation in the gut.


4. Naxus® can be used in many formulation types

Arabinoxylans, with their favourable physicochemical properties, have been successfully incorporated into numerous food products. Naxus® is wheat-derived and gluten-free and is therefore suitable for various formulations.

Naxus® has an emulsifying capacity and influences the viscosity of multiple foods. Its effects have been tested in products such as pasta, bread, beer, cakes, and cookies. For example, in the bread-making processes, arabinoxylans positively affect dough consistency, loaf volumes, crumb structure, and bread staling.

These beneficial technological characteristics prove the potential to include Naxus® in any gut health formulation.


Naxus®, the key ingredient for your gut health formulation

Naxus® contributes to your gut health by improving the microbiome, protecting the intestinal gut barrier, and supporting the immune system. It is a patent-protected product that bears an EFSA claim for reduction of post-prandial glycemic response and can be incorporated into multiple food products due to its beneficial properties.

Its innovative and science-based nature makes it a valuable addition to optimise your gut health formulation!